Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)

Small Molecule Antagonist ◽

Structure Activity ◽

Leukocyte Function

Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02191 ◽

2021 ◽

Vol 64 (6) ◽

pp. 3299-3319

Author(s):

Jean-Olivier Zirimwabagabo ◽

Ameera B. A. Jailani ◽

Paris Avgoustou ◽

Matthew J. Tozer ◽

Karl R. Gibson ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Antagonist ◽

Receptor Structure ◽

Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure–activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.02.014 ◽

2016 ◽

Vol 114 ◽

pp. 345-364 ◽

Cited By ~ 4

Author(s):

Shigeo Hayashi ◽

Katsuyo Ohashi ◽

Sachiko Mihara ◽

Eriko Nakata ◽

Chie Emoto ◽

...

Keyword(s):

Small Molecule ◽

Orphanin Fq ◽

Design Synthesis ◽

Synthesis and structure–activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

10.1016/j.bmcl.2007.01.104 ◽

2007 ◽

Vol 17 (8) ◽

pp. 2171-2178 ◽

Cited By ~ 8

Author(s):

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Junko Tamiya ◽

Mingzhu Zhang ◽

Brian Dyck ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity ◽

Melanin Concentrating Hormone

Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

10.1016/j.bmcl.2006.06.049 ◽

2006 ◽

Vol 16 (18) ◽

pp. 4922-4930 ◽

Cited By ~ 10

Author(s):

Sarah Hudson ◽

Mehrak Kiankarimi ◽

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Dongpei Wu ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity ◽

Melanin Concentrating Hormone

A Comprehensive Overview of Structure‐Activity Relationships of Small‐Molecule Splicing Modulators Targeting SF3B1 as Anticancer Agents

ChemMedChem ◽

10.1002/cmdc.202000642 ◽

2020 ◽

Vol 15 (22) ◽

pp. 2098-2120

Author(s):

Datong Zhang ◽

Fancui Meng

Keyword(s):

Small Molecule ◽

Anticancer Agents ◽

Comprehensive Overview ◽

Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure–activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

10.1016/j.bmcl.2009.02.043 ◽

2009 ◽

Vol 19 (7) ◽

pp. 1986-1990 ◽

Cited By ~ 9

Author(s):

Diane B. Hauze ◽

Murty V. Chengalvala ◽

Joshua E. Cottom ◽

Irene B. Feingold ◽

Lloyd Garrick ◽

...

Keyword(s):

Small Molecule ◽

Gnrh Receptor ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Receptor Structure ◽

Small Molecule Inhibitors of KDR (VEGFR-2) Kinase: An Overview of Structure Activity Relationships

Current Topics in Medicinal Chemistry ◽

10.2174/1568026023393273 ◽

2002 ◽

Vol 2 (9) ◽

pp. 973-1000 ◽

Cited By ~ 63

Author(s):

Stephen Boyer

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Small-molecule glucosylation by sucrose phosphorylase: structure–activity relationships for acceptor substrates revisited

Carbohydrate Research ◽

10.1016/j.carres.2010.03.035 ◽

2010 ◽

Vol 345 (10) ◽

pp. 1492-1496 ◽

Cited By ~ 14

Author(s):

Christiane Luley-Goedl ◽

Bernd Nidetzky

Keyword(s):

Small Molecule ◽

Sucrose Phosphorylase ◽

Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1

10.1016/j.bmcl.2006.06.045 ◽

2006 ◽

Vol 16 (17) ◽

pp. 4450-4457 ◽

Cited By ~ 6

Author(s):

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Brian Dyck ◽

Jonathan Grey ◽

Junko Tamiya ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity ◽

Melanin Concentrating Hormone

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N′-arylpiperazine Series

Journal of Medicinal Chemistry ◽

10.1021/jm5000497 ◽

2014 ◽

Vol 57 (7) ◽

pp. 3094-3116 ◽

Cited By ~ 37

Author(s):

Nobuko Nishimura ◽

Mark H. Norman ◽

Longbin Liu ◽

Kevin C. Yang ◽

Kate S. Ashton ◽

...

Keyword(s):

Small Molecule ◽

Protein Interaction ◽

Regulatory Protein ◽

Glucokinase Regulatory Protein ◽