scholarly journals The Histone Gene Cell Cycle Regulator HiNF-P Is a Unique Zinc Finger Transcription Factor with a Novel Conserved Auxiliary DNA-Binding Motif†

Biochemistry ◽  
2008 ◽  
Vol 47 (44) ◽  
pp. 11415-11423 ◽  
Author(s):  
Ricardo Medina ◽  
Timothy Buck ◽  
Sayyed K. Zaidi ◽  
Angela Miele-Chamberland ◽  
Jane B. Lian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Dna Binding ◽  
Zinc Finger ◽  
Histone Gene ◽  
Binding Motif ◽  
Zinc Finger Transcription Factor ◽  
Cell Cycle Regulator

scholarly journals Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor

2013 ◽  
Vol 42 (1) ◽  
pp. 276-289 ◽  
Author(s):  
J. Burdach ◽  
A. P. W. Funnell ◽  
K. S. Mak ◽  
C. M. Artuz ◽  
B. Wienert ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Zinc Finger ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Zinc Finger Transcription Factor

scholarly journals Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state

2012 ◽  
Vol 209 (9) ◽  
pp. 1583-1593 ◽  
Author(s):  
Matthew M. Meredith ◽  
Kang Liu ◽  
Alice O. Kamphorst ◽  
Juliana Idoyaga ◽  
Arito Yamane ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Transcription Factor ◽  
Steady State ◽  
Zinc Finger ◽  
Immune Cell ◽  
Negative Regulator ◽  
Binding Motif ◽  
Zinc Finger Transcription Factor ◽  
Mhc Molecules ◽  
Activation Pathways

Classical dendritic cells (cDCs) process and present antigens to T cells. Under steady-state conditions, antigen presentation by cDCs induces tolerance. In contrast, during infection or inflammation, cDCs become activated, express higher levels of cell surface MHC molecules, and induce strong adaptive immune responses. We recently identified a cDC-restricted zinc finger transcription factor, zDC (also known as Zbtb46 or Btbd4), that is not expressed by other immune cell populations, including plasmacytoid DCs, monocytes, or macrophages. We define the zDC consensus DNA binding motif and the genes regulated by zDC using chromatin immunoprecipitation and deep sequencing. By deleting zDC from the mouse genome, we show that zDC is primarily a negative regulator of cDC gene expression. zDC deficiency alters the cDC subset composition in the spleen in favor of CD8+ DCs, up-regulates activation pathways in steady-state cDCs, including elevated MHC II expression, and enhances cDC production of vascular endothelial growth factor leading to increased vascularization of skin-draining lymph nodes. Consistent with these observations, zDC protein expression is rapidly down-regulated after TLR stimulation. Thus, zDC is a TLR-responsive, cDC-specific transcriptional repressor that is in part responsible for preventing cDC maturation in the steady state.

scholarly journals Histone gene transcription factor binding in extracts of normal human cells.

1991 ◽  
Vol 11 (12) ◽  
pp. 5825-5831 ◽  
Author(s):  
F La Bella ◽  
N Heintz
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Dna Binding ◽  
Gene Transcription ◽  
Binding Activity ◽  
Histone Gene ◽  
Dna Binding Activity ◽  
Normal Human ◽  
Histone Gene Transcription

Transcriptional regulation of mammalian histone genes during S phase is achieved through activation of specific factors which interact with subtype-specific histone gene promoter sequences. It has previously been shown that in HeLa cells this induction is not mediated by obligatory changes in the DNA binding activity of histone gene transcription factors as cells progress through the cell cycle. Recently, it has been reported that the DNA binding properties of a putative histone gene transcription factor may be quite different in normal and transformed cells (J. Holthuis, T. A. Owen, A. J. van Wijnen, K. L. Wright, A. Ramsey-Ewing, M. B. Kennedy, R. Carter, S. C. Cosenza, K. J. Soprano, J. B. Lian, J. L. Stein, and G. S. Stein, Science 247:1454-1457, 1990). To determine whether the properties of well-characterized histone gene transcription factors are altered in transformed versus normal cells, we have examined the DNA binding activity of human histone transcription factors during the WI38 (a primary line of normal human fetal lung fibroblasts) cell cycle. The results demonstrate that the properties of Oct1, H4TF1, and H4TF2 are similar in WI38 and HeLa cells and that their DNA binding activities are constitutive during interphase of both normal and transformed cell lines. Although it remains possible that these factors are directly or indirectly perturbed as a result of cellular transformation, it appears unlikely that transformation results in gross changes in DNA binding activity as cells progress toward division.

Histone gene transcription factor binding in extracts of normal human cells

1991 ◽  
Vol 11 (12) ◽  
pp. 5825-5831
Author(s):  
F La Bella ◽  
N Heintz
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Dna Binding ◽  
Gene Transcription ◽  
Binding Activity ◽  
Histone Gene ◽  
Dna Binding Activity ◽  
Normal Human ◽  
Histone Gene Transcription

Transcriptional regulation of mammalian histone genes during S phase is achieved through activation of specific factors which interact with subtype-specific histone gene promoter sequences. It has previously been shown that in HeLa cells this induction is not mediated by obligatory changes in the DNA binding activity of histone gene transcription factors as cells progress through the cell cycle. Recently, it has been reported that the DNA binding properties of a putative histone gene transcription factor may be quite different in normal and transformed cells (J. Holthuis, T. A. Owen, A. J. van Wijnen, K. L. Wright, A. Ramsey-Ewing, M. B. Kennedy, R. Carter, S. C. Cosenza, K. J. Soprano, J. B. Lian, J. L. Stein, and G. S. Stein, Science 247:1454-1457, 1990). To determine whether the properties of well-characterized histone gene transcription factors are altered in transformed versus normal cells, we have examined the DNA binding activity of human histone transcription factors during the WI38 (a primary line of normal human fetal lung fibroblasts) cell cycle. The results demonstrate that the properties of Oct1, H4TF1, and H4TF2 are similar in WI38 and HeLa cells and that their DNA binding activities are constitutive during interphase of both normal and transformed cell lines. Although it remains possible that these factors are directly or indirectly perturbed as a result of cellular transformation, it appears unlikely that transformation results in gross changes in DNA binding activity as cells progress toward division.

Mechanism of DNA Binding by the ADR1 Zinc Finger Transcription Factor as Determined by SPR

2003 ◽  
Vol 329 (5) ◽  
pp. 931-939 ◽  
Author(s):  
Lawrence E. Schaufler ◽  
Rachel E. Klevit
Keyword(s):  
Transcription Factor ◽  
Dna Binding ◽  
Zinc Finger ◽  
Zinc Finger Transcription Factor

scholarly journals Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest

2009 ◽  
Vol 284 (9) ◽  
pp. 5574-5581 ◽  
Author(s):  
Tao Zhang ◽  
Wei-Dong Liu ◽  
Nicolle A. Saunee ◽  
Mary B. Breslin ◽  
Michael S. Lan
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Cyclin D1 ◽  
Cell Cycle Arrest ◽  
Zinc Finger ◽  
Zinc Finger Transcription Factor ◽  
Cycle Arrest

scholarly journals The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila

Development ◽  
2008 ◽  
Vol 135 (16) ◽  
pp. 2707-2716 ◽  
Author(s):  
N. Mitchell ◽  
N. Cranna ◽  
H. Richardson ◽  
L. Quinn
Keyword(s):  
Cell Cycle ◽  
Transcription Factor ◽  
Zinc Finger ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Zinc Finger Transcription Factor
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