Impact of Shape and Pore Size of Mesoporous Silica Nanoparticles on Serum Protein Adsorption and RBCs Hemolysis

2014 ◽  
Vol 6 (4) ◽  
pp. 2431-2438 ◽  
Author(s):  
Zhifang Ma ◽  
Jing Bai ◽  
Yichen Wang ◽  
Xiue Jiang
Keyword(s):  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Serum Protein ◽  
Mesoporous Silica Nanoparticles

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

Blood clot initiation by mesoporous silica nanoparticles: dependence on pore size or particle size?

2016 ◽  
Vol 4 (44) ◽  
pp. 7146-7154 ◽  
Author(s):  
Zihao Chen ◽  
Fan Li ◽  
Changjun Liu ◽  
Jing Guan ◽  
Xiao Hu ◽  
...  
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Blood Clot

The hemostatic efficiency of mesoporous silica nanoparticles depends on pore size more than particle size, and biocompatibility is more related to particle size.

scholarly journals Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24633-24640 ◽  
Author(s):  
Jie Li ◽  
Suqin Shen ◽  
Fei Kong ◽  
Ting Jiang ◽  
Cui Tang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Pore Sizes

MSN with suitable pore sizes achieved an outstanding performance for in vitro and in vivo antitumor efficacies.

scholarly journals Luminescent Mesoporous Silica Nanohybrid Based on Drug Derivative Terbium Complex

Materials ◽  
2019 ◽  
Vol 12 (6) ◽  
pp. 933 ◽  
Author(s):  
Fernando Maturi ◽  
Rafael Sábio ◽  
Robson Silva ◽  
Marcelo Lahoud ◽  
Andréia Meneguin ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
The Novel ◽  
High Cell ◽  
Terbium Complex ◽  
Two Photon ◽  
Photon Excitation ◽  
Mesoporous Nanoparticles

Mesoporous silica nanoparticles prepared by organic template-driven synthesis have been successfully explored as carriers of the drug-derivate green luminescent complex of terbium (III) with the nonsteroidal anti-inflammatory drug ketoprofen. The terbium (III) complex was synthesized by reacting ketoprofen sodium salt with terbium (III) chloride, which was further adsorbed onto the surface of mesoporous nanoparticles with a mean particle size of 47 ± 4 nm and pore size of 11 nm. The incorporation of the complex into mesoporous silica nanoparticles was tracked by the decrease in the surface area and pore size of the nanoparticles, and successfully demonstrated by substantial changes in the adsorption isotherms and thermal and vibrational spectroscopy results. The cytotoxicity assay and confocal microscopy have shown that the novel luminescent nanohybrid presents high cell viability and the characteristic terbium (III) emission can be assessed through two-photon excitation, which paves the way for bioimaging applications in nanomedicine.

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