scholarly journals Systematic Evaluation of Candidate Ligands Regulating Ectodomain Shedding of Amyloid Precursor Protein

Biochemistry ◽  
2013 ◽  
Vol 52 (19) ◽  
pp. 3264-3277 ◽  
Author(s):  
Heather C. Rice ◽  
Tracy L. Young-Pearse ◽  
Dennis J. Selkoe
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Systematic Evaluation ◽  
Ectodomain Shedding

scholarly journals P1-088: Systematic evaluation of candidate ligands regulating ectodomain shedding of the amyloid precursor protein

2013 ◽  
Vol 9 ◽  
pp. P183-P183
Author(s):  
Heather Rice ◽  
Tracy Young-Pearse ◽  
Dennis Selkoe
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Systematic Evaluation ◽  
Ectodomain Shedding

scholarly journals Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein

2008 ◽  
Vol 6 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
Stefanie Leuchtenberger ◽  
Juan Maler ◽  
Eva Czirr ◽  
Julia Ness ◽  
Stefan F. Lichtenthaler ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Ectodomain Shedding ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

2004 ◽  
Vol 271 (12) ◽  
pp. 2539-2547 ◽  
Author(s):  
Tobias M. J. Allinson ◽  
Edward T. Parkin ◽  
Thomas P. Condon ◽  
Sylva L. U. Schwager ◽  
Edward D. Sturrock ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Ectodomain Shedding ◽  
Converting Enzyme

scholarly journals Characterization of the Ectodomain Shedding of the β-Site Amyloid Precursor Protein-cleaving Enzyme 1 (BACE1)

2003 ◽  
Vol 278 (38) ◽  
pp. 36264-36268 ◽  
Author(s):  
Ishrut Hussain ◽  
Julie Hawkins ◽  
Aarti Shikotra ◽  
David R. Riddell ◽  
Andrew Faller ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Ectodomain Shedding

scholarly journals Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4receptor and Epac

FEBS Letters ◽  
2005 ◽  
Vol 579 (5) ◽  
pp. 1136-1142 ◽  
Author(s):  
Sylvain Robert ◽  
Marjorie Maillet ◽  
Eric Morel ◽  
Jean-Marie Launay ◽  
Rodolphe Fischmeister ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Ectodomain Shedding ◽  
Protein Ectodomain Shedding ◽  
Amyloid Precursor Protein Ectodomain

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

Interplay between Pur α and Egr-1 in the transcriptional regulation of amyloid precursor protein gene expression

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Jianqi Cui ◽  
Xiuying Pei ◽  
Qian Zhang ◽  
Bassel E. Sawaya ◽  
Xiaohong Lu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Amyloid Precursor Protein ◽  
Protein Gene ◽  
Precursor Protein ◽  
Amyloid Precursor Protein Gene

Insulinrezeptorsubstrat (IRS)2-Expression moduliert die Amyloid-Precursor-Protein (APP) Spaltung in vivo

2010 ◽  
Vol 5 (S 01) ◽  
Author(s):  
M Udelhoven ◽  
T Ehlkes ◽  
MM Hettich ◽  
S Asrat ◽  
W Krone ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein
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