scholarly journals Janus Particles as Artificial Antigen-Presenting Cells for T Cell Activation

2014 ◽  
Vol 6 (21) ◽  
pp. 18435-18439 ◽  
Author(s):  
Bo Chen ◽  
Yilong Jia ◽  
Yuan Gao ◽  
Lucero Sanchez ◽  
Stephen M. Anthony ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Antigen Presenting Cells ◽  
Janus Particles ◽  
Artificial Antigen ◽  
Antigen Presenting

scholarly journals Immunoengineering: Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation (Small 13/2015)

Small ◽  
2015 ◽  
Vol 11 (13) ◽  
pp. 1612-1612 ◽  
Author(s):  
Randall A. Meyer ◽  
Joel C. Sunshine ◽  
Karlo Perica ◽  
Alyssa K. Kosmides ◽  
Kent Aje ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Antigen Presenting Cells ◽  
Artificial Antigen ◽  
Antigen Presenting

scholarly journals Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

Biomaterials ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 269-277 ◽  
Author(s):  
Joel C. Sunshine ◽  
Karlo Perica ◽  
Jonathan P. Schneck ◽  
Jordan J. Green
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Particle Shape ◽  
Cell Activation ◽  
Antigen Presenting Cells ◽  
Cd8 T Cell ◽  
Shape Dependence ◽  
Artificial Antigen ◽  
Antigen Presenting

scholarly journals Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

Small ◽  
2015 ◽  
Vol 11 (13) ◽  
pp. 1519-1525 ◽  
Author(s):  
Randall A. Meyer ◽  
Joel C. Sunshine ◽  
Karlo Perica ◽  
Alyssa K. Kosmides ◽  
Kent Aje ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Antigen Presenting Cells ◽  
Artificial Antigen ◽  
Antigen Presenting

scholarly journals Abortive Proliferation of Rare T Cells Induced by Direct or Indirect Antigen Presentation by Rare B Cells In Vivo

1998 ◽  
Vol 187 (10) ◽  
pp. 1611-1621 ◽  
Author(s):  
Sarah E. Townsend ◽  
Christopher C. Goodnow
Keyword(s):  
T Cells ◽  
T Cell ◽  
B Cells ◽  
Antigen Presentation ◽  
Cell Fate ◽  
T Cell Activation ◽  
Cell Activation ◽  
Antigen Presenting Cells ◽  
Antigen Presenting

Antigen-specific B cells are implicated as antigen-presenting cells in memory and tolerance responses because they capture antigens efficiently and localize to T cell zones after antigen capture. It has not been possible, however, to visualize the effect of specific B cells on specific CD4+ helper T cells under physiological conditions. We demonstrate here that rare T cells are activated in vivo by minute quantities of antigen captured by antigen-specific B cells. Antigen-activated B cells are helped under these conditions, whereas antigen-tolerant B cells are killed. The T cells proliferate and then disappear regardless of whether the B cells are activated or tolerant. We show genetically that T cell activation, proliferation, and disappearance can be mediated either by transfer of antigen from antigen-specific B cells to endogenous antigen-presenting cells or by direct B–T cell interactions. These results identify a novel antigen presentation route, and demonstrate that B cell presentation of antigen has profound effects on T cell fate that could not be predicted from in vitro studies.

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