Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists

2012 ◽  
Vol 55 (4) ◽  
pp. 1538-1552 ◽  
Author(s):  
Nobuyuki Negoro ◽  
Shinobu Sasaki ◽  
Masahiro Ito ◽  
Shuji Kitamura ◽  
Yoshiyuki Tsujihata ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Pharmacokinetic Profiles ◽  
Alkanoic Acids ◽  
Fused Ring ◽  
Free Fatty Acid Receptor ◽  
G Protein Coupled

scholarly journals The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation

2013 ◽  
Vol 288 (9) ◽  
pp. 6542-6551 ◽  
Author(s):  
Fabien Wauquier ◽  
Claire Philippe ◽  
Laurent Léotoing ◽  
Sylvie Mercier ◽  
Marie-Jeanne Davicco ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Bone Loss ◽  
G Protein ◽  
Osteoclast Differentiation ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Free Fatty Acid Receptor ◽  
G Protein Coupled ◽  
Fatty Acid Receptor

scholarly journals Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein–Coupled Receptor 120

2016 ◽  
Vol 89 (5) ◽  
pp. 505-520 ◽  
Author(s):  
Rudi Prihandoko ◽  
Elisa Alvarez-Curto ◽  
Brian D. Hudson ◽  
Adrian J. Butcher ◽  
Trond Ulven ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Acid Receptor ◽  
Free Fatty Acid Receptor ◽  
G Protein Coupled ◽  
Fatty Acid Receptor

Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells

2015 ◽  
Vol 55 (11) ◽  
pp. 1553-1559 ◽  
Author(s):  
Shuhei Ishii ◽  
Yuka Kitamura ◽  
Miku Hirane ◽  
Ayaka Tomimatsu ◽  
Kaori Fukushima ◽  
...  
Keyword(s):  
Cell Migration ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
G Protein ◽  
Migration And Invasion ◽  
Negative Effects ◽  
Acid Receptor ◽  
Ht1080 Cells ◽  
Free Fatty Acid Receptor ◽  
G Protein Coupled
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