Self-Assembled Monolayers as Models for Studying Protein Adsorption to Polymer Surfaces

1991 ◽  
Vol 237 ◽  
Author(s):  
Kevin L. Prime ◽  
George M. Whttesides
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Organic Materials ◽  
Polymer Surfaces ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Protein Resistant ◽  
Poly Ethylene

ABSTRACTSelf-assembled monolayers (SAMs) of functionalized alkanethiolates on gold are a well-characterized system for studying the interfacial properties of organic materials. We have used SAMs as models for the surfaces of organic polymers and used mem to study the adsorption of proteins onto organic materials. We have formed SAMs from mixtures of alkanethiols in which one alkanethiol is hydrophobic and the other is terminated by a short (2 ≤ n ≤ 17) oligomer of poly(ethylene oxide). These “mixed” SAMs effectively resist the adsorption of fibrinogen from moderately concentrated (1 mg/mL) solutions. Protein adsorption begins when < 5% of the accessible area of the surface consists of hydrophobic groups. These findings suggest that real protein-resistant monolayers must present an almost defect-free surface of oligo(ethylene oxide) groups in order to eliminate adsorption.

Helical, Disordered, and What that Means: Structural Characterization of a New Series of Methyl 1-Thiaoligo(ethylene Oxide) Self-Assembled Monolayers

2002 ◽  
Vol 724 ◽  
Author(s):  
David J. Vanderah ◽  
Jennifer Arsenault ◽  
Hongly La ◽  
Vitalii Silin ◽  
Curtis W. Meuse ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Helical Structure ◽  
Helical Conformation ◽  
Self Assembled Monolayers ◽  
Reflection Absorption Infrared Spectroscopy ◽  
Assembled Monolayers ◽  
Polycrystalline Gold ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Poly Ethylene

AbstractSelf-assembled monolayers (SAMs) of a series of linear thiols containing a 1-thiaoligo(ethylene oxide) [TOEO] moiety, i.e., HS(CH2CH2O)xCH3, where x = 3 - 6, were prepared on polycrystalline gold (Au) and characterized by reflection absorption infrared spectroscopy (RAIRS) and spectroscopic ellipsometry (SE). For x = 5 and 6, the RAIRS data show that the TOEO segment, oriented normal to the substrate, adopts the highly ordered 7/2 helical structure of the folded-chain crystal polymorph of poly(ethylene oxide). For x = 3 and 4, the RAIRS and SE data indicate disordered, “amorphous” SAMs with essentially no evidence of the helical conformation in the TOEO segment. These data suggest that, for SAMs with TOEO segments, a minimum of five ethylene oxide units is required to adopt a helical conformation.

Self-Assembled Monolayers of Methyl 1-Thiahexa(ethylene oxide) for the Inhibition of Protein Adsorption

Langmuir ◽  
2002 ◽  
Vol 18 (12) ◽  
pp. 4674-4680 ◽  
Author(s):  
David J. Vanderah ◽  
Gintaras Valincius ◽  
Curtis W. Meuse
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Self Assembled

Poly(ethylene oxide) Grafted to Silicon Surfaces: Grafting Density and Protein Adsorption

1998 ◽  
Vol 31 (15) ◽  
pp. 5059-5070 ◽  
Author(s):  
Susan J. Sofia ◽  
V. Premnath ◽  
Edward W. Merrill
Keyword(s):  
Ethylene Oxide ◽  
Protein Adsorption ◽  
Silicon Surfaces ◽  
Grafting Density ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Endothelial Cell Growth and Protein Adsorption on Terminally Functionalized, Self-Assembled Monolayers of Alkanethiolates on Gold

Langmuir ◽  
1997 ◽  
Vol 13 (13) ◽  
pp. 3404-3413 ◽  
Author(s):  
Caren D. Tidwell ◽  
Sylvie I. Ertel ◽  
Buddy D. Ratner ◽  
Barbara J. Tarasevich ◽  
Sundar Atre ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Assembled Monolayers ◽  
Endothelial Cell Growth ◽  
Self Assembled

Enantiopure Chiral Poly(glycerol methacrylate) Self-Assembled Monolayers Knock Down Protein Adsorption and Cell Adhesion

2013 ◽  
Vol 2 (10) ◽  
pp. 1377-1387 ◽  
Author(s):  
Zheng Li ◽  
Alexander Köwitsch ◽  
Guoying Zhou ◽  
Thomas Groth ◽  
Bodo Fuhrmann ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Protein Adsorption ◽  
Self Assembled Monolayers ◽  
Knock Down ◽  
Assembled Monolayers ◽  
Self Assembled

Protein-Resistant Silicones:  Incorporation of Poly(ethylene oxide) via Siloxane Tethers

2007 ◽  
Vol 8 (10) ◽  
pp. 3244-3252 ◽  
Author(s):  
Ranjini Murthy ◽  
Casey D. Cox ◽  
Mariah S. Hahn ◽  
Melissa A. Grunlan
Keyword(s):  
Ethylene Oxide ◽  
Poly Ethylene Oxide ◽  
Protein Resistant ◽  
Poly Ethylene
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