scholarly journals The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling

2020 ◽  
Vol 3 (4) ◽  
pp. 676-689
Author(s):  
Hyouk-Bum Kwon ◽  
Duncan I. Mackie ◽  
Remy Bonnavion ◽  
Alan Le Mercier ◽  
Christian S. M. Helker ◽  
...  
Keyword(s):  
G Protein ◽  
Leukotriene B4 ◽  
Negative Regulator ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Definitive Hematopoiesis

scholarly journals Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

2016 ◽  
Vol 212 (7) ◽  
pp. 861-875 ◽  
Author(s):  
Kasturi Pal ◽  
Sun-hee Hwang ◽  
Bandarigoda Somatilaka ◽  
Hemant Badgandi ◽  
Peter K. Jackson ◽  
...  
Keyword(s):  
Membrane Protein ◽  
G Protein ◽  
Primary Cilium ◽  
Protein Composition ◽  
Negative Regulator ◽  
G Protein Coupled Receptor ◽  
New Paradigm ◽  
Subcellular Compartment ◽  
Shh Pathway ◽  
G Protein Coupled

Dynamic changes in membrane protein composition of the primary cilium are central to development and homeostasis, but we know little about mechanisms regulating membrane protein flux. Stimulation of the sonic hedgehog (Shh) pathway in vertebrates results in accumulation and activation of the effector Smoothened within cilia and concomitant disappearance of a negative regulator, the orphan G protein–coupled receptor (GPCR), Gpr161. Here, we describe a two-step process determining removal of Gpr161 from cilia. The first step involves β-arrestin recruitment by the signaling competent receptor, which is facilitated by the GPCR kinase Grk2. An essential factor here is the ciliary trafficking and activation of Smoothened, which by increasing Gpr161–β-arrestin binding promotes Gpr161 removal, both during resting conditions and upon Shh pathway activation. The second step involves clathrin-mediated endocytosis, which functions outside of the ciliary compartment in coordinating Gpr161 removal. Mechanisms determining dynamic compartmentalization of Gpr161 in cilia define a new paradigm for down-regulation of GPCRs during developmental signaling from a specialized subcellular compartment.

scholarly journals Increased Acute Inflammation, Leukotriene B4-Induced Chemotaxis, and Signaling in Mice Deficient for G Protein-Coupled Receptor Kinase 6

2003 ◽  
Vol 171 (11) ◽  
pp. 6128-6134 ◽  
Author(s):  
Annemieke Kavelaars ◽  
Anne Vroon ◽  
Roel P. Raatgever ◽  
Alan M. Fong ◽  
Richard T. Premont ◽  
...  
Keyword(s):  
G Protein ◽  
Acute Inflammation ◽  
Leukotriene B4 ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Role of Translocator 18 KDa Ligands in the Activation of Leukotriene B4 Activated G-Protein Coupled Receptor and Toll Like Receptor-4 Pathways in Neutrophils

2017 ◽  
Vol 8 ◽  
Author(s):  
Léonard de Vinci Kanda Kupa ◽  
Carine C. Drewes ◽  
Eric D. Barioni ◽  
Camila L. Neves ◽  
Sandra Coccuzzo Sampaio ◽  
...  
Keyword(s):  
G Protein ◽  
Leukotriene B4 ◽  
Toll Like Receptor ◽  
G Protein Coupled Receptor ◽  
Toll Like Receptor 4 ◽  
G Protein Coupled

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

Nature ◽  
10.1038/42506 ◽  
1997 ◽  
Vol 387 (6633) ◽  
pp. 620-624 ◽  
Author(s):  
Takehiko Yokomizo ◽  
Takashi Izumi ◽  
Kyungho Chang ◽  
Yoh Takuwa ◽  
Takao Shimizu
Keyword(s):  
G Protein ◽  
Leukotriene B4 ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
Sign in / Sign up

Export Citation Format

Share Document