scholarly journals In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy

ACS Nano ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. 679-679 ◽  
Author(s):  
Linlin Li ◽  
Fangqiong Tang ◽  
Huiyu Liu ◽  
Tianlong Liu ◽  
Nanjing Hao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
High Efficacy ◽  
Low Toxicity ◽  
Silica Nanorattle ◽  
In Vivo Delivery

In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy

ACS Nano ◽  
2010 ◽  
Vol 4 (11) ◽  
pp. 6874-6882 ◽  
Author(s):  
Linlin Li ◽  
Fangqiong Tang ◽  
Huiyu Liu ◽  
Tianlong Liu ◽  
Nanjing Hao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
High Efficacy ◽  
Low Toxicity ◽  
Silica Nanorattle ◽  
In Vivo Delivery

scholarly journals Folate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Huiling Lv ◽  
Chao Wu ◽  
Xuan Liu ◽  
Andi Bai ◽  
Yue Cao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Drug Carrier ◽  
In Vitro Release ◽  
Hollow Structure ◽  
Amorphous State ◽  
Outer Diameter ◽  
Drug Delivery Carrier

In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.

Uniform hollow mesoporous silica nanocages for drug delivery in vitro and in vivo for liver cancer therapy

2011 ◽  
Vol 21 (14) ◽  
pp. 5299 ◽  
Author(s):  
Tingting Wang ◽  
Fang Chai ◽  
Qin Fu ◽  
Lingyu Zhang ◽  
Haiyan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Liver Cancer ◽  
Mesoporous Silica ◽  
Hollow Mesoporous Silica

In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity

2013 ◽  
Vol 441 (1-2) ◽  
pp. 728-735 ◽  
Author(s):  
Yancai Wang ◽  
Yingying Ma ◽  
Ying Zheng ◽  
Ju Song ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Anticancer Activity ◽  
High Efficacy ◽  
Low Toxicity

scholarly journals Preparation, Characterization and Preliminary in vivo Testing of Liposomated Antiidiotypic Antibodies Against Morphine Derivatives

Biomeditsina ◽  
2021 ◽  
Vol 17 (4) ◽  
pp. 8-17
Author(s):  
V. N. Karkischenko ◽  
A. G. Berzina ◽  
T. A. Klimova ◽  
N. B. Gamaleya ◽  
R. A. Ageldinov ◽  
...  
Keyword(s):  
Immune Response ◽  
New Drugs ◽  
High Efficacy ◽  
Artificial Membrane ◽  
Membrane Structures ◽  
Medicinal Substances ◽  
Low Toxicity ◽  
Antiidiotypic Antibodies ◽  
Immunogenic Properties

Artificial membrane structures containing medicinal substances are highly promising for the development of new drugs. Liposomal preparations are actively used in medical practice due to their high efficacy and relatively low toxicity. Our aim was to encapsulate anti-idiotypic antibodies into a liposomal composition with the purpose of improving their immunogenic properties. Following the preparation of a liposomal composition by the dehydration/rehydration method using ultrasonic treatment, the size, zeta potential, and loading efficiency of liposomes were investigated. Preliminary in vivo studies were conducted to evaluate the adjuvant properties of liposomes of varying size. Loaded liposomes of the smallest diameter (about 110 nm) showed the potential of enhancing the immune response similar to that obtained using Freund’s adjuvant. These results justify further research into the properties of liposomes loaded with antibodies.

scholarly journals The Good, the Bad, the Question–H19 in Hepatocellular Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1261 ◽  
Author(s):  
Lysann Tietze ◽  
Sonja M. Kessler
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Therapy ◽  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Human Patient ◽  
In Vivo Models ◽  
Study Results ◽  
Novel Target

Hepatocellular carcinoma (HCC), the most common primary liver cancer, is challenging to treat due to its typical late diagnosis, mostly at an advanced stage. Therefore, there is a particular need for research in diagnostic and prognostic biomarkers and therapeutic targets for HCC. The use of long noncoding (lnc) RNAs can widen the list of novel molecular targets improving cancer therapy. In hepatocarcinogenesis, the role of the lncRNA H19, which has been known for more than 30 years now, is still controversially discussed. H19 was described to work either as a tumor suppressor in vitro and in vivo, or to have oncogenic features. This review attempts to survey the conflicting study results and tries to elucidate the potential reasons for the contrary findings, i.e., different methods, models, or readout parameters. This review encompasses in vitro and in vivo models as well as studies on human patient samples. Although the function of H19 in HCC remains elusive, a short outlook summarizes some ideas of using the H19 locus as a novel target for liver cancer therapy.

scholarly journals In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

2015 ◽  
Vol 81 ◽  
pp. 128-141 ◽  
Author(s):  
Yunching Chen ◽  
Dong-Yu Gao ◽  
Leaf Huang
Keyword(s):  
Cancer Therapy ◽  
In Vivo Delivery ◽  
Challenges And Strategies

Ultrasound-Guided in Vivo Delivery of Cold Plasma Gas for Cancer Therapy via Microbubbles

2021 ◽  
Author(s):  
Wenyu Guo ◽  
Shuo Huang ◽  
Jie Dang ◽  
Jian An ◽  
Feihong Dong ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cold Plasma ◽  
Ultrasound Guided ◽  
In Vivo Delivery

Comprehensively enhanced delivery cascade by transformable beaded nanofibrils for pancreatic cancer therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Qinglin Sheng ◽  
Ting Li ◽  
Xian Tang ◽  
Wei Zhao ◽  
Rong Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Tumor Therapy ◽  
Pancreatic Cancer Therapy ◽  
Delivery Efficiency ◽  
In Vivo Delivery

Facing the barriers in each step of the in vivo delivery cascade, the low drug delivery efficiency remains a thorny problem in tumor therapy. Although recently the nanofibril drug delivery...

Current Trends in Phyto-cancer Therapy Using Nanoparticles

2019 ◽  
Vol 9 (1) ◽  
pp. 30-45 ◽  
Author(s):  
K. Vohra ◽  
H. Dureja ◽  
V. Garg ◽  
R. Dutt
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Herbal Medicines ◽  
High Efficacy ◽  
Global Challenge ◽  
Alternative Medicines ◽  
Current Trends ◽  
Low Toxicity ◽  
Novel Drug

Background:Cancer has been considered as a deadly disease and its appropriate management is still a global challenge. The traditional anticancer therapeutics have been able to combat the disease to some extent but with numerous adverse effects which affect the quality of life of patients.Method:The introduction of alternative medicines, especially herbal medicines, has attracted the scientists’ due to low toxicity and high efficacy associated with them. However, their poor solubility and bioavailability decrease their efficacy. This has led to the increased use of targeted drug delivery systems in phyto-cancer therapy.Results:Nanoparticles (NPs), a novel drug delivery system has been widely used in the recent years due to their various advantages such as drug targeting, improved solubility, and bioavailability, high efficacy, low toxicity towards normal cells, low drug resistance, high drug loading at tumor site, etc.Conclusion:These benefits have also been observed in studies evaluating phytonanotherapy in cancer. The present review highlights current trends followed by phyto-cancer therapy using NPs. The recent studies conducted on herbal NPs for cancer therapy have also been enlisted.

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