THE COLORED SALTS OF SCHIFF'S BASES. II. THE HYDROCHLORIDES OF BASES FORMED BY CONDENSING p-AMINODIPHENYLAMINE WITH AROMATIC ALDEHYDES.

Background: The role of small molecules as antioxidants to prevent the oxidation of other molecules and inhibit them from radical formation is the area of much interest to cure disease especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation of fuels and lubricants. Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for 2-10 min. Results: Our present study showed that all compounds are better ferrous ion-chelating agents except compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 = 329.26 ± 4.75 µM) which has slightly low activity than the standard EDTA (IC50 = 318.40 ± 5.53 μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity than the standard. However, remaining four compounds showed comparable radical scavenging activity to the standard DPPH (IC50 = 257.77 ± 4.60 µM). Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants. From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential to serve as leads for the development of antioxidant agents for future research.

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Synthesis of Some New Azetidinone Derivatives Containing Aryl Sulfonyloxy Group

E-Journal of Chemistry ◽

10.1155/2004/258752 ◽

2004 ◽

Vol 1 (4) ◽

pp. 194-198

Author(s):

H. S. Patel ◽

H. D. Desai

Keyword(s):

Sodium Salt ◽

Acetyl Chloride ◽

Condensation Reaction ◽

Aromatic Aldehydes ◽

Schiff’S Bases ◽

Aniline Derivative ◽

Schiff's Bases

Some novel azetidinone derivatives containing aryl sulfonyloxy group have been prepared. The 4-sulfonyloxy aniline derivative (2) has been prepared by reaction of 4-nitro phenol (sodium salt) with N-acetyl sulfanilyl chloride (ASC) followed by hydrolysis by ethanolic HCl. This compound (2) undergoes facile condensation reaction with aromatic aldehydes to yield different Schiff’s bases (3a-h). Cyclocondensation of compounds (3a-h) with chloro acetyl chloride yields different 2-azetidinone derivatives (4a-h).

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Synthesis, characterization and anti-bacterial activity of novel schiff bases of pyridin-3 yl-carbohydrazide derivatives

Journal of Innovations in Applied Pharmaceutical Science (JIAPS) ◽

10.37022/jiaps.v6i2.234 ◽

2021 ◽

pp. 23-26

Author(s):

Ravi Kumar Konda ◽

Anish Kumar K ◽

Phani Lakshman M ◽

Mohammed Asif ◽

Anusha Reddy D

Keyword(s):

Antibacterial Activity ◽

Schiff Base ◽

Schiff Bases ◽

Wide Spectrum ◽

Cyclic Compound ◽

Aromatic Aldehydes ◽

Bacterial Activity ◽

Schiff’S Bases ◽

Ethyl Nicotinate ◽

Schiff's Bases

Heterocyclic compounds are cyclic compounds containing carbon and other heteroatoms. The most common heteroatoms are oxygen, nitrogen, and Sulphur. A heterocyclic compound is a cyclic compound that has atoms at least two different elements as members of its ring. A Schiff base (azomethine) is named after its inventor, Hugo Schiff and it is a functional group that contains a carbon-nitrogen double bond with the nitrogen atom connected to an aryl or alkyl group but not hydrogen. Schiff bases of Pyridin-3 yl-carbohydrazide derivatives from ethyl nicotinate and different aromatic aldehydes. Schiff’s bases are aromatic substituted imine compounds. These compounds are very important in the medicinal and pharmaceutical fields because of their wide spectrum of biological activity. Schiff’s bases show antibacterial activity, antifungal activity, and also antitumor activity. Aromatic aldehydes were refluxed with ethyl nicotinate using ethanol as a solvent to form Schiff's bases. All chemicals are taken in equimolar concentrations. The synthesized compounds were characterized by melting point, solubility, percentage yield, TLC, and IR spectral analysis. All derivatives are evaluated for anti-bacterial activity by the cup plate method. The antibacterial activity of test compounds was compared against standard Streptomycin. The 5 synthesized compounds show moderate antimicrobial activity. The experimental work summarizes the synthesis and in-vitro antibacterial activity of Schiff base derivatives.

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Schiff's bases derived from l-lysine and aromatic aldehydes as green corrosion inhibitors for mild steel: Experimental and theoretical studies

Journal of Molecular Liquids ◽

10.1016/j.molliq.2015.12.027 ◽

2016 ◽

Vol 215 ◽

pp. 47-57 ◽

Cited By ~ 91

Author(s):

Neeraj Kumar Gupta ◽

Chandrabhan Verma ◽

M.A. Quraishi ◽

A.K. Mukherjee

Keyword(s):

Mild Steel ◽

Corrosion Inhibitors ◽

Aromatic Aldehydes ◽

Theoretical Studies ◽

Schiff’S Bases ◽

Schiff's Bases ◽

Experimental And Theoretical Studies ◽

Green Corrosion Inhibitors

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Synthesis and Antimicrobial Activity of Some 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl- 1H-imidazolin-5(4H)-one Compounds

Oriental Journal Of Chemistry ◽

10.13005/ojc/350245 ◽

2019 ◽

Vol 35 (2) ◽

pp. 822-828

Author(s):

Cong Tien Nguyen ◽

Dao Thi Hong Dinh ◽

Thin Van Nguyen ◽

Giang Duc Le ◽

Hien Cao Nguyen

Keyword(s):

Antimicrobial Activity ◽

Hydrazine Hydrate ◽

Spectral Data ◽

1H Nmr ◽

Aromatic Aldehydes ◽

Antimicrobial Activities ◽

Gram Negative Bacteria ◽

Schiff’S Bases ◽

Gram Negative ◽

Schiff's Bases

4-Chlorobenzylidene-2-methyl-(4H)-oxazol-5-one, which were prepared from 4-chlorobenzaldehyde and acetylglycine in reaction with hydrazine hydrate in ethanol gave 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one. However, treatment of 4-chlorobenzylidene-2-methyl-(4H)-oxazol-5-one with hydrazine hydrate in pyridine yielded 3-(4-chlorophenyl)propanohydrazide. Reaction of 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one with aromatic aldehydes gave eight corresponding Schiff’s bases namely 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-ones. The structure of the 3-(4-chlorophenyl)propanohydrazide and the imidazoline-5-one compounds was confirmed by IR, 1H-NMR and MS spectral data. The Schiff’s bases were tested for antimicrobial activities against several strains of Gram-positive, Gram-negative bacteria, molds and yeasts.

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The synthesis and antimicrobial study of some azetidinone derivatives with the para-anisidine moiety

Journal of the Serbian Chemical Society ◽

10.2298/jsc0705437b ◽

2007 ◽

Vol 72 (5) ◽

pp. 437-442 ◽

Cited By ~ 8

Author(s):

Ishwar Bhat ◽

Sunil Chaithanya ◽

P.D. Satyanarayana ◽

Balakrishna Kalluraya

Keyword(s):

1H Nmr ◽

Spectroscopic Analysis ◽

Aromatic Aldehydes ◽

Chloroacetyl Chloride ◽

Schiff’S Bases ◽

Antimicrobial Study ◽

Schiff's Bases ◽

Agar Disc ◽

Antifungal Potential ◽

Antibacterial And Antifungal

Azetidinones were synthesized from p-anisidine in two steps. First the Schiff's bases were prepared by reacting the hydrazide of an anisidine derivative with different aromatic aldehydes. Cyclocondensation of the Schiff's bases with chloroacetyl chloride in the presence of triethylamine resulted in the formation of the corresponding azetidinone analogues. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis. The antibacterial and antifungal potential of the synthesized compounds were evaluated by the agar disc method.

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