scholarly journals Synthesis and Antimicrobial Activity of Some 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl- 1H-imidazolin-5(4H)-one Compounds

2019 ◽  
Vol 35 (2) ◽  
pp. 822-828
Author(s):  
Cong Tien Nguyen ◽  
Dao Thi Hong Dinh ◽  
Thin Van Nguyen ◽  
Giang Duc Le ◽  
Hien Cao Nguyen
Keyword(s):  
Antimicrobial Activity ◽  
Hydrazine Hydrate ◽  
Spectral Data ◽  
1H Nmr ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Gram Negative Bacteria ◽  
Schiff’S Bases ◽  
Gram Negative ◽  
Schiff's Bases

4-Chlorobenzylidene-2-methyl-(4H)-oxazol-5-one, which were prepared from 4-chlorobenzaldehyde and acetylglycine in reaction with hydrazine hydrate in ethanol gave 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one. However, treatment of 4-chlorobenzylidene-2-methyl-(4H)-oxazol-5-one with hydrazine hydrate in pyridine yielded 3-(4-chlorophenyl)propanohydrazide. Reaction of 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one with aromatic aldehydes gave eight corresponding Schiff’s bases namely 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-ones. The structure of the 3-(4-chlorophenyl)propanohydrazide and the imidazoline-5-one compounds was confirmed by IR, 1H-NMR and MS spectral data. The Schiff’s bases were tested for antimicrobial activities against several strains of Gram-positive, Gram-negative bacteria, molds and yeasts.

scholarly journals Synthesis of Novel 3-Acetyl N-methyl-2- Quinolone Derivatives with Expected Antimicrobial Activity

2018 ◽  
Vol 28 (2) ◽  
pp. 73
Author(s):  
Ghazwan Ali Salman
Keyword(s):  
Antimicrobial Activity ◽  
Hydrazine Hydrate ◽  
Schiff Bases ◽  
1H Nmr ◽  
13C Nmr ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Aryl Aldehydes ◽  
Ft Ir ◽  
Quinolone Derivatives

A series of new 3-Acetyl N-Methyl-2-quinolones oxadiazoles derivatives were synthesized by reaction of 3-acetyl-4-hydroxy-1-methylquinolin-2(1H)-one 3 with ethylbromoacetate to produce compounds 4. The hydrazinolysis of compound 4 with hydrazine hydrate afforded hydrazide compounds 5. New Schiff bases 6 were obtained by condensation of compound 5 with different aryl aldehydes. The last step involves refluxing compound 6 with acetic anhydrides to give the corresponding 3-acetyl-N-methylquinolin-2-one oxadiazoles 7. All the synthesized compounds were characterized on the basis of FT-IR, 1H-NMR and 13C-NMR. The synthesized compounds have been evaluated for antimicrobial activity against Gram-positive and Gram-negative bacteria. Among sixteen synthesized novel compounds, in which five compounds (7a, 7b, 7c, 7e, 7g) ex-hibited promising Antimicrobial activity as compared to Trimethoprim (100μg/ml).

scholarly journals Synthesis of New Furothiazolo Pyrimido Quinazolinones from Visnagenone or Khellinone and Antimicrobial Activity

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2793 ◽  
Author(s):  
Ameen Abu-Hashem
Keyword(s):  
Antimicrobial Activity ◽  
Growth Inhibition ◽  
Spectral Data ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Heterocyclic Compounds ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Bacteria And Fungi ◽  
New Compounds

Substituted-6-methyl-1-thioxo-1,2-dihydro-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-ones (5a,b) were synthesized from condensation of visnagenone (2a) or khellinone (2b) with 6-amino-thiouracil (3) in dimethylformamide or refluxing of (4a) or (4b) in dimethylformamide. Hence, compounds (5a,b) were used as the starting materials for preparing many new heterocyclic compounds such as; furo[3,2-g]pyrimido[1,6-a]quinazoline (6a,b), furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazolinone (7a,b), substituted-benzylidene-furo[3,2-g]thiazolo[2′,3′:2,3]pyrimido[1,6-a]quinazoline-3,5-dione (8a–f), 3-oxo-furo[3,2-g]pyrimido[1,6-a]quinazoline-pentane-2,4-dione (9a,b), 1-(pyrazole)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (10a,b), 2-(oxo or thioxo)-pyrimidine-furo[3,2-g]pyrimido[1,6-a]quinazolinone (11a–d), 1-(methylthio)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (12a,b), 1-(methyl-sulfonyl)-furo[3,2-g]pyrimido[1,6-a]quinazolinone (13a,b) and 6-methyl-1-((piperazine) or morpholino)-3H-furo[3,2-g]pyrimido[1,6-a]quinazolin-3-one (14a–d). The structures of the prepared compounds were elucidated on the basis of spectral data (IR, 1H-NMR, 13C-NMR, MS) and elemental analysis. Antimicrobial activity was evaluated for the synthesized compounds against Gram-positive, Gram-negative bacteria and fungi. The new compounds, furothiazolo pyrimido quinazolines 8a–f and 11a–d displayed results excellent for growth inhibition of bacteria and fungi.

scholarly journals Antimicrobial Activity of Lignin and Lignin-Derived Cellulose and Chitosan Composites Against Selected Pathogenic and Spoilage Microorganisms

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 670 ◽  
Author(s):  
Alzagameem ◽  
Klein ◽  
Bergs ◽  
Do ◽  
Korte ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Low Temperatures ◽  
Food Packaging ◽  
Antimicrobial Activities ◽  
Gram Negative Bacteria ◽  
Scavenging Activity ◽  
Gram Positive ◽  
Gram Negative ◽  
Spoilage Bacteria ◽  
Chitosan Films

The antiradical and antimicrobial activity of lignin and lignin-based films are both of great interest for applications such as food packaging additives. The polyphenolic structure of lignin in addition to the presence of O-containing functional groups is potentially responsible for these activities. This study used DPPH assays to discuss the antiradical activity of HPMC/lignin and HPMC/lignin/chitosan films. The scavenging activity (SA) of both binary (HPMC/lignin) and ternary (HPMC/lignin/chitosan) systems was affected by the percentage of the added lignin: the 5% addition showed the highest activity and the 30% addition had the lowest. Both scavenging activity and antimicrobial activity are dependent on the biomass source showing the following trend: organosolv of softwood > kraft of softwood > organosolv of grass. Testing the antimicrobial activities of lignins and lignin-containing films showed high antimicrobial activities against Gram-positive and Gram-negative bacteria at 35 °C and at low temperatures (0–7 °C). Purification of kraft lignin has a negative effect on the antimicrobial activity while storage has positive effect. The lignin release in the produced films affected the activity positively and the chitosan addition enhances the activity even more for both Gram-positive and Gram-negative bacteria. Testing the films against spoilage bacteria that grow at low temperatures revealed the activity of the 30% addition on HPMC/L1 film against both B. thermosphacta and P. fluorescens while L5 was active only against B. thermosphacta. In HPMC/lignin/chitosan films, the 5% addition exhibited activity against both B. thermosphacta and P. fluorescens.

scholarly journals Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones

2005 ◽  
Vol 2 (2) ◽  
pp. 109-112
Author(s):  
A. K. Parekh ◽  
K. K. Desai
Keyword(s):  
Antibacterial Activity ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Aromatic Aldehydes ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
H Nmr

Some new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and1H NMR spectral data. They have been screened for their antibacterial activity against Gram positive bacteria B. subtillis & S. aureus and Gram negative bacteria E. coli & S. typhi.

scholarly journals ANTIMICROBIAL ACTIVITIES OF ARTABOTRYS ODORATISSIMUS R.Br.

2021 ◽  
Vol 3 (1) ◽  
pp. 1-5
Author(s):  
Poonam Sethi ◽  
Nandhagopal Karmegam
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Pseudomonas Fluorescens ◽  
Methanolic Extract ◽  
Antimicrobial Activities ◽  
Experimental Plant ◽  
Gram Negative Bacteria ◽  
Zone Of Inhibition ◽  
Gram Negative ◽  
Good Antibacterial Activity

ABSTRACT Artabotrys odoratissimus R.Br.  (Annonaceae) a medium sizes shrub with hooks, sweet smelling flowers and aggregate fruits, was tested for activity against gram negative bacteria. The fruit of the experimental plant was extracted with water, methanol and toluene: methanol (2:1 v/v). Artabotrys fruits showed good antibacterial activity and produced zone of inhibition of 32mm. The methanolic extract of the fruit showed maximum zone of inhibition at 300 ?g/ml against Pseudomonas fluorescens. The present study clearly indicates that A. odoratissimus had a profound antimicrobial   activity and it may be useful in the treatment of various infectious caused by bacteria. Keywords: Artabotrys, Gram Negative Bacteria, Pseudomonas, Zone Of Inhibition

scholarly journals Lipid Segregation Explains Selective Toxicity of a Series of Fragments Derived from the Human Cathelicidin LL-37

2009 ◽  
Vol 53 (9) ◽  
pp. 3705-3714 ◽  
Author(s):  
Raquel F. Epand ◽  
Guangshun Wang ◽  
Bob Berno ◽  
Richard M. Epand
Keyword(s):  
Antimicrobial Activity ◽  
Bacterial Species ◽  
Antimicrobial Activities ◽  
Gram Negative Bacteria ◽  
Selective Toxicity ◽  
Gram Positive ◽  
Gram Negative ◽  
Cytoplasmic Membranes ◽  
Anionic Lipids ◽  
Active Segment

ABSTRACT The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity against both gram-positive and gram-negative bacteria. We studied the ability of several fragments of LL-37, exhibiting different antimicrobial activities, to interact with membranes whose compositions mimic the cytoplasmic membranes of gram-positive or of gram-negative bacteria. These fragments are as follows: KR-12, the smallest active segment of LL-37, with the sequence KRIVQRIKDFLR, which exhibits antimicrobial activity only against gram-negative bacteria; a slightly smaller peptide, RI-10, missing the two cationic residues at the N and C termini of KR-12, which has been shown not to have any antimicrobial activity; a longer peptide, GF-17, which shows antimicrobial activity against gram-positive as well as gram-negative bacteria; and GF-17D3, with 3 d-amino-acid residues, which is also selective only for gram-negative bacteria. Those fragments with the capacity to cluster anionic lipids away from zwitterionic lipids in a membrane exhibit selective toxicity toward bacteria containing zwitterionic as well as anionic lipids in their cytoplasmic membranes but not toward bacteria with only anionic lipids. This finding allows for the prediction of the bacterial-species selectivity of certain agents and paves the way for designing new antimicrobials targeted specifically toward gram-negative bacteria.

scholarly journals Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)-thione

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Nasser M. Abd El-Salam ◽  
Mohamed S. Mostafa ◽  
Gamal A. Ahmed ◽  
Othman Y. Alothman
Keyword(s):  
Antimicrobial Activity ◽  
Heterocyclic Compounds ◽  
Antimicrobial Activities ◽  
Ring System ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative

Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized starting from 6-chloropyridazin3-(2H)-thione. Some disulfide and sulfide derivatives were also prepared. The antimicrobial activity of the synthesized compounds was tested. Some of these compounds possess a highly response against gram-positive and gram-negative bacteria as well as fungi.

Antimicrobial activities of Antarctic sponges

1992 ◽  
Vol 4 (2) ◽  
pp. 179-183 ◽  
Author(s):  
J.B. McClintock ◽  
J.J. Gauthier
Keyword(s):  
Antimicrobial Activity ◽  
Growth Inhibition ◽  
Antimicrobial Activities ◽  
Marine Sponges ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Strong Activity ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Antarctic Marine

Methanol-toluene extracts of 17 common Antarctic marine sponges collected from shallow waters in McMurdo Sound in October–December 1989 were tested for suppression of growth of bacteria (gram-positive and negative), yeasts and fungi. Weak to moderate levels of antimicrobial activity occurred in all sponges. Antimicrobial activity was more common when gram-negative bacteria were exposed to sponge extracts; 47% of the sponge extracts caused growth inhibition in one or more gram-positive bacteria, while 100% of the extracts caused growth inhibition in gram-negative bacteria. Particularly strong activity was observed against two species of gram-positive bacteria exposed to extracts of the sponge Latrunculia apicalis and against one strain of gram-negative bacterium exposed to extracts of the sponge Haliclona sp. Antimicrobial responses against yeasts and fungi were generally non-existent or weak, with the exception of the yeast Candida tropicalis, which was strongly inhibited by extracts of the sponges Homaxonella balfourensis, Dendrilla membranosa, Kirkpatrickia variolosa, Gellius benedeni, Cinachyra antarctica and Scolymastia joubinia. Antimicrobial activity in these polar sponges is widespread but generally weaker than that found in temperate and tropical sponges.

scholarly journals Synthesis and Antimicrobial Schreening of New 4,5,6,7-Tatra Hydro Benzo Thiophene Derivatives

2019 ◽  
Vol 16 (1) ◽  
pp. 0068
Author(s):  
Zainab Ali
Keyword(s):  
Spectral Data ◽  
Schiff Bases ◽  
Antimicrobial Activities ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Ft Ir ◽  
Thiophene Derivatives

A group of derivatives for compounds 2-Amino-3-carboxy-4,5,6,7-tetra hydrobenz -othiophene bearing different heterocyclic moieties such as Schiff bases. B-Lactum, 4-thiazolidinone.1,3-oxazepan. The newly synthesized derivatives have been supported by spectral data FT-IR, H1-NMR. All the synthesized compounds were screened for their antimicrobial activities against gram-positive and gram-negative bacteria as reference.

scholarly journals Metal complexes of Schiff’s bases derived from 3-(arylazo)-2,4- -pentanediones with 2-aminophenol and 2-aminothiophenol

2007 ◽  
Vol 72 (11) ◽  
pp. 1075-1084 ◽  
Author(s):  
K. Krishnankutty ◽  
P. Sayudevi ◽  
Basheer Ummathur
Keyword(s):  
Metal Complexes ◽  
Spectral Data ◽  
1H Nmr ◽  
Analytical Data ◽  
Tetradentate Ligand ◽  
Carbonyl Groups ◽  
Schiff’S Bases ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Schiff's Bases

Phenylazo- and thiazolylazo-2,4-pentanediones on reaction with 2-aminophenol and 2-aminothiophenol yielded a new series of polydentate Schiff?s base ligands. The structure and tautomeric nature of these compounds and their metal complexes were established on the basis of their IR, 1H-NMR and mass spectral data. The spectral and analytical data revealed the condensation of both carbonyl groups of 3-(2-thiazolylazo)- 2,4-pentanedione with 2-aminophenol to form an N2O2 tetradentate ligand. Details on the formation of its [ML] complexes with Ni(II), Cu(II) and Zn(II) and the nature of their bonding are discussed based on analytical, IR, 1H-NMR and mass spectral data.

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