Hispidulin Sensitizes Human Ovarian Cancer Cells to TRAIL-Induced Apoptosis by AMPK Activation Leading to Mcl-1 Block in Translation

2010 ◽  
Vol 58 (18) ◽  
pp. 10020-10026 ◽  
Author(s):  
Jung-Mu Yang ◽  
Chao-Ming Hung ◽  
Chen-Nan Fu ◽  
Jang-Chang Lee ◽  
Chi-Hung Huang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Ampk Activation ◽  
Induced Apoptosis

scholarly journals Isoflavones Isolated from the Seeds of Millettia ferruginea Induced Apoptotic Cell Death in Human Ovarian Cancer Cells

Molecules ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 207 ◽  
Author(s):  
Yi-Yue Wang ◽  
Jun Hyeok Kwak ◽  
Kyung-Tae Lee ◽  
Tsegaye Deyou ◽  
Young Pyo Jang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Millettia Ferruginea ◽  
Induced Apoptosis

The seeds of Millettia ferruginea are used in fishing, pesticides, and folk medicine in Ethiopia. Here, the anti-cancer effects of isoflavones isolated from M. ferruginea were evaluated in human ovarian cancer cells. We found that isoflavone ferrugone and 6,7-dimethoxy-3’,4’-methylenedioxy-8-(3,3-dimethylallyl)isoflavone (DMI) had potent cytotoxic effects on human ovarian cancer cell A2780 and SKOV3. Ferrugone and DMI treatment increased the sub-G1 cell population in a dose-dependent manner in A2780 cells. The cytotoxic activity of ferrugone and DMI was associated with the induction of apoptosis, as shown by an increase in annexin V-positive cells. Z-VAD-fmk, a broad-spectrum caspase inhibitor, and z-DEVD-fmk, a caspase-3 inhibitor, significantly reversed both the ferrugone and DMI-induced apoptosis, suggesting that cell death stimulated by the isoflavones is mediated by caspase-3-dependent apoptosis. Additionally, ferrugone-induced apoptosis was found to be caspase-8-dependent, while DMI-induced apoptosis was caspase-9-dependent. Notably, DMI, but not ferrugone, increased the intracellular levels of reactive oxygen species (ROS), and antioxidant N-acetyl-L-cysteine (NAC) attenuated the pro-apoptotic activity of DMI. These data suggest that DMI induced apoptotic cell death through the intrinsic pathway via ROS production, while ferrugone stimulated the extrinsic pathway in human ovarian cancer cells.

scholarly journals shRNA Depletion of cIAP1 Sensitizes Human Ovarian Cancer Cells to Anticancer Agent-Induced Apoptosis

2015 ◽  
Vol 22 (3) ◽  
pp. 167-176 ◽  
Author(s):  
Hong Jin ◽  
You-Yuan Dong ◽  
Hong Zhang ◽  
Ying Cui ◽  
Kai Xie ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Anticancer Agent ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Induced Apoptosis

scholarly journals CURCUMIN INDUCED APOPTOSIS VIA G2/M ARREST IN HUMAN OVARIAN CANCER CELLS.

2016 ◽  
Vol 4 (10) ◽  
pp. 1254-1257
Author(s):  
Jihye Kim. ◽  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Induced Apoptosis

Abstract 973: Salinomycin sensitized paclitaxel-resistant human ovarian cancer cells and induced apoptosis.

2013 ◽  
Author(s):  
Chi-Heum Cho ◽  
Hyun-Gyo Lee ◽  
Bidur Parajuli ◽  
So-Jin Shin ◽  
Sang-Hoon Kwon ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Induced Apoptosis

Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner

2006 ◽  
Vol 102 (2) ◽  
pp. 348-355 ◽  
Author(s):  
Xiaojuan Yan ◽  
Michael Fraser ◽  
Qing Qiu ◽  
Benjamin K. Tsang
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Dependent Manner ◽  
Over Expression ◽  
Induced Apoptosis

scholarly journals Enhancement of cisplatin-induced apoptosis by β-elemene in resistant human ovarian cancer cells

2013 ◽  
Vol 30 (1) ◽  
Author(s):  
Qingdi Quentin Li ◽  
Rebecca X. Lee ◽  
Huasheng Liang ◽  
Yuhua Zhong ◽  
Eddie Reed
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Induced Apoptosis

Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells

2003 ◽  
Vol 89 (1) ◽  
pp. 37-47 ◽  
Author(s):  
David Griffin ◽  
Sylvie Wittmann ◽  
Fei Guo ◽  
Ramadevi Nimmanapalli ◽  
Purva Bali ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Epothilone B ◽  
Molecular Determinants ◽  
Induced Apoptosis
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