scholarly journals AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research

2014 ◽  
Vol 54 (4) ◽  
pp. 1050-1060 ◽  
Author(s):  
Haibin Liu ◽  
Lirong Wang ◽  
Mingliang Lv ◽  
Rongrong Pei ◽  
Peibo Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Target Identification ◽  
Domain Specific ◽  
Identification Research

scholarly journals Domain-specific cognitive effects of white matter pathology in old age, mild cognitive impairment and Alzheimer’s disease

2019 ◽  
Vol 27 (3) ◽  
pp. 453-470 ◽  
Author(s):  
Alar Kaskikallio ◽  
Mira Karrasch ◽  
Juha O. Rinne ◽  
Terhi Tuokkola ◽  
Riitta Parkkola ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Old Age ◽  
Cognitive Effects ◽  
Domain Specific ◽  
White Matter Pathology

scholarly journals Neuroanatomical and cognitive correlates of domain-specific anosognosia in early Alzheimer's disease

Cortex ◽  
2020 ◽  
Vol 129 ◽  
pp. 236-246 ◽  
Author(s):  
Jose Manuel Valera-Bermejo ◽  
Matteo De Marco ◽  
Micaela Mitolo ◽  
William J. McGeown ◽  
Annalena Venneri
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Correlates ◽  
Domain Specific ◽  
Early Alzheimer’S Disease

scholarly journals A domain-specific deficit for foodstuffs in patients with Alzheimer's disease

2002 ◽  
Vol 8 (7) ◽  
pp. 956-957 ◽  
Author(s):  
KEITH R. LAWS ◽  
VERITY C. LEESON ◽  
TIM M. GALE
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fruits And Vegetables ◽  
Domain Specific ◽  
Specific Composition ◽  
Living Things ◽  
Category Effects

Although some studies have reported a category specific naming deficit in Alzheimer's patients (invariably for living things), others have failed to replicate this finding (Laws et al., in press). Inconsistencies may partly stem from the fact that category effects are hidden in group analyses because individual Alzheimer's patients show category deficits in opposing directions, namely, some living and some nonliving (Gonnerman et al., 1997). Additionally, category effects may depend upon the specific composition of living things, such as the ratio of animals to fruits and vegetables, though this has never been explicitly examined. To examine this, we conducted a more detailed fractionation of living and nonliving categories for individual patients.

Impaired Awareness of Deficits in Alzheimer's Disease: The Role of Everyday Executive Dysfunction

2012 ◽  
Vol 19 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Martina Amanzio ◽  
Lene Vase ◽  
Daniela Leotta ◽  
Renato Miceli ◽  
Sara Palermo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Factor Analysis ◽  
Behavioral Assessment ◽  
Executive Dysfunction ◽  
Self Monitoring ◽  
Domain Specific ◽  
Impaired Awareness ◽  
Behavioral Domains

AbstractThe present study analyzed the awareness of deficits in 117 mild Alzheimer's disease participants. Since few studies have examined the cognitive and behavioral domains of reduced awareness in detail, we performed a domain-specific assessment using the Awareness of deficit Questionnaire – Dementia scale with the novel aim of describing the relationship with everyday executive dysfunction. Through the use of the subtests of the Behavioral Assessment of the Dysexecutive Syndrome, we hypothesized that executive cognitive functions may play an important role in the reduced awareness of deficits. We also considered other variables of interest to provide a novel comprehensive explanation of this phenomenon. Our first approach to the study was a factor analysis considering the role of these variables in the awareness of deficits; subsequently, regression analysis models were used to define which variables were associated with a reduction of awareness in cognitive and behavioral domains. In particular, the factors retained from the factor analysis, in terms of inhibition, self-monitoring, set-shifting, and mood orientation changes, appear to be important skills for awareness of instrumental activities of daily living (R2 = .32). We also found hypo manic mood orientation and a tendency through apathy to be prominent indications of reduced behavioral awareness (R2 = .13). (JINS, 2013, 18, –)

Alzheimer’s disease disrupts domain-specific and domain-general processes in numerosity estimation

2020 ◽  
Vol 42 (7) ◽  
pp. 690-709
Author(s):  
Angélique Roquet ◽  
Bernard François Michel ◽  
Patrick Lemaire
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Domain Specific ◽  
Numerosity Estimation

scholarly journals Data-driven FDG-PET subtypes of Alzheimer’s disease-related neurodegeneration

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Fedor Levin ◽  
◽  
Daniel Ferreira ◽  
Catharina Lange ◽  
Martin Dyrba ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Imaging ◽  
Fdg Pet ◽  
Executive Dysfunction ◽  
Data Driven ◽  
Regional Patterns ◽  
Domain Specific ◽  
Imaging Tool ◽  
Prodromal Ad

Abstract Background Previous research has described distinct subtypes of Alzheimer’s disease (AD) based on the differences in regional patterns of brain atrophy on MRI. We conducted a data-driven exploration of distinct AD neurodegeneration subtypes using FDG-PET as a sensitive molecular imaging marker of neurodegenerative processes. Methods Hierarchical clustering of voxel-wise FDG-PET data from 177 amyloid-positive patients with AD dementia enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) was used to identify distinct hypometabolic subtypes of AD, which were then further characterized with respect to clinical and biomarker characteristics. We then classified FDG-PET scans of 217 amyloid-positive patients with mild cognitive impairment (“prodromal AD”) according to the identified subtypes and studied their domain-specific cognitive trajectories and progression to dementia over a follow-up interval of up to 72 months. Results Three main hypometabolic subtypes were identified: (i) “typical” (48.6%), showing a classic posterior temporo-parietal hypometabolic pattern; (ii) “limbic-predominant” (44.6%), characterized by old age and a memory-predominant cognitive profile; and (iii) a relatively rare “cortical-predominant” subtype (6.8%) characterized by younger age and more severe executive dysfunction. Subtypes classified in the prodromal AD sample demonstrated similar subtype characteristics as in the AD dementia sample and further showed differential courses of cognitive decline. Conclusions These findings complement recent research efforts on MRI-based identification of distinct AD atrophy subtypes and may provide a potentially more sensitive molecular imaging tool for early detection and characterization of AD-related neurodegeneration variants at prodromal disease stages.

White Matter Hyperintensities and Cognition in Mild Cognitive Impairment and Alzheimer’s Disease: A Domain-Specific Meta-Analysis

2018 ◽  
Vol 63 (2) ◽  
pp. 515-527 ◽  
Author(s):  
Esther van den Berg ◽  
Mirjam I. Geerlings ◽  
Geert Jan Biessels ◽  
Paul J. Nederkoorn ◽  
Raoul P. Kloppenborg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Meta Analysis ◽  
Domain Specific

Anosognosia in Alzheimer’s disease: The role of impairment levels in assessment of insight across domains

2010 ◽  
Vol 16 (3) ◽  
pp. 463-473 ◽  
Author(s):  
HANNA LEICHT ◽  
MARTIN BERWIG ◽  
HERMANN-JOSEF GERTZ
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuropsychological Tests ◽  
Control Sample ◽  
Self Assessment ◽  
Domain Specific ◽  
Clinical Rating ◽  
Healthy Control ◽  
And Performance

AbstractImpaired insight for deficits (anosognosia) is common in Alzheimer’s disease (AD). However, it has not yet been determined clearly (a) whether different methods for assessing insight are comparable, and (b) whether anosognosia affects different domains to different degrees (domain-specificity). Impaired insight was investigated in 32 patients with AD, who were each accompanied by a caregiver. Anosognosia was assessed by a global clinical rating, questionnaire discrepancies (patient vs. caregiver) covering different domains, and performance discrepancies (self-assessment vs. performance) based on four neuropsychological tests which were compared with those of a healthy control sample. The results of clinical rating and questionnaire discrepancies were closely correlated, but performance discrepancies showed no association with the other methods. Anosognosia was present in the majority of the sample, and occurred across domains. The domains corresponding to core deficits in AD (recent memory, activities of daily living) appeared especially prone to anosognosia. However, results do not suggest that anosognosia itself is domain-specific. Rather, it appears that insight may be invariant, while differences in patient-caregiver discrepancies arise largely from different degrees of deficit across domains. (JINS, 2010, 16, 463–473.)

Sign in / Sign up

Export Citation Format

Share Document