Synthesis and Characterization of Oligomeric nido-Carboranyl Phosphate Diester Conjugates to Antibody and Antibody Fragments for Potential Use in Boron Neutron Capture Therapy of Solid Tumors

1994 ◽  
Vol 5 (6) ◽  
pp. 557-564 ◽  
Author(s):  
Charng-Jui Chen ◽  
Robert R. Kane ◽  
F. James Primus ◽  
Gyorgy Szalai ◽  
M. Frederick Hawthorne ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antibody Fragments ◽  
Synthesis And Characterization ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Phosphate Diester ◽  
Potential Use

scholarly journals Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3288 ◽  
Author(s):  
Martin Kellert ◽  
Peter Lönnecke ◽  
Bernd Riedl ◽  
Johannes Koebberling ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Carboxylic Acid ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Acid Ester ◽  
Tumor Tissue ◽  
Modular System ◽  
Synthesis And Characterization ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.

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