Reactions in the solid state. 2. The crystal structures of the inclusion complexes of 1,1,6,6-tetraphenylhexa-2,4-diyne-1,6-diol with benzylideneacetophenone and 2,5-diphenylhydroquinone with dibenzylideneacetone

Essential oils are widely recognized as natural alternatives to pharmaceutical antibacterial and antifungal agents. With respect to standard pharmaceutics, the advantages of essential oils are their (i) low production costs, (ii) lack of chemical and biochemical drawbacks that are intrinsic to the synthetic production process and (iii) good tolerance by humans. On the other hand, the liquid nature of essential oils poses concerns about their actual application in different therapeutic issues regarding their persistence and the ability to control or prolong drug release. In this study, two essential oils from oregano and winter savory showing antibacterial and antifungal features were complexed in a solid state with beta-cyclodextrin. Host–guest inclusion complexes were characterized using FT-IR spectroscopy, ESI-MS and GC-MS techniques. Manyfold terpenic and non-terpenic components of the oils could be observed and unambiguously identified as being included inside the carbohydrate hosts. Many of them provided a specific biocidal action. Indeed, essential oil host–guest inclusion products were tested against two Candida species and an S. aureus reference strain, showing that the oils effectively maintained their liquid performances. Solid-state tablets of the essential oil inclusion complexes embedded in polyvinylpyrrolidone could be obtained. These results pave the way for the solid-state application of essential oils in antibacterial and antifungal pharmaceutical treatments.

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Functionalised Terpyridines and Their Metal Complexes—Solid-State Interactions

Chemistry ◽

10.3390/chemistry3010016 ◽

2021 ◽

Vol 3 (1) ◽

pp. 199-227

Author(s):

Young Hoon Lee ◽

Jee Young Kim ◽

Sotaro Kusumoto ◽

Hitomi Ohmagari ◽

Miki Hasegawa ◽

...

Keyword(s):

Solid State ◽

Metal Complexes ◽

Crystal Structures ◽

Weak Interactions ◽

Dispersion Interactions ◽

Derivatives Of

Analysis of the weak interactions within the crystal structures of 33 complexes of various 4′-aromatic derivatives of 2,2′:6′,2″-terpyridine (tpy) shows that interactions that exceed dispersion are dominated, as expected, by cation⋯anion contacts but are associated with both ligand–ligand and ligand–solvent contacts, sometimes multicentred, in generally complicated arrays, probably largely determined by dispersion interactions between stacked aromatic units. With V(V) as the coordinating cation, there is evidence that the polarisation of the ligand results in an interaction exceeding dispersion at a carbon bound to nitrogen with oxygen or fluorine, an interaction unseen in the structures of M(II) (M = Fe, Co, Ni, Cu, Zn, Ru and Cd) complexes, except when 1,2,3-trimethoxyphenyl substituents are present in the 4′-tpy.

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Bis(1-phenyl-1-propyne) complexes of tungsten(II): crystal structures of [WI2(CO)(NCR)(η2-MeC2Ph)2] (R = Me, Et, or Ph)

Canadian Journal of Chemistry ◽

10.1139/v01-028 ◽

2001 ◽

Vol 79 (3) ◽

pp. 263-271

Author(s):

Paul K Baker ◽

Michael GB Drew ◽

Deborah S Evans

Keyword(s):

Carbon Monoxide ◽

Solid State ◽

Crystal Structures ◽

Octahedral Geometry ◽

X Ray ◽

X Ray Crystallography ◽

Alkyne Complexes ◽

First Time

Reaction of [WI2(CO)3(NCMe)2] with two equivalents of 1-phenyl-1-propyne (MeC2Ph) in CH2Cl2, and in the absence of light, gave the bis(1-phenyl-1-propyne) complex [WI2(CO)(NCMe)(η2-MeC2Ph)2] (1) in 77% yield. Treatment of equimolar quantities of 1 and NCR (R = Et, i-Pr, t-Bu, Ph) in CH2Cl2 afforded the nitrile-exchanged products, [WI2(CO)(NCR)(η2-MeC2Ph)2] (2-5) (R = Et (2), i-Pr (3), t-Bu (4), Ph (5)). Complexes 1, 2, and 5 were structurally characterized by X-ray crystallography. All three structures have the same pseudo-octahedral geometry, with the equatorial sites being occupied by cis and parallel alkyne groups, which are trans to the cis-iodo groups. The trans carbon monoxide and acetonitrile ligands occupy the axial sites. In structures 1 and 2, the methyl and phenyl substituents of the 1-phenyl-1-propyne ligands are cis to each other, whereas for the bulkier NCPh complex (5), the methyl and phenyl groups are trans to one another. This is the first time that this arrangement has been observed in the solid state in bis(alkyne) complexes of this type.Key words: bis(1-phenyl-1-propyne), carbonyl, nitrile, diiodo, tungsten(II), crystal structures.

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Inclusion complexes of the natural product gossypol. Crystal structures of gossypol complexes with benzene and chloroform as guests

Journal of Inclusion Phenomena and Macrocyclic Chemistry ◽

10.1007/bf01053121 ◽

1990 ◽

Vol 9 (3) ◽

pp. 231-242 ◽

Cited By ~ 13

Author(s):

M. Gdaniec ◽

B. T. Ibragimov ◽

S. A. Talipov

Keyword(s):

Natural Product ◽

Crystal Structures ◽

Inclusion Complexes

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NOTIZEN. Weitere Verbindungen vom Typ A3NO3: K3NO3 und Rb3NO3 / Further Compounds Typ A3NO3: K3NO3 and Rb3NO3

Zeitschrift für Naturforschung B ◽

10.1515/znb-1980-0221 ◽

1980 ◽

Vol 35 (2) ◽

pp. 237-238 ◽

Cited By ~ 5

Author(s):

Martin Jansen

Keyword(s):

Solid State ◽

Crystal Structures ◽

Solid State Reaction ◽

X Ray

Abstract K3NO3 and RbsNO3 were prepared by solid state reaction of equimolar mixtures of K2O/KNO2 and Rb20/RbN02, respectively. According to X-ray powder photographs their crystal structures are derived from the perovs-kite structure. K3NO3 is isostructural with Na3NO3 (a = 521.7 pm, Z = 1), Rb3NO3 represents a tetragonally distorted variant with a = 770.5, c = 550.8 pm and Z = 2.

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