Quantitative Determination of Loadings and Oxidation Products of Polystyrene-Bound Phosphines Using31P MAS NMR

A new polarographic method for the determination of benzocaine and procaine based on the polarographic reduction of their chemically obtained oxidation products with potassium peroxymonosulfate is developed. Experimental conditions affecting quantitative yield of benzocaine and procaine oxidation products such as рH, oxidation time, reagents’ concentration, and temperature are explored. It is shown that the reduction current changes in a linear fashion (R=0.999) with increasing concentration of anesthetics over a concentration range of 1·10−6 - 5·10−5 mol L−1. The calculated limits of detection (LOD) for benzocaine and procaine are found to be 5.6·10−6 and 6·10−6 mol L−1, respectively. In the present study, quantitative polarographic determination of benzocaine in Farisil tablets and “Septolete Plus” lozenges and procaine in solution for injections is performed. The results of the analysis are in good agreement with the product specifications described in the quality certificates. The possibility of quantitative determination of benzocaine and procaine in pharmaceuticals is confirmed.

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Quantitative determination of hydroxy fatty acids as an indicator of in vivo lipid peroxidation: Oxidation products of arachidonic and docosapentaenoic acids in rat liver after exposure to carbon tetrachloride

Analytical Biochemistry ◽

10.1016/0003-2697(92)90377-j ◽

1992 ◽

Vol 206 (2) ◽

pp. 353-358 ◽

Cited By ~ 8

Author(s):

David W. Thomas ◽

Frederik J.G.M. van Kuijk ◽

Robert J. Stephens

Keyword(s):

Lipid Peroxidation ◽

Fatty Acids ◽

Carbon Tetrachloride ◽

Quantitative Determination ◽

Rat Liver ◽

Hydroxy Fatty Acids ◽

Oxidation Products

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Quantitative determination of the oxidation products of 2-isopropylnaphthalene by IR spectroscopy

Journal of Applied Spectroscopy ◽

10.1007/bf00606833 ◽

1971 ◽

Vol 14 (6) ◽

pp. 826-827

Author(s):

E. A. Kiva ◽

I. I. Shabalin ◽

G. N. Kirichenko

Keyword(s):

Ir Spectroscopy ◽

Quantitative Determination ◽

Oxidation Products

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Quantitative Determination of Antioxidants, after a Chromatographic Separation on Completely Acetylated Filter Paper. II. Determination of Some p-Phenylenediamine Derivatives

Rubber Chemistry and Technology ◽

10.5254/1.3542755 ◽

1957 ◽

Vol 30 (4) ◽

pp. 1172-1174

Author(s):

J. W. H. Zijp

Keyword(s):

Quantitative Determination ◽

Filter Paper ◽

Chromatographic Separation ◽

Oxidation Products ◽

Partition Chromatography ◽

Rubber Compound

Abstract In this paper methods are given for the quantitative determination of three antioxidants, viz., N,N′-diphenyl-p-phenylenediamine, N,N′-di-2-naphthyl-p-phenylenediamine and N-phenyl-N′-cyclohexyl-p-phenylenediamine. According to these methods the antioxidants are extracted from the rubber compound, separated by partition chromatography on completely acetylated filter paper and oxidized to the corresponding p-quinonediimines, after which these oxidation products are determined colorimetrically.

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