Protein-Resistant Self-Assembled Monolayers on Gold with Latent Aldehyde Functions

Langmuir ◽  
2007 ◽  
Vol 23 (10) ◽  
pp. 5571-5577 ◽  
Author(s):  
Martin Hölzl ◽  
Ali Tinazli ◽  
Christa Leitner ◽  
Christoph D. Hahn ◽  
Bernd Lackner ◽  
...  
2010 ◽  
Vol 5 (2) ◽  
pp. 30-36 ◽  
Author(s):  
Laxman Kankate ◽  
Udo Werner ◽  
Andrey Turchanin ◽  
Armin Gölzhäuser ◽  
Helge Großmann ◽  
...  

1991 ◽  
Vol 237 ◽  
Author(s):  
Kevin L. Prime ◽  
George M. Whttesides

ABSTRACTSelf-assembled monolayers (SAMs) of functionalized alkanethiolates on gold are a well-characterized system for studying the interfacial properties of organic materials. We have used SAMs as models for the surfaces of organic polymers and used mem to study the adsorption of proteins onto organic materials. We have formed SAMs from mixtures of alkanethiols in which one alkanethiol is hydrophobic and the other is terminated by a short (2 ≤ n ≤ 17) oligomer of poly(ethylene oxide). These “mixed” SAMs effectively resist the adsorption of fibrinogen from moderately concentrated (1 mg/mL) solutions. Protein adsorption begins when < 5% of the accessible area of the surface consists of hydrophobic groups. These findings suggest that real protein-resistant monolayers must present an almost defect-free surface of oligo(ethylene oxide) groups in order to eliminate adsorption.


2007 ◽  
Vol 138 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Christoph D. Hahn ◽  
Ali Tinazli ◽  
Martin Hölzl ◽  
Christa Leitner ◽  
Filip Frederix ◽  
...  

1998 ◽  
Vol 95 (6) ◽  
pp. 1339-1342 ◽  
Author(s):  
R. Michalitsch ◽  
A. El Kassmi ◽  
P. Lang ◽  
A. Yassar ◽  
F. Garnier

2003 ◽  
Vol 104 ◽  
pp. 459-462 ◽  
Author(s):  
R. Klauser ◽  
M. Zharnikov ◽  
I.-H. Hong ◽  
S.-C. Wang ◽  
A. Gölzhäuser ◽  
...  

2009 ◽  
Vol 25 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Guo-Qiang TAN ◽  
Hai-Yang BO ◽  
Hong-Yan MIAO ◽  
Ao XIA ◽  
Zhong-Liang HE

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