Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family

Growth Factor Receptor ◽

Kinase Family ◽

Orally Active ◽

Receptor Tyrosine Kinase Family

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm980398y ◽

1998 ◽

Vol 41 (22) ◽

pp. 4365-4377 ◽

Cited By ~ 55

Author(s):

Diane H. Boschelli ◽

Zhipei Wu ◽

Sylvester R. Klutchko ◽

H. D. Hollis Showalter ◽

James M. Hamby ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Inhibitory Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Tyrosine Kinase Inhibitors

Kinase Inhibitory Activity ◽

ChemInform Abstract: Tyrphostins. Part 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins.

ChemInform ◽

10.1002/chin.199637219 ◽

2010 ◽

Vol 27 (37) ◽

pp. no-no

Author(s):

A. GAZIT ◽

H. APP ◽

G. MCMAHON ◽

J. CHEN ◽

A. LEVITZKI ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Growth Factor Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Kinase Structure

Inhibitors of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Cardiovascular Drug Reviews ◽

10.1111/j.1527-3466.1996.tb00320.x ◽

1996 ◽

Vol 14 (4) ◽

pp. 380-399 ◽

Cited By ~ 4

Author(s):

Glenda E. Bilder ◽

Camilo J. Rojas

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor

Platelet-Derived Growth Factor Receptor-Tyrosine Kinase Inhibitor, Imatinib, Is Effective for Treating Pulmonary Hypertension Induced by Pulmonary Tumor Thrombotic Microangiopathy

International Heart Journal ◽

10.1536/ihj.14-220 ◽

2015 ◽

Vol 56 (2) ◽

pp. 245-248 ◽

Cited By ~ 23

Author(s):

Shun Minatsuki ◽

Ichiro Miura ◽

Atsushi Yao ◽

Hiroyuki Abe ◽

Hironori Muraoka ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Thrombotic Microangiopathy ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Pulmonary Tumor

Novel Bis(1H-indol-2-yl)methanones as Potent Inhibitors of FLT3 and Platelet-Derived Growth Factor Receptor Tyrosine Kinase

Journal of Medicinal Chemistry ◽

10.1021/jm058033i ◽

2006 ◽

Vol 49 (11) ◽

pp. 3101-3115 ◽

Cited By ~ 37

Author(s):

Siavosh Mahboobi ◽

Andrea Uecker ◽

Andreas Sellmer ◽

Christophe Cénac ◽

Heymo Höcher ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor

Inhibition of platelet-derived growth factor receptor tyrosine kinase and downstream signaling pathways by Compound C

Cellular Signalling ◽

10.1016/j.cellsig.2012.12.016 ◽

2013 ◽

Vol 25 (4) ◽

pp. 883-897 ◽

Cited By ~ 8

Author(s):

Hyun Jin Kwon ◽

Go-Eun Kim ◽

Yun Taek Lee ◽

Meong-Sook Jeong ◽

Insug Kang ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Signaling Pathways ◽

Growth Factor Receptor ◽

Downstream Signaling ◽

Compound C

Studies leading to the identification of ZD1839 (iressa™): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)00344-4 ◽

2001 ◽

Vol 11 (14) ◽

pp. 1911-1914 ◽

Cited By ~ 371

Author(s):

Andrew J Barker ◽

Keith H Gibson ◽

Walter Grundy ◽

Andrew A Godfrey ◽

Jeffrey J Barlow ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Orally Active

Inhibition of platelet‐derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation

The FASEB Journal ◽

10.1096/fasebj.11.13.9367346 ◽

1997 ◽

Vol 11 (13) ◽

pp. 1119-1126 ◽

Cited By ~ 94

Author(s):

Marukka Myllärniemi ◽

Lazaro Calderon ◽

Karl Lemström ◽

Elisabeth Buchdunger ◽

Pekka Häyry

Keyword(s):

Smooth Muscle ◽

Cell Migration ◽

Growth Factor ◽

Tyrosine Kinase ◽

Smooth Muscle Cell ◽

Growth Factor Receptor ◽

Smooth Muscle Cell Migration ◽

Cell Migration And Proliferation

Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase

Cancer Science ◽

10.1111/cas.12101 ◽

2013 ◽

Vol 104 (4) ◽

pp. 486-494 ◽

Cited By ~ 9

Author(s):

Yoshiko Awazu ◽

Akio Mizutani ◽

Yoshinori Nagase ◽

Shuntarou Tsuchiya ◽

Kazuhide Nakamura ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Growth Factor Receptor ◽

Selective Inhibitor ◽

Vascular Endothelial ◽

Endothelial Growth Factor

N-GLUCURONIDATION OF THE PLATELET-DERIVED GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR 6,7-(DIMETHOXY-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)-(3-FLUORO-PHENYL)-AMINE BY HUMAN UDP-GLUCURONOSYLTRANSFERASES

Drug Metabolism and Disposition ◽

10.1124/dmd.106.009274 ◽

2006 ◽

Vol 34 (5) ◽

pp. 748-755 ◽

Cited By ~ 25

Author(s):

Z. Yan ◽

G. W. Caldwell ◽

D. Gauthier ◽

G. C. Leo ◽

J. Mei ◽

...

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Growth Factor Receptor ◽

Receptor Tyrosine Kinase Inhibitor