Current Trends in Phyto-cancer Therapy Using Nanoparticles

2019 ◽  
Vol 9 (1) ◽  
pp. 30-45 ◽  
Author(s):  
K. Vohra ◽  
H. Dureja ◽  
V. Garg ◽  
R. Dutt
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Herbal Medicines ◽  
High Efficacy ◽  
Global Challenge ◽  
Alternative Medicines ◽  
Current Trends ◽  
Low Toxicity ◽  
Novel Drug

Background:Cancer has been considered as a deadly disease and its appropriate management is still a global challenge. The traditional anticancer therapeutics have been able to combat the disease to some extent but with numerous adverse effects which affect the quality of life of patients.Method:The introduction of alternative medicines, especially herbal medicines, has attracted the scientists’ due to low toxicity and high efficacy associated with them. However, their poor solubility and bioavailability decrease their efficacy. This has led to the increased use of targeted drug delivery systems in phyto-cancer therapy.Results:Nanoparticles (NPs), a novel drug delivery system has been widely used in the recent years due to their various advantages such as drug targeting, improved solubility, and bioavailability, high efficacy, low toxicity towards normal cells, low drug resistance, high drug loading at tumor site, etc.Conclusion:These benefits have also been observed in studies evaluating phytonanotherapy in cancer. The present review highlights current trends followed by phyto-cancer therapy using NPs. The recent studies conducted on herbal NPs for cancer therapy have also been enlisted.

Transdermal Nutraceuticals Delivery System for CNS Disease

2022 ◽  
Vol 21 ◽  
Author(s):  
Mohammed Asadullah Jahangir ◽  
Pooja Jain ◽  
Rishabh Verma ◽  
Mohamad Taleuzzaman ◽  
Mohamed Jawed Ahsan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Targeted Delivery ◽  
Low Cost ◽  
Herbal Medicines ◽  
Global Market ◽  
Transdermal Drug Delivery System ◽  
Non Invasive ◽  
Alternative Medicines ◽  
Low Toxicity

Abstract: Herbal medicines are being used by humans since the oldest civilizations and have been an integral part of traditional and alternative medicines. In recent times, pharmaceutical and biomedical scientists are taking interest in developing nutraceutical-based medicines to overcome the side effects and adverse drug reactions caused by allopathic medicines. Nutraceuticals have started occupying the global market. Nutraceuticals have gained widespread acceptance due to their efficacy in treating difficult to treat diseases, low toxicity, low cost, easy accessibility, etc. Safety and efficacy are other important factors in the commercialization process of nutraceuticals. Different novel advanced drug delivery systems have been constantly studied to improve the efficacy and bioavailability of medicines obtained from herbal sources. The transdermal drug delivery system provides a potent alternative to the conventional method of using nutraceuticals. The development of transdermal system-based nutraceuticals could provide the advantage of enhanced bioavailability, improved solubility, bypass the first-pass metabolism, and targeted delivery of drugs in brain-related disorders. It additionally provides the advantage of being non-invasive. This article reviews the potential effects of various nutraceuticals, in brain-related disorders as well as trends in transdermal nano-systems to deliver such nutraceuticals. We would also focus on advantages, application as well as recent United States-based patents which emphasized emerging interest towards transdermal nutraceuticals in brain disorders.

scholarly journals Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

2013 ◽  
Vol 49 (4) ◽  
pp. 629-643 ◽  
Author(s):  
Swatantra Kumar Singh Kushwaha ◽  
Saurav Ghoshal ◽  
Awani Kumar Rai ◽  
Satyawan Singh
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Anticancer Therapy ◽  
Modern Times ◽  
Novel Drug Delivery System ◽  
Considerable Work ◽  
Novel Drug ◽  
High Drug Loading

Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.

Herbal Liposomes: Natural Network for Targeted Drug Delivery System

2021 ◽  
pp. 31-41
Author(s):  
Vijay R. Salunkhe ◽  
Prasanna S. Patil ◽  
Ganesh H. Wadkar ◽  
Somnath D. Bhinge
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Therapeutic Potential ◽  
Herbal Medicines ◽  
Lipid Solubility ◽  
Liposomal Formulations ◽  
Novel Drug ◽  
Herbal Formulations

Herbal medicines have tremendous therapeutic potential that can explored across various effective drug delivery system. Decoctions, herbal teas, tinctures, glyceritum, oxymel, and use much soap, herbal tablets, herbal capsules, and herbal cream, herbal books, and prepared the confection of the most commonly available forms of dosage. The less use of herbal formulations in recent decades due to their lack of standardization. It is possible to use plant extract and isolated constituents to overcome this problem. But these phytoconstituents are suffering from drawbacks, mostly due to problems with stability and low lipid solubility. Novel drug delivery such as liposomes plays an important role in problem solving. Infact, compliance with the patient also improves. The review article discusses the recent status of new herbal liposomal formulations and describes the different ways in which these formulations are prepared.

A novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13673-13683 ◽  
Author(s):  
Luyao Wang ◽  
Mengke Qu ◽  
Shiqi Huang ◽  
Yu Fu ◽  
Liuqing Yang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
High Efficacy ◽  
Prostate Cancer Therapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The current work has designed a novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy using the pHCT74 peptide.

scholarly journals Edible Ginger-derived Nano-lipids Loaded with Doxorubicin as a Novel Drug-delivery Approach for Colon Cancer Therapy

2016 ◽  
Vol 24 (10) ◽  
pp. 1783-1796 ◽  
Author(s):  
Mingzhen Zhang ◽  
Bo Xiao ◽  
Huan Wang ◽  
Moon Kwon Han ◽  
Zhan Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Cancer Therapy ◽  
Novel Drug ◽  
Delivery Approach

In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy

ACS Nano ◽  
2010 ◽  
Vol 4 (11) ◽  
pp. 6874-6882 ◽  
Author(s):  
Linlin Li ◽  
Fangqiong Tang ◽  
Huiyu Liu ◽  
Tianlong Liu ◽  
Nanjing Hao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
High Efficacy ◽  
Low Toxicity ◽  
Silica Nanorattle ◽  
In Vivo Delivery

scholarly journals 622. Oncolytic Adenoviruses Loaded With Active Drugs as a Novel Drug Delivery System for Cancer Therapy

2015 ◽  
Vol 23 ◽  
pp. S247
Author(s):  
Mariangela Garofalo ◽  
Barbara Iovine ◽  
Lukasz Kuryk ◽  
Cristian Capasso ◽  
Mari Hirvinen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oncolytic Adenoviruses ◽  
Novel Drug Delivery System ◽  
Novel Drug

scholarly journals Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

2015 ◽  
Vol 112 (10) ◽  
pp. 2978-2983 ◽  
Author(s):  
Tuo Wei ◽  
Chao Chen ◽  
Juan Liu ◽  
Cheng Liu ◽  
Paola Posocco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Drug Carrier ◽  
Drug Loading ◽  
Cancer Drug ◽  
Self Assembling

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

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