Synthesis and Characterization of Carborane Functionalized Dendronized Polymers as Potential Boron Neutron Capture Therapy Agents

2008 ◽  
pp. 238-249 ◽  
Author(s):  
S. Rahima Benhabbour ◽  
Alex Adronov
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Synthesis And Characterization ◽  
Neutron Capture Therapy ◽  
Dendronized Polymers ◽  
Boron Neutron Capture

scholarly journals Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3288 ◽  
Author(s):  
Martin Kellert ◽  
Peter Lönnecke ◽  
Bernd Riedl ◽  
Johannes Koebberling ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Carboxylic Acid ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Acid Ester ◽  
Tumor Tissue ◽  
Modular System ◽  
Synthesis And Characterization ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.

Experimental and Simulated Characterization of a Beam Shaping Assembly for Accelerator- Based Boron Neutron Capture Therapy (AB-BNCT)

2010 ◽  
Author(s):  
Alejandro A. Burlon ◽  
Santiago Girola ◽  
Alejandro A. Valda ◽  
Daniel M. Minsky ◽  
Andrés J. Kreiner ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Beam Shaping ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Beam Shaping Assembly

scholarly journals Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

2008 ◽  
Vol 6 (2) ◽  
pp. 154-160
Author(s):  
Afaf Genady ◽  
Mohamed El-Zaria ◽  
Detlef Gabel
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Imidazole Ring ◽  
Pyrimidine Ring ◽  
Neutron Capture Therapy ◽  
Reaction Conditions ◽  
Ligand Exchange Reaction ◽  
Boron Neutron Capture ◽  
Derivatives Of

AbstractDerivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions.

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