Computational Investigation of Drug-Resistant Mutant of M2 Proton Channel (S31N) Against Rimantadine

2014 ◽  
Vol 70 (2) ◽  
pp. 975-982 ◽  
Author(s):  
V. Karthick ◽  
K. Ramanathan
Keyword(s):  
Resistant Mutant ◽  
Proton Channel ◽  
Drug Resistant ◽  
Computational Investigation ◽  
Drug Resistant Mutant ◽  
M2 Proton Channel

scholarly journals Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130022 ◽  
Author(s):  
Satoshi Yoshimi ◽  
Hidenori Ochi ◽  
Eisuke Murakami ◽  
Takuro Uchida ◽  
Hiromi Kan ◽  
...  
Keyword(s):  
Resistant Mutant ◽  
Drug Resistant ◽  
Accurate Evaluation ◽  
Genotype 1B ◽  
Invader Assay ◽  
Drug Resistant Mutant ◽  
Strain Frequency

scholarly journals Baloxavir Marboxil Treatment of Nude Mice Infected With Influenza A Virus

2019 ◽  
Vol 221 (10) ◽  
pp. 1699-1702 ◽  
Author(s):  
Maki Kiso ◽  
Seiya Yamayoshi ◽  
Jurika Murakami ◽  
Yoshihiro Kawaoka
Keyword(s):  
Nude Mice ◽  
Influenza A ◽  
Body Weight Loss ◽  
Resistant Mutant ◽  
Prolonged Treatment ◽  
Drug Resistant ◽  
Neuraminidase Inhibitors ◽  
Drug Resistant Mutant ◽  
Suboptimal Dose ◽  
Resistant Mutants

Abstract Background Immunocompromised patients infected with influenza virus require prolonged treatment with neuraminidase inhibitors, because these patients are not able to eradicate the virus from the respiratory tract, leading to the emergence of drug-resistant mutant viruses. Methods In this study, we examined the efficacy of baloxavir marboxil in nude mice that were immunologically deficient. Results Daily treatment with a suboptimal dose of baloxavir marboxil increased the survival time of the virus-infected nude mice but did not clear the virus from their respiratory organs, resulting in gradual body weight loss after termination of treatment. Conclusions Despite the prolonged baloxavir marboxil treatment, few resistant mutants were detected.

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