Dehydration of N-(p-Chlorophenyl)phthalamic Acid by Acetic and Trifluoroacetic Anhydrides1

1964 ◽  
Vol 29 (3) ◽  
pp. 745-747 ◽  
Author(s):  
William R. Roderick
Keyword(s):  
Phthalamic Acid

scholarly journals Enhancement of Antibacterial Activity of Paludifilum halophilum and Identification of N-(1-Carboxy-ethyl)-phthalamic Acid as the Main Bioactive Compound

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Donyez Frikha-Dammak ◽  
Jawhar Fakhfakh ◽  
Dalel Belhaj ◽  
Emna Bouattour ◽  
Houda Ayadi ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Large Scale ◽  
Maximum Yield ◽  
Thick Layer ◽  
Bioactive Compound ◽  
Yield Potential ◽  
Metabolite Production ◽  
Phthalamic Acid ◽  
Initial Ph ◽  
Fermentation Parameters

The aim of this study was to determine the combined effect of fermentation parameters and enhance the production of cellular biomass and antibacterial compounds from Paludifilum halophilum SMBg3 using the response surface methodology (RSM). Eight variables were screened to assess the effects of fermentation parameters on growth and metabolite production by Taguchi experimental design. Among these, the initial pH, temperature, and the percentage of MgSO4·7H2O in the medium were found to be most influential. The Box–Behnken design was applied to derive a statistical model for the optimization of these three fermentation parameters. The optimal parameters were initial pH: 8.3, temperature growth: 44°C, and MgSO4·7H2O: 1.6%, respectively. The maximum yield of biomass and metabolite production were, respectively, 11 mg/mL dry weight and 15.5 mm inhibition zone diameter against Salmonella enterica, which were in agreement with predicted values. The bioactive compounds were separated by the thick-layer chromatography technique and analyzed by GC/MS, NMR (1D and 2D), and Fourier-transform infrared spectroscopy (FT-IR). In addition to several fatty acids, N-(1-carboxy-ethyl)-phthalamic acid was identified as the main antibacterial compound. This element exhibited a potent activity against the ciprofloxacin-resistant Salmonella enterica CIP 8039 and Pseudomonas aeruginosa ATCC 9027 with a minimum inhibitory concentration (MIC) value range of 12.5–25 μg/mL. Results demonstrated that P. halophilum strain SMBg3 is a promising resource for novel antibacterial production due to its high-level yield potential and the capacity for large-scale fermentation.

Kinetics and mechanism of alkaline hydrolysis of N-(2-bromoethyl)phthalamic acid

1985 ◽  
Vol 50 (26) ◽  
pp. 5859-5860 ◽  
Author(s):  
M. Niyaz Khan
Keyword(s):  
Alkaline Hydrolysis ◽  
Kinetics And Mechanism ◽  
Phthalamic Acid ◽  
Hydrolysis Of

ChemInform Abstract: Preparation of Phthalamic Acid Derivatives and Ring Closure to Phthalimidobarbituric Acids.

ChemInform ◽  
2008 ◽  
Vol 39 (13) ◽  
Author(s):  
Agnieszka Ambrozak ◽  
Michael Guetschow
Keyword(s):  
Ring Closure ◽  
Phthalamic Acid

Inhibitors of the geotropic response in plants. The crystal structures of 2-[(Naphthalen-2-yl)carbamoyl]benzoic acid (β-Naptalam), 2-(Phenylcarbamoyl)-benzoic acid and 2-(5-Phenyl-1,3,4-oxadiazol-2-yl)benzoic acid

1983 ◽  
Vol 36 (12) ◽  
pp. 2455 ◽  
Author(s):  
G Smith ◽  
CHL Kennard ◽  
GF Katekar
Keyword(s):  
Hydrogen Bonding ◽  
Carboxylic Acid ◽  
Benzoic Acid ◽  
Crystal Structures ◽  
Carboxylic Acids ◽  
Intermolecular Hydrogen Bonding ◽  
X Ray Diffraction ◽  
X Ray ◽  
Carboxylic Acid Groups ◽  
Phthalamic Acid

The crystal structures of three geotropically active phthalamic acid derivatives have been determined by means of X-ray diffraction and the structural systematics for the series compared. The three acids are conformationally similar and, in contrast to the tendency among carboxylic acids to form hydrogen-bonded dimers, they exist as monomers with intermolecular hydrogen bonding between the carboxylic acid groups and the nitrogen or oxygen of the amide side chains.

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