In vitro release dynamics of model drugs from psyllium and acrylic acid based hydrogels for the use in colon specific drug delivery

2008 ◽  
Vol 19 (8) ◽  
pp. 2771-2780 ◽  
Author(s):  
Baljit Singh ◽  
Ritu Bala ◽  
Nirmala Chauhan
Keyword(s):  
Drug Delivery ◽  
Acrylic Acid ◽  
In Vitro Release ◽  
Specific Drug ◽  
Colon Specific Drug Delivery ◽  
Vitro Release

Biodegradable and pH-Sensitive Hydrogels for Potential Colon-Specific Drug Delivery: Characterization and In Vitro Release Studies

2008 ◽  
Vol 9 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Maria Antonietta Casadei ◽  
Giovanna Pitarresi ◽  
Rossella Calabrese ◽  
Patrizia Paolicelli ◽  
Gaetano Giammona
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Ph Sensitive ◽  
Specific Drug ◽  
Release Studies ◽  
Colon Specific Drug Delivery ◽  
Vitro Release

scholarly journals Formulation and Evaluation of Colon Specific Drug Delivery of Press Coated Esomeprazole Tablets

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
G.R. Prasanna Laxmi ◽  
G. Srikanth
Keyword(s):  
Drug Delivery ◽  
Diffusion Mechanism ◽  
In Vitro Release ◽  
Specific Drug ◽  
Zero Order Kinetics ◽  
Colon Specific Drug Delivery ◽  
Enteric Coated ◽  
Vitro Release ◽  
Release Profiles

The basic aim of the present investigation is to formulate and evaluate colon specific press coated tablets of Esomeprazole .Esomeprazole tablets were successfully prepared using enteric coated polymers ethyl cellulose and HPMC pthallate by first preparing the core tablets and then press coated with polymers. study of the preformulation charcteristics and FTIR studies indicates that there was no interaction between Esomeprazole and excipients used  in the formulation .Invitro release profiles of optimized form of F6 were found to showed delayed release pattern in a very customized manner which was very much required for the colon specific drug delivery. . In vitro release profiles of optimized formulation of Esomeprazole controlled release tablets (F-6) were found to be improvised and followed zero - order kinetics, hence the release of the drug from the dosage form was independent of concentration and followed Higuchi model, and hence release of drug from press coated tablet was by diffusion mechanism. The drug delivery system was designed to deliver the drug at such a time when it was needed nocturnal time.

scholarly journals IN VITRO RELEASE OF HYDROCORTISONE BY GLYCINE-IMMOBILIZED EVAL MEMBRANE

2005 ◽  
Vol 17 (02) ◽  
pp. 86-90 ◽  
Author(s):  
PING-SHAN LAI ◽  
TAI-HORNG YOUNG ◽  
CHENG-YI WANG ◽  
MING-JIUM SHIEH
Keyword(s):  
Local Treatment ◽  
In Vitro Release ◽  
Permeation Rate ◽  
Specific Drug ◽  
Ph Values ◽  
Acid Environment ◽  
Colon Specific Drug Delivery ◽  
Poly Ethylene ◽  
Vitro Release

A pH-sensitive membrane for colon-specific drug delivery was prepared by glycine-immobilization on poly (ethylene-co-vinyl alcohol) (Gly-EVAL) that can enhance the permeability of hydrocortisone at pH 7.4 and resist drug permeation at pH 2.0 or in gastric juice. As the results of drug releasing profile, it is proposed that the electrical repulsion occurring between adjacent carboxylate ions at pH 7.4 on Gly-EVAL causes the higher permeation rate of hydrocortisone. Consequently, the hydrocortisone coated by Gly-EVAL can escape from degradation in acid environment and release significantly in neutral or weak basic pH values, which is ideally suitable for local treatment of ulcerative colitis.

Synthesis, characterization and evaluation of poly [glucose acrylate-methacrylic acid] hydrogels for colon-specific drug delivery

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Mehrdad Mahkam
Keyword(s):  
Drug Delivery ◽  
Methacrylic Acid ◽  
Aqueous Media ◽  
In Vitro Release ◽  
Water Soluble ◽  
Specific Drug ◽  
Aminosalicylic Acid ◽  
Gel Swelling ◽  
Colon Specific Drug Delivery

AbstractNew biodegradable polymeric hydrogels based on biocompatible materials, glucose acrylate (GA) and methacrylic acid (MAA) were designed and synthesized. In the first time, the glucose-6-acrylate-1,2,3,4-tetraacetate (GATA) monomer was prepared under mild conditions. The removal of protecting acetate groups from GATA will be carried out before the polymerization and then, the corresponding water soluble glycomonomer (GA) was obtained. This deprotected glycomonomer can be polymerized in aqueous media, which points to a way to obtain polymers with applications in biomedical and biochemical fields. Hydrogel synthesis was carried out by free-radical polymerization of the co-monomers using persulfate as an initiator and N,N′-methylenebisacrylamide as crosslinker. The hydrogels was characterized by FT-IR. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The swelling behaviour of the copolymers was dependent on the content of MAA groups and caused a decrease in gel swelling in pH 1 or an increase in gel swelling in pH 7.4. Model drug, 5-aminosalicylic acid (5-ASA) was entrapped into these hydrogels and the in vitro release profile of this drug was established separately in both enzyme-free SGF and SIF. Based on the great difference in swelling ratio at pH 1 and 7.4 for these hydrogels, it appears to be good candidates for colon-specific drug delivery.

Montmorillonite-Alginate Nanocomposites as a Drug Delivery System: Intercalation and In Vitro Release of Vitamin B1 and Vitamin B6

2009 ◽  
Vol 25 (2) ◽  
pp. 161-177 ◽  
Author(s):  
Bhavesh D. Kevadiya ◽  
Ghanshyam V. Joshi ◽  
Hasmukh A. Patel ◽  
Pravin G. Ingole ◽  
Haresh M. Mody ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Vitamin B6 ◽  
In Vitro Release ◽  
Vitamin B1 ◽  
Vitro Release
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