Total Synthesis of Distamycin A and 2640 Analogues:  A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity

2000 ◽  
Vol 122 (27) ◽  
pp. 6382-6394 ◽  
Author(s):  
Dale L. Boger ◽  
Brian E. Fink ◽  
Michael P. Hedrick
Keyword(s):  
Dna Binding ◽  
Total Synthesis ◽  
High Throughput ◽  
Solution Phase ◽  
Combinatorial Approach ◽  
Distamycin A ◽  
Binding Agents ◽  
Dna Binding Agents ◽  
Dna Binding Affinity ◽  
Binding Sequence

Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents

2000 ◽  
Vol 8 (8) ◽  
pp. 2049-2057 ◽  
Author(s):  
Dale L. Boger ◽  
Michael A. Dechantsreiter ◽  
Takahiro Ishii ◽  
Brian E. Fink ◽  
Michael P. Hedrick
Keyword(s):  
Dna Binding ◽  
Solution Phase ◽  
Distamycin A ◽  
Positional Scanning ◽  
Binding Agents ◽  
Dna Binding Agents ◽  
Positional Scanning Libraries

Specific activation of transcription initiation by the sequence-specific DNA-binding agents distamycin A and netropsin

Biochemistry ◽  
1987 ◽  
Vol 26 (3) ◽  
pp. 950-956 ◽  
Author(s):  
James P. Bruzik ◽  
David T. Auble ◽  
Pieter L. DeHaseth
Keyword(s):  
Dna Binding ◽  
Transcription Initiation ◽  
Distamycin A ◽  
Activation Of Transcription ◽  
Binding Agents ◽  
Dna Binding Agents

scholarly journals Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library

2010 ◽  
Vol 20 (5) ◽  
pp. 1685-1688 ◽  
Author(s):  
LaTeca S. Glass ◽  
Aditi Bapat ◽  
Mark R. Kelley ◽  
Millie M. Georgiadis ◽  
Eric C. Long
Keyword(s):  
Dna Binding ◽  
High Throughput ◽  
Compound Library ◽  
Binding Agents ◽  
Dna Binding Agents ◽  
Displacement Based ◽  
Fluorescent Intercalator Displacement ◽  
Large Compound

Total Synthesis of Proximicin A−C and Synthesis of New Furan-Based DNA Binding Agents

2009 ◽  
Vol 11 (13) ◽  
pp. 2804-2807 ◽  
Author(s):  
Falko E. Wolter ◽  
Kathrin Schneider ◽  
Brian P. Davies ◽  
Elke R. Socher ◽  
Graeme Nicholson ◽  
...  
Keyword(s):  
Dna Binding ◽  
Total Synthesis ◽  
Binding Agents ◽  
Dna Binding Agents

scholarly journals A High-Throughput, High-Resolution Strategy for the Study of Site-Selective DNA Binding Agents:  Analysis of a “Highly Twisted” Benzimidazole-Diamidine

2006 ◽  
Vol 128 (24) ◽  
pp. 7846-7854 ◽  
Author(s):  
Kristie D. Goodwin ◽  
Mark A. Lewis ◽  
Farial A. Tanious ◽  
Richard R. Tidwell ◽  
W. David Wilson ◽  
...  
Keyword(s):  
High Resolution ◽  
Dna Binding ◽  
High Throughput ◽  
Binding Agents ◽  
Dna Binding Agents ◽  
Resolution Strategy ◽  
Selective Dna Binding ◽  
Site Selective

Binding mode and affinity studies of DNA-binding agents using topoisomerase I DNA unwinding assay

2007 ◽  
Vol 17 (4) ◽  
pp. 1013-1017 ◽  
Author(s):  
Ruel E. McKnight ◽  
Aaron B. Gleason ◽  
James A. Keyes ◽  
Sadia Sahabi
Keyword(s):  
Dna Binding ◽  
Topoisomerase I ◽  
Binding Mode ◽  
Dna Unwinding ◽  
Binding Agents ◽  
Dna Binding Agents
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