Defeating antibiotic-resistant bacteria with protein-resistant polyGGE film

Biofouling on medical device surfaces, which is initiated by protein adsorption and adhesion of microbes especially the antibiotic-resistant bacteria, attracts global attention for centuries due to its enduring challenges in healthcare. Here, the antifouling effect of hydrophilic poly(glycerol glycidyl ether) (polyGGE) film is explored in comparison to hemocompatible and protein-resistant control polymers. The chemical and thermomechanical stability of polyGGE in hydrated conditions at body temperature was achieved via adjusting UV curing and KOH quenching time. The polyGGE surface is inert to the plasma protein adsorption and interfered the metabolism conditions, biofilm formation and growth of both Gram negative (Gram–) and antibiotic-resistant Gram positive (Gram+) bacteria. These results indicate the potential application of polyGGE for combating the risk of hospital-acquired infections and preventing drug-resistant superbug spreading.

Antifouling Technology Trends in Marine Environmental Protection

Marine fouling is a worldwide problem, which is harmful to the global marine ecological environment and economic benefits. The traditional antifouling strategy usually uses toxic antifouling agents, which gradually exposes a serious environmental problem. Therefore, green, long-term, broad-spectrum and eco-friendly antifouling technologies have been the main target of engineers and researchers. In recent years, many eco-friendly antifouling technologies with broad application prospects have been developed based on the low toxicity and non-toxicity antifouling agents and materials. In this review, contemporary eco-friendly antifouling technologies and materials are summarized into bionic antifouling and non-bionic antifouling strategies (2000–2020). Non-bionic antifouling technologies mainly include protein resistant polymers, antifoulant releasing coatings, foul release coatings, conductive antifouling coatings and photodynamic antifouling technology. Bionic antifouling technologies mainly include the simulated shark skin, whale skin, dolphin skin, coral tentacles, lotus leaves and other biology structures. Brief future research directions and challenges are also discussed in the end, and we expect that this review would boost the development of marine antifouling technologies.

Use of Protein Repellents to Enhance the Antimicrobial Functionality of Quaternary Ammonium Containing Dental Materials

An advancement in preventing secondary caries has been the incorporation of quaternary ammonium containing (QAC) compounds into a composite resin mixture. The permanent positive charge on the monomers allows for electrostatic-based killing of bacteria. Spontaneous adsorption of salivary proteins onto restorations dampens the antimicrobial capabilities of QAC compounds. Protein-repellent monomers can work with QAC restorations to achieve the technology’s full potential. We discuss the theory behind macromolecular adsorption, direct and indirect characterization methods, and advances of protein repellent dental materials. The translation of protein adsorption to microbial colonization is covered, and the concerns and fallbacks of the state-of-the-art protein-resistant monomers are addressed. Last, we present new and exciting avenues for protein repellent monomer design that have yet to be explored in dental materials.