Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives

Design And Synthesis ◽

Inactivation Mechanism of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid: Chemical Conversion of the Inactivator in the Active Site

Inorganic Chemistry ◽

10.1021/acs.inorgchem.1c00046 ◽

2021 ◽

Author(s):

Lijuan Yan ◽

Yijing Wang ◽

Shiqing Zhang ◽

Xinyi Li ◽

Jingjing Wei ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Active Site ◽

Chemical Conversion ◽

Pentanoic Acid ◽

Inactivation Mechanism ◽

New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.06.025 ◽

2012 ◽

Vol 20 (17) ◽

pp. 5296-5304 ◽

Cited By ~ 9

Author(s):

Elodie Lohou ◽

Jana Sopkova-de Oliveira Santos ◽

Pascale Schumann-Bard ◽

Michel Boulouard ◽

Silvia Stiebing ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Active Site ◽

Binding Mode ◽

Design and Synthesis of C5 Methylatedl-Arginine Analogues as Active Site Probes for Nitric Oxide Synthase

Journal of the American Chemical Society ◽

10.1021/ja0746159 ◽

2007 ◽

Vol 129 (41) ◽

pp. 12563-12570 ◽

Cited By ~ 21

Author(s):

Nathaniel I. Martin ◽

Joshua J. Woodward ◽

Michael B. Winter ◽

William T. Beeson ◽

Michael A. Marletta

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Active Site ◽

Design And Synthesis ◽

Structure-Based Design and Synthesis ofNω-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water

Journal of Medicinal Chemistry ◽

10.1021/jm061305c ◽

2007 ◽

Vol 50 (9) ◽

pp. 2089-2099 ◽

Cited By ~ 22

Author(s):

Jiwon Seo ◽

Jotato Igarashi ◽

Huiying Li ◽

Pavel Martásek ◽

Linda J. Roman ◽

...

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Selective Inhibitors ◽

Structural Water ◽

Design And Synthesis ◽

Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure

Brain Research ◽

10.1016/s0006-8993(96)00620-8 ◽

1996 ◽

Vol 734 (1-2) ◽

pp. 109-115 ◽

Cited By ~ 76

Author(s):

K Patel

Keyword(s):

Gene Expression ◽

Nitric Oxide ◽

Heart Failure ◽

Nitric Oxide Synthase ◽

Role of neuronal nitric oxide synthase in gastric hypermotility induced by intracisternal TRH analog, RX 77368, in anesthetized rats

Gastroenterology ◽

10.1016/s0016-5085(01)82651-2 ◽

2001 ◽

Vol 120 (5) ◽

pp. A533-A534

Author(s):

K KANAMOTO ◽

K KAWAKUBO ◽

D ADELSON ◽

Y TACHE

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Anesthetized Rats ◽

Optical density analysis of levels of neuronal nitric oxide synthase (nNOS), substance P (SP) and catechoalmines in myenteric ganglia of lleum, proximal colon (PC) and distal colon (DC) from vehicle-and streptozotocin (STZ)-treated guinea pigs

Gastroenterology ◽

10.1016/s0016-5085(01)81666-8 ◽

2001 ◽

Vol 120 (5) ◽

pp. A335-A335

Author(s):

K LEPARD ◽

R PORTER

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Substance P ◽

Guinea Pigs ◽

Distal Colon ◽

Proximal Colon ◽

Density Analysis ◽

Oxide Synthase ◽

Myenteric Ganglia

Colocalization of neuronal nitric oxide synthase and calretinin in the mouse hippocampus: quantitative and morphometric analysis with optical disector

Neuroscience Research ◽

10.1016/s0168-0102(00)81186-4 ◽

2000 ◽

Vol 38 ◽

pp. S57

Author(s):

S Jinno

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Morphometric Analysis ◽

Optical Disector ◽

Mouse Hippocampus ◽

Effects of endothelial and neuronal nitric oxide synthase inhibitors on release of amino acids from hippocampus after transient forebrain ischemia

Neuroscience Research ◽

10.1016/s0168-0102(00)81713-7 ◽

2000 ◽

Vol 38 ◽

pp. S144

Author(s):

M Jiang

Keyword(s):

Nitric Oxide ◽

Amino Acids ◽

Nitric Oxide Synthase ◽

Forebrain Ischemia ◽

Nitric Oxide Synthase Inhibitors ◽

Transient Forebrain Ischemia ◽

Faculty Opinions recommendation of Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1031032.363473 ◽

2006 ◽

Author(s):

Henry Lin

Keyword(s):

Nitric Oxide ◽

Stem Cell ◽

Nitric Oxide Synthase ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Neural Stem Cell ◽

Gastric Function ◽

Oxide Synthase ◽

Deficient Mice