Design, Synthesis, and Biological Evaluation of Novel 3-Aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as Vascular Endothelial Growth Factor Receptor (VEGF-R) Inhibitors

2008 ◽  
Vol 51 (13) ◽  
pp. 3814-3824 ◽  
Author(s):  
Christian Peifer ◽  
Roland Selig ◽  
Katrin Kinkel ◽  
Dimitri Ott ◽  
Frank Totzke ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Biological Evaluation ◽  
Vascular Endothelial ◽  
Design Synthesis ◽  
Endothelial Growth Factor ◽  
Synthesis And Biological Evaluation

Design, Synthesis, and Evaluation of Original Carriers for Targeting Vascular Endothelial Growth Factor Receptor Interactions

2005 ◽  
Vol 22 (8) ◽  
pp. 1411-1421 ◽  
Author(s):  
Mario Gonçalves ◽  
Karine Estieu-Gionnet ◽  
Thomas Berthelot ◽  
Georges Laïn ◽  
Mireille Bayle ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Design Synthesis ◽  
Receptor Interactions ◽  
Endothelial Growth Factor

scholarly journals Discovery of novel picolinamide-based derivatives as novel VEGFR-2 kinase inhibitors: synthesis, in vitro biological evaluation and molecular docking

MedChemComm ◽  
2018 ◽  
Vol 9 (6) ◽  
pp. 1054-1058
Author(s):  
Wuji Sun ◽  
Shubiao Fang ◽  
Hong Yan
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Molecular Docking ◽  
Growth Factor ◽  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Growth Factor Receptor ◽  
Biological Evaluation ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has emerged as an attractive target for cancer therapy.

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