Medetomidine Analogs as α2-Adrenergic Ligands. 3. Synthesis and Biological Evaluation of a New Series of Medetomidine Analogs and Their Potential Binding Interactions with α2-Adrenoceptors Involving a “Methyl Pocket”

Xiaoyan Zhang; Joseph E. De Los Angeles; Mei-Ying He; James T. Dalton; Gamal Shams; Longping Lei; Popat N. Patil; Dennis R. Feller; Duane D. Miller; Fu-Lian Hsu

doi:10.1021/jm960642q

Medetomidine Analogs as α2-Adrenergic Ligands. 3. Synthesis and Biological Evaluation of a New Series of Medetomidine Analogs and Their Potential Binding Interactions with α2-Adrenoceptors Involving a “Methyl Pocket”

Journal of Medicinal Chemistry ◽

10.1021/jm960642q ◽

1997 ◽

Vol 40 (19) ◽

pp. 3014-3024 ◽

Cited By ~ 14

Author(s):

Xiaoyan Zhang ◽

Joseph E. De Los Angeles ◽

Mei-Ying He ◽

James T. Dalton ◽

Gamal Shams ◽

...

Keyword(s):

Biological Evaluation ◽

Binding Interactions ◽

Α2 Adrenoceptors ◽

Potential Binding ◽

Synthesis And Biological Evaluation

ChemInform Abstract: Medetomidine Analogues as α2-Adrenergic Ligands. Part 3. Synthesis and Biological Evaluation of a New Series of Medetomidine Analogues and Their Potential Binding Interactions with α2- Adrenoceptors Involving a “Methyl Pocket”.

ChemInform ◽

10.1002/chin.199752148 ◽

2010 ◽

Vol 28 (52) ◽

pp. no-no

Author(s):

X. ZHANG ◽

J. E. DE LOS ANGELES ◽

M.-Y. HE ◽

J. T. DALTON ◽

G. SHAMS ◽

...

Keyword(s):

Biological Evaluation ◽

Binding Interactions ◽

Α2 Adrenoceptors ◽

Potential Binding ◽

Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of New Salvinorin B-Sulfonate Ester Ligands to Opioid Receptors

Planta Medica ◽

10.1055/s-0033-1336486 ◽

2013 ◽

Vol 79 (05) ◽

Author(s):

PR Polepally ◽

BL Roth ◽

K White ◽

E Vardy ◽

JK Zjawiony

Keyword(s):

Opioid Receptors ◽

Biological Evaluation ◽

Sulfonate Ester ◽

Synthesis And Biological Evaluation

Total synthesis and biological evaluation of Lyngbyastatin 7 for the treatment of pulmonary diseases

Planta Medica ◽

10.1055/s-0035-1556358 ◽

2015 ◽

Vol 81 (11) ◽

Author(s):

D Luo ◽

QY Chen ◽

H Luesch

Keyword(s):

Total Synthesis ◽

Biological Evaluation ◽

Pulmonary Diseases ◽

Synthesis And Biological Evaluation

Harnessing the main event of drimentines biosynthesis: bio-inspired synthesis and biological evaluation of Δ8'-isodrimentine A and related compounds

Planta Medica ◽

10.1055/s-0036-1596745 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381

Author(s):

A Skiredj ◽

MA Beniddir ◽

L Evanno ◽

E Poupon

Keyword(s):

Biological Evaluation ◽

Synthesis And Biological Evaluation ◽

Related Compounds

Design, Synthesis and Biological Evaluation of some Chalcone Derivatives as Potential Pancreatic Lipase Inhibitors

10.3390/ecsoc-17-b024 ◽

2013 ◽

Author(s):

Dao Tran

Keyword(s):

Pancreatic Lipase ◽

Biological Evaluation ◽

Design Synthesis ◽

Chalcone Derivatives ◽

Pancreatic Lipase Inhibitors ◽

Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of Metal Complexes

Asian journal of biochemical and pharmaceutical research ◽

10.24214/ajbpr/8/2/0107 ◽

2018 ◽

Vol 8 (2) ◽

Keyword(s):

Metal Complexes ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

10.26434/chemrxiv.6103607.v1 ◽

2018 ◽

Author(s):

Jonathan J. Mills ◽

Kaylib R. Robinson ◽

Troy E. Zehnder ◽

Joshua G. Pierce

Keyword(s):

Natural Products ◽

Natural Product ◽

Mechanism Of Action ◽

Marine Natural Products ◽

Biological Evaluation ◽

Lead Compounds ◽

Follow Up Studies ◽

Initial Resistance ◽

Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Synthesis and biological evaluation of Schiff bases and pyrazole derivatives derive from chalcones, (2E)1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.12.01.138 ◽

2020 ◽

Vol 12 (1) ◽

Keyword(s):

Schiff Bases ◽

Biological Evaluation ◽

Pyrazole Derivatives ◽

Synthesis And Biological Evaluation

Faculty Opinions recommendation of Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1064759.517678 ◽

2007 ◽

Author(s):

Hugh Rosen

Keyword(s):

Biological Evaluation ◽

Receptor Agonists ◽

Sphingosine 1 Phosphate ◽

Subtype Selective ◽

Synthesis And Biological Evaluation ◽

Receptor Agonists And Antagonists

Faculty Opinions recommendation of Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726271231.793520213 ◽

2016 ◽

Author(s):

Miles Congreve ◽

Mark Pickworth

Keyword(s):

G Protein ◽

Biological Evaluation ◽

Receptor Kinase ◽

G Protein Coupled Receptor ◽

Design Synthesis ◽

G Protein Coupled ◽

Synthesis And Biological Evaluation