Total Synthesis of the Fumiquinazoline Alkaloids:  Solution-Phase Studies1

2000 ◽  
Vol 65 (4) ◽  
pp. 1022-1030 ◽  
Author(s):  
Haishan Wang ◽  
A. Ganesan
Keyword(s):  
Total Synthesis ◽  
Solution Phase

scholarly journals Total synthesis of TMG-chitotriomycin based on an automated electrochemical assembly of a disaccharide building block

2017 ◽  
Vol 13 ◽  
pp. 919-924 ◽  
Author(s):  
Yuta Isoda ◽  
Norihiko Sasaki ◽  
Kei Kitamura ◽  
Shuji Takahashi ◽  
Sujit Manmode ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Building Block ◽  
Building Blocks ◽  
Solution Phase ◽  
Protecting Groups ◽  
Phase Synthesis ◽  
Solution Phase Synthesis

The total synthesis of TMG-chitotriomycin using an automated electrochemical synthesizer for the assembly of carbohydrate building blocks is demonstrated. We have successfully prepared a precursor of TMG-chitotriomycin, which is a structurally-pure tetrasaccharide with typical protecting groups, through the methodology of automated electrochemical solution-phase synthesis developed by us. The synthesis of structurally well-defined TMG-chitotriomycin has been accomplished in 10-steps from a disaccharide building block.

scholarly journals First total synthesis of versicotide A, B and C

RSC Advances ◽  
2020 ◽  
Vol 10 (71) ◽  
pp. 43653-43659
Author(s):  
Laura Posada ◽  
Danilo Davyt ◽  
Gloria Serra
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anthranilic Acid ◽  
Solution Phase ◽  
Fmoc Spps

Versicotides A–C, natural products containig anthranilic acid and NMe-Ala, were prepared by Fmoc/SPPS and solution phase macrocyclization.

Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag

Tetrahedron ◽  
2011 ◽  
Vol 67 (35) ◽  
pp. 6633-6643 ◽  
Author(s):  
Tomoyasu Hirose ◽  
Takako Kasai ◽  
Takafumi Akimoto ◽  
Ayako Endo ◽  
Akihiro Sugawara ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Solution Phase

scholarly journals Hybrid phase ligation for efficient synthesis of histone proteins

2016 ◽  
Vol 14 (9) ◽  
pp. 2603-2607 ◽  
Author(s):  
Ruixuan R. Yu ◽  
Santosh K. Mahto ◽  
Kurt Justus ◽  
Mallory M. Alexander ◽  
Cecil J. Howard ◽  
...  
Keyword(s):  
Solid Solution ◽  
Total Synthesis ◽  
Solid Phase ◽  
Solution Phase ◽  
Solid Solution Phase ◽  
Efficient Synthesis ◽  
Histone Proteins

We report a hybrid solid-solution phase ligation approach that combines the efficiency of solid phase ligation with solution phase ligation in the total synthesis of modified histone proteins.

scholarly journals A formal synthesis of Balgacyclamide A using solution phase fragments condensation.

2020 ◽  
Author(s):  
Sandip Radhakisan Ugale ◽  
Somnath S Gholap
Keyword(s):  
Amino Acids ◽  
Total Synthesis ◽  
Spectral Data ◽  
Microcystis Aeruginosa ◽  
Solution Phase ◽  
Formal Synthesis ◽  
H Nmr ◽  
The Core ◽  
C Nmr

Abstract: A formal total synthesis of Balgacyclamide A as an antimalarial cynobactin of Microcystis aeruginosa (EAWAG 251) has been described. The synthesis of titled cyclamide was accomplished by the solution phase fragment synthesis using protection, deprotection and macrocylization process. Four common amino acids such as d-alanine, l-threonine, l-valine and d-allo-isoleucine, has been used for the construction of Balgacyclamide A. Including, the oxazoline and thiazole are the core structures was successfully achieved by using Burgess reagent and Hantzsch methods. The overall yield of the synthesized balgacyclamide A was found to be 2.03%, also structure was confirmed by1H-NMR, 13C-NMR and HRMS spectral data.

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