scholarly journals Cultivated Fruit Body of Phellinus baumii: A Potentially Sustainable Antidiabetic Resource

ACS Omega ◽  
2020 ◽  
Vol 5 (15) ◽  
pp. 8596-8604
Author(s):  
Kai Yang ◽  
Su Zhang ◽  
Youmin Ying ◽  
Yougui Li ◽  
Ming Cai ◽  
...  
Keyword(s):  
Fruit Body ◽  
Phellinus Baumii

scholarly journals Anti-Inflammatory Properties In Vitro and Hypoglycaemic Effects of Phenolics from Cultivated Fruit Body of Phellinus baumii in Type 2 Diabetic Mice

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2285
Author(s):  
Kai Yang ◽  
Su Zhang ◽  
Yan Geng ◽  
Baoming Tian ◽  
Ming Cai ◽  
...  
Keyword(s):  
Dietary Intervention ◽  
Fruit Body ◽  
Raw 264.7 Cells ◽  
Control Group ◽  
Inflammatory Factor ◽  
Dependent Manner ◽  
Diabetic Mice ◽  
Phellinus Baumii ◽  
Anti Inflammatory

Dietary intervention in type 2 diabetes mellitus (T2DM) is a hotspot in international research because of potential threats to human health. Phellinus baumii, a wild fungus traditionally used as a food and medicine source, is now cultivated in certain East Asian countries, and is rich in polyphenols, which are effective anti-inflammatory ingredients useful in treatment of T2DM, with fewer side effects than drugs. To examine the hypoglycaemic effects of Phellinus baumii phenolics (PPE), the metabolite profiles of T2DM mice induced by streptozotocin after PPE intervention were systematically analyzed. Here, 10 normal mice were given normal saline as control group, and 50 model mice were randomly assigned to five groups and daily intragastric administrated with saline, metformin (100 mg/kg), and PPE (50, 100, 150 mg/kg of body weight), for 60 days. The pro-inflammatory factor contents of lipopolysaccharide stimulation of RAW 264.7 cells were decreased in a dose-dependent manner after PPE treatment, we propose that PPE could exert anti-inflammatory properties. PPE could also effectively reduce blood glucose levels, increased insulin sensitivity, and improved other glucolipid metabolism. Q-PCR results suggested that the hypoglycemic effects of PPE might be through activating IRS1/PI3K/AKT pathway in diabetic mice. These results suggest that PPE has strong potential as dietary components in the prevention or management of T2DM.

scholarly journals Proteinases from the Fruit-body of Flammulina velutipes.

1995 ◽  
Vol 42 (11) ◽  
pp. 907-912 ◽  
Author(s):  
Takao TERASHITA ◽  
Makoto NAWAMA ◽  
Kentaro YOSHIKAWA ◽  
Jiko SHISHIYAMA
Keyword(s):  
Fruit Body ◽  
Flammulina Velutipes

scholarly journals Network Biology Approach to Identify the Active Ingredients, Potential Targets, and Signaling Pathways in Phellinus Baumii and Salvia Miltiorrhiza Bunge on Vascular Health (P15-025-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yeni Lim ◽  
Oran Kwon
Keyword(s):  
Clinical Trial ◽  
Signaling Pathways ◽  
Platelet Activation ◽  
Vascular Dysfunction ◽  
Salvia Miltiorrhiza ◽  
Network Biology ◽  
Vascular Health ◽  
Salvia Miltiorrhiza Bunge ◽  
Phellinus Baumii ◽  
Target Molecules

Abstract Objectives Increasing attention has been paid to a range of botanical food supplement that help to maintain vascular health. Multiple components in botanical foods are expected to be working in concert with various targets. In a previous our animal study, Phellinus baumii and Salvia miltiorrhiza Bunge (PS) ameliorated endothelial and vascular dysfunction in a platelet activation rat model. This study aimed to provide the components, target molecules, phenotypes, signaling pathways, and investigate the mechanism of PS on vascular health. Methods Network biology analysis was based on the data from two clinical trials. The first clinical trial was performed in healthy subjects using high-fat-induced vascular dysfunction model. The second clinical trial was performed in healthy smokers. Differential markers obtained from clinical data, Affymetrix microarray, metabolomics, together with ingredient of PS, were mapped onto the network platform termed the context-oriented directed associations. A network of “component-target-phenotype-pathway” was constructed. Results The resulting vascular health network demonstrates that the components of PS are linked various target molecules for adhesion molecule production, platelet activation, endothelial inflammation, vascular dilation, and mitochondrial metabolism and detoxification, implicated with various metabolic pathways. Conclusions Using network biology methods, this study revealed the components and their target molecules, phenotypes, signaling pathways and provided wider information to support the synergistic mechanisms of PS on vascular health. Funding Sources This research was funded by the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science & ICT and the BK21PLUS of the National Research Foundation.

Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii

2021 ◽  
pp. 118214
Author(s):  
Yuqing Sun ◽  
Jinxi Huo ◽  
Shi Zhong ◽  
Jianxun Zhu ◽  
Yougui Li ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Inflammatory Activity ◽  
Phellinus Baumii ◽  
Anti Inflammatory

Light-induced fruit body formation of an entomogenous fungus Paecilomyces tenuipes

Mycoscience ◽  
1999 ◽  
Vol 40 (4) ◽  
pp. 349-351 ◽  
Author(s):  
Akihito Kana-uchi ◽  
Takema Fukatsu
Keyword(s):  
Fruit Body ◽  
Entomogenous Fungus ◽  
Body Formation ◽  
Fruit Body Formation

scholarly journals Separation and characterization of alkaline nuclease in the fruit body of Flammulina velutipes.

1985 ◽  
Vol 49 (7) ◽  
pp. 2181-2183 ◽  
Author(s):  
Shin''ichi KUROSAWA ◽  
Kazuharu KATOH ◽  
Hideki YOKOMICHI
Keyword(s):  
Fruit Body ◽  
Flammulina Velutipes ◽  
Alkaline Nuclease
Sign in / Sign up

Export Citation Format

Share Document