scholarly journals Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3288 ◽  
Author(s):  
Martin Kellert ◽  
Peter Lönnecke ◽  
Bernd Riedl ◽  
Johannes Koebberling ◽  
Evamarie Hey-Hawkins

The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.

2020 ◽  
Vol 49 (1) ◽  
pp. 57-69 ◽  
Author(s):  
Martin Kellert ◽  
Paul Hoppenz ◽  
Peter Lönnecke ◽  
Dennis J. Worm ◽  
Bernd Riedl ◽  
...  

Introduction of a galactopyranosyl moiety in s-triazine-based boron-rich carboxylic acids and amines results in soluble and suitable coupling partners for tumour-selective biomolecules with applications in boron neutron capture therapy (BNCT).


2019 ◽  
Vol 48 (29) ◽  
pp. 10834-10844 ◽  
Author(s):  
Martin Kellert ◽  
Dennis J. Worm ◽  
Paul Hoppenz ◽  
Menyhárt B. Sárosi ◽  
Peter Lönnecke ◽  
...  

Boron-rich carboxylic acid derivatives were synthesised as coupling partners for tumour-selective biomolecules with applications as selective BNCT agents.


2010 ◽  
Author(s):  
Alejandro A. Burlon ◽  
Santiago Girola ◽  
Alejandro A. Valda ◽  
Daniel M. Minsky ◽  
Andrés J. Kreiner ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document