Structural Spectroscopy and Dynamics of Inter- and Intramolecular H-Bonding Interactions of Topotecan, a Potent Anticancer Drug, in Organic Solvents and in Aqueous Solution

2012 ◽  
Vol 116 (25) ◽  
pp. 7522-7530 ◽  
Author(s):  
Maria Rosaria di Nunzio ◽  
YiLun Wang ◽  
Abderrazzak Douhal
Keyword(s):  
Aqueous Solution ◽  
Organic Solvents ◽  
Anticancer Drug

A Simple Synthesis of the Anticancer Drug Altretamine

2020 ◽  
Vol 17 (8) ◽  
pp. 628-630
Author(s):  
Vu Binh Duong ◽  
Pham Van Hien ◽  
Tran Thai Ngoc ◽  
Phan Dinh Chau ◽  
Tran Khac Vu
Keyword(s):  
Aqueous Solution ◽  
Anticancer Drug ◽  
Potassium Hydroxide ◽  
Large Scale ◽  
Synthesis Method ◽  
Practical Method ◽  
Cyanuric Chloride ◽  
Simple Synthesis ◽  
High Yield ◽  
One Step

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

scholarly journals Reverse vesicles as a new system for studying enzymes in organic solvents

1992 ◽  
Vol 285 (2) ◽  
pp. 373-376 ◽  
Author(s):  
A Sánchez-Ferrer ◽  
F García-Carmona
Keyword(s):  
Aqueous Solution ◽  
Organic Solvents ◽  
Reverse Micelles ◽  
Active Form ◽  
Ionic Surfactant ◽  
New Approach ◽  
Optically Transparent ◽  
Reverse Vesicles ◽  
Dodecyl Ether ◽  
New System

A new approach to the study of enzyme activity in organic solvents has been developed by using optically transparent reverse vesicles. Polyphenol oxidase was incorporated in an active form into the above ternary system formed by the non-ionic surfactant tetra(ethylene glycol) dodecyl ether/n-dodecane/water. The enzyme in this microenvironment, surprisingly, showed an apparent positive co-operativity which has never before been described either in aqueous solution or in reverse micelles. In addition, the Vmax. expressed was similar to that in water and twice that displayed in reverse micelles.

scholarly journals Stability of Anticancer Drug 5-Fluorouracil in Aqueous Solution: An Assessment of Kinetic Behavior

2018 ◽  
Vol 10 (3) ◽  
Author(s):  
Razzaq Abd Al-Zahra Ibrahim ◽  
Falah Shareef Abed Suhail ◽  
Hussein Kadhem Al-Hakeim
Keyword(s):  
Aqueous Solution ◽  
Anticancer Drug ◽  
Kinetic Behavior

On the High Viscosity of Aqueous Solution of Lysozyme Induced by Some Organic Solvents

1996 ◽  
Vol 180 (2) ◽  
pp. 578-589 ◽  
Author(s):  
Elizabeth P.G. Arêas ◽  
José A.G. Arêas ◽  
James Hamburger ◽  
Warner L. Peticolas ◽  
Paulo S. Santos
Keyword(s):  
Aqueous Solution ◽  
Organic Solvents ◽  
High Viscosity
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