Effects of Process Variables on the Properties of Spray-Dried Mannitol and Mannitol/Disodium Cromoglycate Powders Suitable for Drug Delivery by Inhalation

2011 ◽  
Vol 50 (24) ◽  
pp. 13922-13931 ◽  
Author(s):  
Katarzyna Kramek-Romanowska ◽  
Marcin Odziomek ◽  
Tomasz R. Sosnowski ◽  
Leon Gradoń
Keyword(s):  
Drug Delivery ◽  
Disodium Cromoglycate ◽  
Process Variables ◽  
Spray Dried ◽  
Spray Dried Mannitol

scholarly journals Physico-Chemical and In Vitro Characterization of Chitosan-Based Microspheres Intended for Nasal Administration

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 608
Author(s):  
Csilla Bartos ◽  
Patrícia Varga ◽  
Piroska Szabó-Révész ◽  
Rita Ambrus
Keyword(s):  
Drug Delivery ◽  
Spray Drying ◽  
Process Parameters ◽  
Sodium Tripolyphosphate ◽  
Structural Characteristics ◽  
Nasal Administration ◽  
Drug Bioavailability ◽  
Intranasal Application ◽  
Spray Dried

The absorption of non-steroidal anti-inflammatory drugs (NSAIDs) through the nasal epithelium offers an innovative opportunity in the field of pain therapy. Thanks to the bonding of chitosan to the nasal mucosa and its permeability-enhancing effect, it is an excellent choice to formulate microspheres for the increase of drug bioavailability. The aim of our work includes the preparation of spray-dried cross-linked and non-cross-linked chitosan-based drug delivery systems for intranasal application, the optimization of spray-drying process parameters (inlet air temperature, pump rate), and the composition of samples. Cross-linked products were prepared by using different amounts of sodium tripolyphosphate. On top of these, the micrometric properties, the structural characteristics, the in vitro drug release, and the in vitro permeability of the products were studied. Spray-drying resulted in micronized chitosan particles (2–4 μm) regardless of the process parameters. The meloxicam (MEL)-containing microspheres showed nearly spherical habit, while MEL was present in a molecularly dispersed state. The highest dissolved (>90%) and permeated (~45 µg/cm2) MEL amount was detected from the non-cross-linked sample. Our results indicate that spray-dried MEL-containing chitosan microparticles may be recommended for the development of a novel drug delivery system to decrease acute pain or enhance analgesia by intranasal application.

Pullulan-modified spray-dried powders for pulmonary drug delivery

2015 ◽  
Vol 213 ◽  
pp. e30-e31 ◽  
Author(s):  
Enyu Xu ◽  
Wangzhan Jiang ◽  
Ying Xu ◽  
Yang Cai ◽  
Haoying Li
Keyword(s):  
Drug Delivery ◽  
Pulmonary Drug Delivery ◽  
Spray Dried

scholarly journals Impact of process variables on the micromeritic and physicochemical properties of spray-dried microparticles - Part II. Physicochemical characterisation of spray-dried materials

2012 ◽  
Vol 64 (11) ◽  
pp. 1583-1591 ◽  
Author(s):  
Krzysztof J. Paluch ◽  
Lidia Tajber ◽  
Maria I. Amaro ◽  
Owen I. Corrigan ◽  
Anne Marie Healy
Keyword(s):  
Physicochemical Properties ◽  
Process Variables ◽  
Physicochemical Characterisation ◽  
Spray Dried

Process optimization of spray-dried fanhuncaoin powder for pulmonary drug delivery and its pharmacokinetic evaluation in rats

2018 ◽  
Vol 44 (8) ◽  
pp. 1357-1370
Author(s):  
Xiaobo Wang ◽  
Yinan Wang ◽  
Ronggang Xi ◽  
Yuanyuan Wang ◽  
Xiaobo Yang
Keyword(s):  
Drug Delivery ◽  
Process Optimization ◽  
Pulmonary Drug Delivery ◽  
Spray Dried ◽  
Pharmacokinetic Evaluation

scholarly journals SPRAY DRIED LACTOSE BASED PRONIOSOMES AS STABLE PROVESICULAR DRUG DELIVERY CARRIERS: SCREENING, FORMULATION, AND PHYSICOCHEMICAL CHARACTERIZATION

2018 ◽  
Vol 10 (5) ◽  
pp. 125 ◽  
Author(s):  
Ali Nasr ◽  
Mona Qushawy ◽  
Shady Swidan
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Zeta Potential ◽  
Oral Drug Delivery ◽  
Physicochemical Characterization ◽  
Water Soluble ◽  
Oral Drug ◽  
Flow Properties ◽  
Poorly Water Soluble ◽  
Spray Dried

Objective: In the present investigation efforts were considered to optimize the different conditions for the preparation of spray dried lactose based proniosomes. The aim of this research was to investigate the feasibility of proniosomes as stable precursors for the development of niosomes as oral drug delivery system for poorly water-soluble drugs.Methods: A total of twenty-eight plain proniosomal formulae were prepared with various surfactant-cholesterol loading ratios in each formula using spray dried lactose as a carrier. Span 20, 40, 60 and 80 were used in various molar ratios with cholesterol. Different evaluation techniques were performed to study the performance of the prepared proniosomes. The micromeritic properties of the prepared proniosomes were analyzed. The reconstituted niosomes were further evaluated for morphological characterization using transmission electron microscope (TEM), particle size analysis, zeta potential, and polydispersity index (PDI). Finally, selected proniosomal formulae were tested for stability study.Results: The proniosomal formulae prepared using span 40 and span 60 exhibited excellent flowability while those prepared with span 20 and span 80 showed poor flow properties. TEM photographs revealed that the vesicles were discrete, spherical without aggregation. The mean vesicle size of reconstituted niosomes was found to be in the range between (252.9±0.43–624.3±0.23 nm) with perfect PDI values (0.387±0.05–0.835±0.03). The negative values of zeta potential indicated that all prepared formulae were stabilized by electrostatic repulsion forces. Stability studies confirmed that proniosomes give a more stable system that could overcome the problems of standard niosomes. Formulae with the smallest particle size, higher surface charge values and best flow properties were selected to be loaded with poorly soluble drugs for further study.Conclusion: The obtained results offered evidence that spray-dried lactose based proniosomes are promising stable drug delivery carriers and ready to incorporate various poorly water-soluble drugs in order to improve their limited oral bioavailability.

scholarly journals Advanced spray dried proliposomes of amphotericin B lung surfactant-mimic phospholipid microparticles/nanoparticles as dry powder inhalers for targeted pulmonary drug delivery

2020 ◽  
Vol 64 ◽  
pp. 101975
Author(s):  
Alexan I. Gomez ◽  
Maria F. Acosta ◽  
Priya Muralidharan ◽  
Jason X.-J Yuan ◽  
Stephen M. Black ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amphotericin B ◽  
Lung Surfactant ◽  
Pulmonary Drug Delivery ◽  
Dry Powder Inhalers ◽  
Dry Powder ◽  
Spray Dried

scholarly journals Preparation and comparison of spray dried and electrospun bioresorbable drug delivery systems

2015 ◽  
Vol 68 ◽  
pp. 671-679 ◽  
Author(s):  
Péter L. Sóti ◽  
Zsombor K. Nagy ◽  
Geert Serneels ◽  
Balázs Vajna ◽  
Attila Farkas ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Spray Dried
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