Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic Derivatives of Chromen-4-one in Human Cancer Cells

2006 ◽  
Vol 49 (13) ◽  
pp. 3800-3808 ◽  
Author(s):  
Vivek Barve ◽  
Fakhara Ahmed ◽  
Shreelekha Adsule ◽  
Sanjeev Banerjee ◽  
Sudhir Kulkarni ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cancer Cells ◽  
Molecular Characterization ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Synthetic Derivatives ◽  
Derivatives Of

Water soluble derivatives of platinum carbonyl Chini clusters: synthesis, molecular structures and cytotoxicity of [Pt12(CO)20(PTA)4]2− and [Pt15(CO)25(PTA)5]2−

2018 ◽  
Vol 47 (13) ◽  
pp. 4467-4477 ◽  
Author(s):  
Lucinda K. Batchelor ◽  
Beatrice Berti ◽  
Cristiana Cesari ◽  
Iacopo Ciabatti ◽  
Paul J. Dyson ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Molecular Structures ◽  
Water Soluble ◽  
Human Cancer Cells ◽  
Derivatives Of

The cytotoxicity towards human cancer cells of water soluble Chini clusters is reported.

Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells

2006 ◽  
Vol 14 (3) ◽  
pp. 875-884 ◽  
Author(s):  
Karel Doležal ◽  
Igor Popa ◽  
Vladimír Kryštof ◽  
Lukáš Spíchal ◽  
Martina Fojtíková ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells

Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin

2013 ◽  
Vol 64 ◽  
pp. 621-628 ◽  
Author(s):  
Jian-Fei Liu ◽  
Chun-Yan Sang ◽  
Xiao-Hui Xu ◽  
Lin-Lin Zhang ◽  
Xuan Yang ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Derivatives Of

scholarly journals Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells

2012 ◽  
Vol 116 ◽  
pp. 180-187 ◽  
Author(s):  
Gerhard Mühlgassner ◽  
Caroline Bartel ◽  
Wolfgang F. Schmid ◽  
Michael A. Jakupec ◽  
Vladimir B. Arion ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Arene Complexes ◽  
Human Cancer Cells

Synthesis and evaluation of apoptotic induction of human cancer cells by ester derivatives of thujone

2019 ◽  
Vol 29 (2) ◽  
pp. 268-280
Author(s):  
Emily Castner ◽  
Matthew Dickson ◽  
Anna Mykytyn ◽  
Navindra P. Seeram ◽  
Geneive E. Henry ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Derivatives Of ◽  
Apoptotic Induction

scholarly journals Synthesis and anticancer activity of 5-sulfonyl derivatives of 1,3-oxazole-4-carboxylates

2020 ◽  
Vol 15 (2) ◽  
pp. 13-21
Author(s):  
Stepan Pilyo ◽  
Оlexandr Kozachenko ◽  
Victor Zhirnov ◽  
Maryna Kachaeva ◽  
Oleksandr Kobzar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Docking ◽  
Complex Formation ◽  
Cancer Cells ◽  
Cell Lines ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Screening Protocol ◽  
Derivatives Of

A series of new 2-aryl 5-sulfonyl-1,3-oxazole-4-carboxylates for NCI anticancer screening protocol against 60 cancer cell lines were synthesized. Screening was performed in vitro on 60 cell lines of lungs, kidneys, CNS, ovaries, prostate, and breast cancer, leukemia, and melanoma. Methyl 5-benzylsulfonyl-2-phenyl-1,3-oxazole-4-carboxylate 15 exhibited potent and broad range of cytotoxic activity against tested human cancer cells with average GI50, TGI, and LC50 values of 5.37·10-6, 1.29·10-5 and 3.6·10-5 mol/L respectively. Molecular docking was used to evaluate the possible interaction of compound 15 with tubulin as well as a complex formation with CDK2.

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