Ornithine Decarboxylase Antizyme Upregulates DNA-Dependent Protein Kinase and Enhances the Nonhomologous End-Joining Repair of DNA Double-Strand Breaks in Human Oral Cancer Cells†

Biochemistry ◽  
2007 ◽  
Vol 46 (31) ◽  
pp. 8920-8932 ◽  
Author(s):  
Takanori Tsuji ◽  
Miki Katsurano ◽  
Soichiro Ibaragi ◽  
Kaori Shima ◽  
Akira Sasaki ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Oral Cancer ◽  
Double Strand Breaks ◽  
Nonhomologous End Joining ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Dependent Protein Kinase ◽  
Strand Breaks ◽  
Dependent Protein ◽  
Oral Cancer Cells

scholarly journals DNA-Dependent Protein Kinase Catalytic Subunit: The Sensor for DNA Double-Strand Breaks Structurally and Functionally Related to Ataxia Telangiectasia Mutated

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1143
Author(s):  
Yoshihisa Matsumoto ◽  
Anie Day D. C. Asa ◽  
Chaity Modak ◽  
Mikio Shimada
Keyword(s):  
Protein Kinase ◽  
Ataxia Telangiectasia ◽  
Catalytic Subunit ◽  
Nonhomologous End Joining ◽  
Dna Double Strand Breaks ◽  
Ataxia Telangiectasia Mutated ◽  
End Joining ◽  
Dependent Protein Kinase ◽  
Strand Breaks ◽  
Dependent Protein

The DNA-dependent protein kinase (DNA-PK) is composed of a DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/Ku80 heterodimer. DNA-PK is thought to act as the “sensor” for DNA double-stranded breaks (DSB), which are considered the most deleterious type of DNA damage. In particular, DNA-PKcs and Ku are shown to be essential for DSB repair through nonhomologous end joining (NHEJ). The phenotypes of animals and human individuals with defective DNA-PKcs or Ku functions indicate their essential roles in these developments, especially in neuronal and immune systems. DNA-PKcs are structurally related to Ataxia–telangiectasia mutated (ATM), which is also implicated in the cellular responses to DSBs. DNA-PKcs and ATM constitute the phosphatidylinositol 3-kinase-like kinases (PIKKs) family with several other molecules. Here, we review the accumulated knowledge on the functions of DNA-PKcs, mainly based on the phenotypes of DNA-PKcs-deficient cells in animals and human individuals, and also discuss its relationship with ATM in the maintenance of genomic stability.

scholarly journals Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks

2005 ◽  
Vol 280 (15) ◽  
pp. 14709-14715 ◽  
Author(s):  
Benjamin P. C. Chen ◽  
Doug W. Chan ◽  
Junya Kobayashi ◽  
Sandeep Burma ◽  
Aroumougame Asaithamby ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Kinase ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Dependent Protein Kinase ◽  
Strand Breaks ◽  
Dependent Protein ◽  
Cell Cycle Dependence ◽  
Kinase Phosphorylation ◽  
Cycle Dependence

scholarly journals DNA-dependent Protein Kinase and XRCC4-DNA Ligase IV Mobilization in the Cell in Response to DNA Double Strand Breaks

2004 ◽  
Vol 280 (8) ◽  
pp. 7060-7069 ◽  
Author(s):  
Jérôme Drouet ◽  
Christine Delteil ◽  
Jacques Lefrançois ◽  
Patrick Concannon ◽  
Bernard Salles ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Double Strand Breaks ◽  
Dna Ligase ◽  
Dna Double Strand Breaks ◽  
Dependent Protein Kinase ◽  
Strand Breaks ◽  
Dna Ligase Iv ◽  
Ligase Iv ◽  
Dependent Protein

scholarly journals Role of PRKDC in cancer initiation, progression, and treatment

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yu Chen ◽  
Yi Li ◽  
Jiani Xiong ◽  
Bin Lan ◽  
Xuefeng Wang ◽  
...  
Keyword(s):  
Checkpoint Inhibitors ◽  
Double Strand Breaks ◽  
Nonhomologous End Joining ◽  
Dna Double Strand Breaks ◽  
End Joining ◽  
Strand Breaks ◽  
Cancer Initiation ◽  
Different Types ◽  
Dependent Protein

AbstractThe PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also closely related to the establishment of central immune tolerance and the maintenance of chromosome stability. The occurrence and development of different types of tumors and the results of their treatment are also influenced by DNA-PKcs, and it may also predict the results of radiotherapy, chemotherapy, and therapy with immune checkpoint inhibitors (ICIs). Here, we discuss and review the structure and mechanism of action of PRKDC and DNA-PKcs and their relationship with cancer.

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