In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract

The basic aim of the present investigation is to formulate and evaluate colon specific press coated tablets of Esomeprazole .Esomeprazole tablets were successfully prepared using enteric coated polymers ethyl cellulose and HPMC pthallate by first preparing the core tablets and then press coated with polymers. study of the preformulation charcteristics and FTIR studies indicates that there was no interaction between Esomeprazole and excipients used in the formulation .Invitro release profiles of optimized form of F6 were found to showed delayed release pattern in a very customized manner which was very much required for the colon specific drug delivery. . In vitro release profiles of optimized formulation of Esomeprazole controlled release tablets (F-6) were found to be improvised and followed zero - order kinetics, hence the release of the drug from the dosage form was independent of concentration and followed Higuchi model, and hence release of drug from press coated tablet was by diffusion mechanism. The drug delivery system was designed to deliver the drug at such a time when it was needed nocturnal time.

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In Vitro Release Studies on Matrix Type Transdermal Drug Delivery Systems of Naltrexone and Its Acetyl Prodrug

Drug Development and Industrial Pharmacy ◽

10.1080/03639040500271944 ◽

2005 ◽

Vol 31 (9) ◽

pp. 871-877 ◽

Cited By ~ 15

Author(s):

Buchi N. Nalluri ◽

Caitlin Milligan ◽

Jianhong Chen ◽

Peter A. Crooks ◽

Audra L. Stinchcomb

Keyword(s):

Drug Delivery ◽

Transdermal Drug Delivery ◽

Drug Delivery Systems ◽

In Vitro Release ◽

Delivery Systems ◽

Matrix Type ◽

Release Studies ◽

Transdermal Drug Delivery Systems ◽

Vitro Release

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Montmorillonite-Alginate Nanocomposites as a Drug Delivery System: Intercalation and In Vitro Release of Vitamin B1 and Vitamin B6

Journal of Biomaterials Applications ◽

10.1177/0885328209344003 ◽

2009 ◽

Vol 25 (2) ◽

pp. 161-177 ◽

Cited By ~ 48

Author(s):

Bhavesh D. Kevadiya ◽

Ghanshyam V. Joshi ◽

Hasmukh A. Patel ◽

Pravin G. Ingole ◽

Haresh M. Mody ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Vitamin B6 ◽

In Vitro Release ◽

Vitamin B1 ◽

Vitro Release

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EFFECT OF NATURAL AND SYNTHETIC POLYMERS ON THE PROPERTIES OF CANDESARTAN CILEXETIL MATRIX TABLET PREPARED BY DRY GRANULATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2016.v9s3.14719 ◽

2016 ◽

Vol 9 (9) ◽

pp. 161

Author(s):

Omar Saeb Salih ◽

Roaa Abdalhameed Nief

Keyword(s):

Drug Delivery ◽

Candesartan Cilexetil ◽

Oral Drug Delivery ◽

In Vitro Release ◽

Oral Drug ◽

Matrix Tablet ◽

Sustained Release Formulation ◽

Weight Variation ◽

Vitro Release

ABSTRACTObjective: The objective of this study is to develop a controlled release matrix tablet of candesartan cilexetil to reduce the frequency of administration,enhance bioavailability and improve patient compliance; a once daily sustained release formulation of candesartan cilexetil is desirable.Methods: The prepared tablets from F1 to F24 were evaluated with different evaluation parameters like weight variation, drug content, friability,hardness, thickness and swelling ability. In vitro release for all formulas were studied depends on the type and amount of each polymer, i.e. (16 mg,32 mg and 48 mg) respectively beside to the combination effect of polymers on the release of the drug from the tablet.Results: In vitro release showed that formula 13 had the faster release (100% after 4 h) which contained acacia (1:1) and the lowest sustain releasewas showed for F7 (73% after 8 h) which contained HPMC K100M (1:1). Formula 1 was an 89 % release after 8 h which contain eudragit RS100; F4was a 100 % release after 5 h which contain Na CMC, F10 was a 100% after 8 h which contain xanthan gum and F16 was a 100 % release after 5 hwhich contain tragacanth polymer. Formula 9 had a lower release than F7 and F8 respectively. Formula 7 can be used for sustain oral drug delivery ofcandesartan cilexetil while Formula 13 can be used in contrary as fast release tablets for faster response.Conclusion: Controlled drug delivery system is promising for less dosing and higher patient compliance.Keywords: Angiotensin II receptor antagonist, Hypertension, Matrix system, Control release.

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