Serum Protein Adsorption Enhances Active Leukemia Stem Cell Targeting of Mesoporous Silica Nanoparticles

2017 ◽  
Vol 9 (22) ◽  
pp. 18566-18574 ◽  
Author(s):  
Michaela Beck ◽  
Tamoghna Mandal ◽  
Christian Buske ◽  
Mika Lindén
Keyword(s):  
Stem Cell ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Serum Protein ◽  
Mesoporous Silica Nanoparticles ◽  
Cell Targeting ◽  
Leukemia Stem Cell

scholarly journals Platelet lysates-based hydrogels incorporating bioactive mesoporous silica nanoparticles for stem cell osteogenic differentiation

2021 ◽  
Vol 9 ◽  
pp. 100096
Author(s):  
M.T. Tavares ◽  
S.C. Santos ◽  
C.A. Custódio ◽  
J.P.S. Farinha ◽  
C. Baleizão ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesoporous Silica ◽  
Osteogenic Differentiation ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

Mesoporous Silica Nanoparticles-Reinforced Hydrogel Scaffold together with Pinacidil Loading to Improve Stem Cell Adhesion

ChemNanoMat ◽  
2018 ◽  
Vol 4 (7) ◽  
pp. 631-641 ◽  
Author(s):  
Ning Wang ◽  
Ming Ma ◽  
Yu Luo ◽  
Tianzhi Liu ◽  
Peng Zhou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Adhesion ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrogel Scaffold

scholarly journals Mesoporous Silica Nanoparticles as a Delivery System of Gadolinium for Effective Human Stem Cell Tracking

Small ◽  
2008 ◽  
Vol 4 (9) ◽  
pp. 1445-1452 ◽  
Author(s):  
Jong-Kai Hsiao ◽  
Chih-Pin Tsai ◽  
Tsai-Hua Chung ◽  
Yann Hung ◽  
Ming Yao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Cell Tracking ◽  
Mesoporous Silica Nanoparticles ◽  
Human Stem Cell ◽  
Stem Cell Tracking

scholarly journals An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yang Yang ◽  
Weihua Zhao ◽  
Wenwen Tan ◽  
Zongqiang Lai ◽  
Dong Fang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Mesoporous Silica Nanoparticles ◽  
Difficult Problem ◽  
Leukemia Cells ◽  
Cell Targeting

AbstractHow to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery system (Sgc8-MSN/Dox) based on aptamer-modified mesoporous silica nanoparticles that relies on the tumor-targeting ability of the aptamer Sgc8 to deliver doxorubicin (Dox) to leukemia cells in a targeted way, thereby improving therapeutic efficacy and reducing toxicity. In this work, Sgc8-MSN/Dox showed sustained Dox release, and they targeted and efficiently killed CCRF-CEM human acute T lymphocyte leukemia cells, suggesting potential as a cancer therapy.

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