Structural Modification of a Periodic Polypeptide through Biosynthetic Replacement of Proline with Azetidine-2-carboxylic Acid

1996 ◽  
Vol 29 (5) ◽  
pp. 1442-1444 ◽  
Author(s):  
Timothy J. Deming ◽  
Maurille J. Fournier ◽  
Thomas L. Mason ◽  
David A. Tirrell
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification

Structural modification and new methods for preparation of ofloxacin analogs

1991 ◽  
Vol 56 (9) ◽  
pp. 1937-1943 ◽  
Author(s):  
Stanislav Rádl ◽  
Lenka Kovářová ◽  
Jaroslav Moural ◽  
Radoslava Bendová
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification ◽  
Sodium Hydrogen Carbonate ◽  
Methyl Derivative ◽  
New Methods ◽  
Sodium Hydrogen ◽  
Hydrogen Carbonate ◽  
Alkaline Conditions ◽  
Methylene Derivative

Reaction of ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate IIb with 2-amino-1-propanol provided corresponding compound IIIb which under alkaline conditions underwent an aromatic denitrocyclization reaction which after alkaline saponification provided 10-chloro-9-fluoro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Vd. Treatment of 8-hydroxyquinolone VIII with 3-bromopropyne in the presence of sodium hydrogen carbonate provided methylene derivative VIIb which was saponified into a appropriate acid VIIc. Compound VIIb treated with N-methylpiperazine and then saponified yielded VIIa. Hydrogenation of 3-methylene derivative VIIb provided 3-methyl derivative Va.

ChemInform Abstract: Synthesis and Structural Modification of tert-Butyl Ester of 7α-Chloro-2- (N,N-dimethylaminomethylene)-3-methyl-1,1-dioxoceph-3-em-4-carboxylic Acid.

ChemInform ◽  
2008 ◽  
Vol 39 (5) ◽  
Author(s):  
M. Vorona ◽  
I. Potorocina ◽  
G. Veinberg ◽  
I. Shestakova ◽  
I. Kanepe ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification ◽  
Butyl Ester ◽  
Tert Butyl

Synthesis and structural modification of tert-butyl ester of 7α-chloro-2-(N,N-dimethylaminomethylene)-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid

2007 ◽  
Vol 43 (5) ◽  
pp. 646-652 ◽  
Author(s):  
M. Vorona ◽  
I. Potoročina ◽  
G. Veinberg ◽  
I. Shestakova ◽  
I. Kanepe ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification ◽  
Butyl Ester ◽  
Tert Butyl

Preferred formation of the carboxylic acid–pyridine heterosynthon in 2-anilinonicotinic acids

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 81101-81109 ◽  
Author(s):  
Peng Chen ◽  
Zhifei Zhang ◽  
Sean Parkin ◽  
Panpan Zhou ◽  
Kai Cheng ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Nicotinic Acid ◽  
Structural Modification

Preferred formation of carboxylic acid–pyridine heterosynthon in 2-(phenylamino)nicotinic acid was realized through structural modification of the N bridge.

Cristal-growth dynamics of n-doped gaAs

1992 ◽  
Vol 50 (2) ◽  
pp. 1544-1545
Author(s):  
Pham V. Huong ◽  
Stéphanie Bouchet ◽  
Jean-Claude Launay
Keyword(s):  
Crystal Growth ◽  
Spatial Resolution ◽  
Epitaxial Layer ◽  
Outer Surface ◽  
Gaas Substrate ◽  
Structural Modification ◽  
Growth Dynamics ◽  
Argon Laser ◽  
High Anisotropy ◽  
Crystal Gaas

Microstructure of epitaxial layers of doped GaAs and its crystal growth dynamics on single crystal GaAs substrate were studied by Raman microspectroscopy with a Dilor OMARS instrument equipped with a 1024 photodiode multichannel detector and a ion-argon laser Spectra-Physics emitting at 514.5 nm.The spatial resolution of this technique, less than 1 μm2, allows the recording of Raman spectra at several spots in function of thickness, from the substrate to the outer deposit, including areas around the interface (Fig.l).The high anisotropy of the LO and TO Raman bands is indicative of the orientation of the epitaxial layer as well as of the structural modification in the deposit and in the substrate at the interface.With Sn doped, the epitaxial layer also presents plasmon in Raman scattering. This fact is already very well known, but we additionally observed that its frequency increases with the thickness of the deposit. For a sample with electron density 1020 cm-3, the plasmon L+ appears at 930 and 790 cm-1 near the outer surface.

Soft recovery of a ferrous alloy: Structural modification and properties

2009 ◽  
Author(s):  
T. d'Almeida ◽  
D. J. Chapman ◽  
W. G. Proud ◽  
P. J. Gould ◽  
P. D. Church ◽  
...  
Keyword(s):  
Structural Modification ◽  
Ferrous Alloy

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

1969 ◽  
Vol 21 (02) ◽  
pp. 294-303 ◽  
Author(s):  
H Mihara ◽  
T Fujii ◽  
S Okamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Carboxylic Acid ◽  
Fibrinolytic Activity ◽  
Clinical Implications ◽  
Trans Form ◽  
Plate Method ◽  
Blood Samples ◽  
Fibrin Plate ◽  
The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

Sign in / Sign up

Export Citation Format

Share Document