Total Biosynthesis of the Tubulin-Binding Alkaloid Colchicine

2021 ◽  
Author(s):  
Ryan S. Nett ◽  
Elizabeth S. Sattely
Keyword(s):  
Tubulin Binding

scholarly journals Synthesis and Biological Evaluation of α-Tubulin-Binding Pironetin Analogues with Enhanced Lipophilicity

2013 ◽  
Vol 2013 (6) ◽  
pp. 1116-1123 ◽  
Author(s):  
Miguel Carda ◽  
Juan Murga ◽  
Santiago Díaz-Oltra ◽  
Jorge García-Pla ◽  
Julián Paños ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Tubulin Binding ◽  
Synthesis And Biological Evaluation

Crystal structure of tubulin folding cofactor A from Arabidopsis thaliana and its β-tubulin binding characterization

FEBS Letters ◽  
2010 ◽  
Vol 584 (16) ◽  
pp. 3533-3539 ◽  
Author(s):  
Lu Lu ◽  
Jie Nan ◽  
Wei Mi ◽  
Lan-Fen Li ◽  
Chun-Hong Wei ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Arabidopsis Thaliana ◽  
Tubulin Binding ◽  
Β Tubulin

scholarly journals 08-P013 Mercury (Drosophila Tubulin Binding Cofactor B) controls cell polarity through the stabilisation of the microtubule network

2009 ◽  
Vol 126 ◽  
pp. S147-S148
Author(s):  
Alexandre Baffet ◽  
Beatrice Benoit ◽  
Vanessa Gourhand ◽  
Claire Heichette ◽  
Denis Chretien ◽  
...  
Keyword(s):  
Cell Polarity ◽  
Microtubule Network ◽  
Tubulin Binding

scholarly journals Rigid Analogues of Antimitotic Indolobenzazepinones: New Insights into Tubulin Binding via Molecular Modeling

2011 ◽  
Vol 2 (8) ◽  
pp. 565-570 ◽  
Author(s):  
Valérie Pons ◽  
Stéphane Beaumont ◽  
Marie Elise Tran Huu Dau ◽  
Bogdan I. Iorga ◽  
Robert H. Dodd
Keyword(s):  
Molecular Modeling ◽  
Tubulin Binding

Antitumor Agents. 192. Antitubulin Effect and Cytotoxicity of C(7)-Oxygenated Allocolchicinoids

1999 ◽  
Vol 64 (2) ◽  
pp. 217-228 ◽  
Author(s):  
Jian Guan ◽  
Xiao-Kang Zhu ◽  
Arnold Brossi ◽  
Yoko Tachibana ◽  
Kenneth F. Bastow ◽  
...  
Keyword(s):  
Cell Lines ◽  
Antitumor Agents ◽  
Human Tumor ◽  
Crystallographic Analysis ◽  
Antitumor Activities ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
X Ray ◽  
Tubulin Binding ◽  
Marked Resistance

Two allocolchicinoids 6 and 8, prepared from colchicine, together with allo compounds 9-11, made from 6 by reduction and regiodemethylation, were evaluated for antitubulin and antitumor activities. Structures of 6, 8, and 10 were confirmed by X-ray crystallographic analysis. Compounds 6, 8, and 9 have high tubulin binding affinity and display potent inhibitory activities against tubulin polymerization and solid human tumor cell lines. Particularly, drug-resistant KB cell lines, including KB-7d, KB-VCR, and KB-CPT, do not show marked resistance to these compounds.

ViVACCy—A Drug Schedule Based on G2 Blockade and Prolonged Infusion of Multiple Tubulin-Binding Agents A Pilot Study

Cancer ◽  
1990 ◽  
Vol 66 (3) ◽  
pp. 411-417
Author(s):  
Stanley E. Shackney ◽  
Reginald P. Pugh ◽  
Bernard L. Zidar ◽  
Robert N. Raju ◽  
Sheryl R. Simon ◽  
...  
Keyword(s):  
Pilot Study ◽  
Prolonged Infusion ◽  
Tubulin Binding ◽  
Binding Agents

Synthesis and tubulin binding of novel C-10 analogs of colchicine

1993 ◽  
Vol 36 (6) ◽  
pp. 758-764 ◽  
Author(s):  
Marianne E. Staretz ◽  
Susan Bane Hastie
Keyword(s):  
Tubulin Binding
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