Investigation of Nanoscale Interactions by Means of Subharmonic Excitation

2012 ◽  
Vol 3 (16) ◽  
pp. 2125-2129 ◽  
Author(s):  
Matteo Chiesa ◽  
Karim Gadelrab ◽  
Marco Stefancich ◽  
Peter Armstrong ◽  
Guang Li ◽  
...  
Keyword(s):  
Nanoscale Interactions ◽  
Subharmonic Excitation

scholarly journals Glycocalyx-mediated Cell Adhesion and Migration

2020 ◽  
Author(s):  
Samuel Schmidt ◽  
Bettina Weigelin ◽  
Joost te Riet ◽  
Veronika te Boekhorst ◽  
Mariska te Lindert ◽  
...  
Keyword(s):  
Cell Attachment ◽  
Adaptive Process ◽  
Nanoscale Interactions ◽  
Cell Adhesion And Migration ◽  
3D Environments ◽  
And Migration ◽  
Force Range ◽  
Membrane Deformations

SummaryCell migration is a force-dependent adaptive process mediated by integrin-dependent adhesion as well as other yet poorly defined interactions to the extracellular matrix. Using enzymatic multi-targeted digestion of sugar moieties on the surface of mesenchymal cells and leukocytes after interference with integrin function, we demonstrate that the surface glycocalyx represents an independent adhesion system. The glycocalyx mediates cell attachment to ECM ligand in the 100-500 pN force range and amoeboid migration in 3D environments in vitro and in vivo. Glycan-based adhesions consist of actin-rich membrane deformations and appositions associated with bleb-like and other protrusions forming complex-shaped sub-micron contact sites to ECM fibrils. These data implicate the glycocalyx in mediating generic stickiness to support nanoscale interactions (nanogrips) between the cell surface and ECM, mechano-coupling, and migration.

scholarly journals Proving Nanoscale Chiral Interactions of Cyclodextrins and Propranolol Enantiomers by Means of SERS Measurements Performed on a Solid Plasmonic Substrate

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1594
Author(s):  
Gabriela Fabiola Știufiuc ◽  
Valentin Toma ◽  
Anca Onaciu ◽  
Vasile Chiș ◽  
Constantin Mihai Lucaciu ◽  
...  
Keyword(s):  
Interaction Strength ◽  
Chiral Discrimination ◽  
Intermolecular Complexes ◽  
Starting Point ◽  
Surface Enhanced Raman ◽  
Nanoscale Interactions ◽  
New Type ◽  
Vibrational Bands ◽  
Good Starting Point ◽  
Working Principle

Chiral separation is an important issue for the pharmaceutical industry. Over the years, several separation methods have been developed, mainly based on chromatography. Their working principle is based on the formation of transient diastereoisomers, but the very subtle nanoscale interactions responsible for separation are not always understood. Recently, Raman and surface-enhanced Raman (SERS) spectroscopy have provided promising results in this field. Here we present Raman/SERS experimental data that provide useful information concerning the nanoscale interactions between propranolol enantiomers and α, β, and γ cyclodextrins. Raman spectroscopy was used to prove the formation of host–guest intermolecular complexes having different geometries of interaction. The occurrence of new vibrational bands and a change in the intensities of others are direct proofs of complexes’ formation. These observations were confirmed by DFT calculations. By performing SERS measurements on a new type of plasmonic substrate, we were able to prove the intermolecular interactions responsible for PRNL discrimination. It turned out that the interaction strength between the substrate and the intermolecular complexes is of paramount importance for SERS-based chiral discrimination. This approach could represent a very good starting point for the evaluation of molecular interactions manifesting between other pharmaceutical compounds and different classes of chiral selectors.

Nano-Optical Image-Making: Morphologies, Devices, Speculations

Leonardo ◽  
2020 ◽  
Vol 53 (2) ◽  
pp. 167-173
Author(s):  
Aleksandra Kaminska
Keyword(s):  
Optical Image ◽  
Structural Color ◽  
Optical Images ◽  
Nanoscale Interactions ◽  
Designed Materials ◽  
Visual Technologies

This article provides a technical overview of nano-optical image-making produced in collaboration between the author, engineering scientists at the Ciber Lab in Vancouver and the artists Christine Davis and Scott Lyall. It situates the work in relation to other optical technologies (such as holographs), to the primary application of nano-optical images as authentication devices and to other artistic practices concerning nanoscale interactions of light and matter. The paper articulates the convergence of visual technologies and designed materials by explaining how the principles of structural color can be used for the production of images. Building a discussion on the shift from device to medium that is anchored around questions of remediation and reproducibility, it concludes with a speculation on informatic matters, or the convergence of mediating functions at the surface of things.

ULTRAFINE GRAINED AND NANOSTRUCTURED MATERIALS FOR ADVANCED ENERGY APPLICATIONS

2008 ◽  
Vol 22 (18n19) ◽  
pp. 2887-2895 ◽  
Author(s):  
CONSTANTIN POLITIS
Keyword(s):  
Ball Milling ◽  
Power Plants ◽  
Nuclear Reactor ◽  
Fission Products ◽  
High Energy ◽  
Interfacial Behavior ◽  
First Wall ◽  
Energy Applications ◽  
Ultrafine Grained ◽  
Nanoscale Interactions

The understanding of nanoscale interactions of nuclear materials will help to mastering the complex behavior of actinides and of fission products, and the interfacial behavior of fuel-cladding under extreme conditions. Ultrafine grained and nanostructured engineering materials are also suggested as protective armors on the plasma-facing first wall of D-T fusion power plants. We review the constitution and preparation by arc-melting and ball milling of ultrafine grained materials for the advanced nuclear reactor fuels UC, UC-W, UN, UN- Mo , and UN-W. We report also the preparation of the first wall armour materials nano-W, nano W-Y alloys, nano-graphite, and nano- B 4 C by high energy ball milling and their characterization by metallography, XRD, DSC and HRTEM.

Label-Free Method Using a Weighted-Phase Algorithm To Quantitate Nanoscale Interactions between Molecules on DNA Microarrays

2017 ◽  
Vol 89 (6) ◽  
pp. 3501-3507 ◽  
Author(s):  
Qi Li ◽  
Rongxin Fu ◽  
Junqi Zhang ◽  
Ruliang Wang ◽  
Jiancheng Ye ◽  
...  
Keyword(s):  
Dna Microarrays ◽  
Label Free ◽  
Nanoscale Interactions
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