Biodegradable and pH-Sensitive Hydrogels for Potential Colon-Specific Drug Delivery: Characterization and In Vitro Release Studies

2008 ◽  
Vol 9 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Maria Antonietta Casadei ◽  
Giovanna Pitarresi ◽  
Rossella Calabrese ◽  
Patrizia Paolicelli ◽  
Gaetano Giammona
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Ph Sensitive ◽  
Specific Drug ◽  
Release Studies ◽  
Colon Specific Drug Delivery ◽  
Vitro Release

scholarly journals Formulation and Evaluation of Colon Specific Drug Delivery of Press Coated Esomeprazole Tablets

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
G.R. Prasanna Laxmi ◽  
G. Srikanth
Keyword(s):  
Drug Delivery ◽  
Diffusion Mechanism ◽  
In Vitro Release ◽  
Specific Drug ◽  
Zero Order Kinetics ◽  
Colon Specific Drug Delivery ◽  
Enteric Coated ◽  
Vitro Release ◽  
Release Profiles

The basic aim of the present investigation is to formulate and evaluate colon specific press coated tablets of Esomeprazole .Esomeprazole tablets were successfully prepared using enteric coated polymers ethyl cellulose and HPMC pthallate by first preparing the core tablets and then press coated with polymers. study of the preformulation charcteristics and FTIR studies indicates that there was no interaction between Esomeprazole and excipients used  in the formulation .Invitro release profiles of optimized form of F6 were found to showed delayed release pattern in a very customized manner which was very much required for the colon specific drug delivery. . In vitro release profiles of optimized formulation of Esomeprazole controlled release tablets (F-6) were found to be improvised and followed zero - order kinetics, hence the release of the drug from the dosage form was independent of concentration and followed Higuchi model, and hence release of drug from press coated tablet was by diffusion mechanism. The drug delivery system was designed to deliver the drug at such a time when it was needed nocturnal time.

scholarly journals Influence of sterilization on the drug release behaviour of drug coated silicone

2021 ◽  
Vol 7 (2) ◽  
pp. 672-675
Author(s):  
Katharina Wulf ◽  
Stefan Raggl ◽  
Thomas Eickner ◽  
Gerrit Paasche ◽  
Niels Grabow
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Polymer Coating ◽  
Drug Loading ◽  
In Vitro Release ◽  
Physical Chemical ◽  
Release Studies ◽  
Vitro Release ◽  
Dual Drug

Abstract Sterilization processes ensure sterility of drug delivery systems, but may negatively affect the properties of biomaterials and incorporated drugs by changing their physical, chemical, mechanical properties and drug release behaviour. Therefore, it is important to investigate their influence. In this study, the influence of ethylene oxide (EtO) sterilization on the drug loading and release behaviour of incorporated Diclofenac (DCF) in a Poly-L-lactide (PLLA) coating and Dexamethasone (DMS) in the silicone carrier is presented. Silicone samples containing DMS were coated with PLLA containing DCF varying in layer thickness (5, 10, and 20 μm). Half of the samples underwent EtO sterilization, the other half was not sterilized. All un-/sterilized sample surfaces were in view of the morphology and hydrophilicity examined. Furthermore, in vitro release studies of DMS and DCF were conducted. The sterilized sample surfaces showed no morphological and hydrophilicity changes. The DCF and DMS loadings were similar for the sterile and untreated samples. This also applied to the in vitro DMS release profiles apart from the end of the studies where slight differences were evident. The results indicate that both drugs loaded in the polymer coating and the silicone were not impaired by the sterilization process. Thus, EtO sterilization appears suitable for DMS containing silicone and DCF incorporated PLLA coatings as a dual drug delivery system.

scholarly journals Development of pH-sensitive polycaprolactone-based microspheres for in vitro release studies of Triprolidine Hydrochloride

2014 ◽  
Vol 17 (7) ◽  
pp. 617-623 ◽  
Author(s):  
K. Sudhakar ◽  
K. Madhusudana Rao ◽  
P. Sudhakar ◽  
A. ChandraBabu ◽  
P. Kumara Babu ◽  
...  
Keyword(s):  
In Vitro Release ◽  
Ph Sensitive ◽  
Release Studies ◽  
Vitro Release
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