Palladium-Catalyzed Isobenzofuran Generation under Neutral Conditions via Oxidative Addition to Lactol Methyl Ether

<p>We report a Ni(0)-catalyzed cross coupling reaction between simple ketones and 1,3-dienes. A variety of a-allylic alkylation products were formed in an 1,2-addition manner with excellent regioselectivity. Water was found to significantly accelerate this transformation. A HO-Ni-H species generated from oxidative addition of Ni(0) to H<sub>2</sub>O is proposed to play a “dual role” in activating both the ketone and the diene substrate.</p>

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ChemInform Abstract: Retention of Configuration on the Oxidative Addition of P-H Bond to Platinum(0) Complexes: The First Straightforward Synthesis of Enantiomerically Pure P-Chiral Alkenylphosphinates via Palladium-Catalyzed Stereospecific Hydrophosphiny

ChemInform ◽

10.1002/chin.200235159 ◽

2010 ◽

Vol 33 (35) ◽

pp. no-no

Author(s):

Li-Biao Han ◽

Chang-Qiu Zhao ◽

Shun-ya Onozawa ◽

Midori Goto ◽

Masato Tanaka

Keyword(s):

Oxidative Addition ◽

Enantiomerically Pure ◽

Palladium Catalyzed

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Synthesis of a Water-Soluble o-Carborane Bearing Uracil Moiety Via Palladium Catalyzed Reaction under Essentially Neutral Conditions

Cancer Neutron Capture Therapy ◽

10.1007/978-1-4757-9567-7_24 ◽

1996 ◽

pp. 173-176

Author(s):

Hisao Nemoto ◽

Jianping Cai ◽

Yoshinori Yamamoto

Keyword(s):

Water Soluble ◽

Palladium Catalyzed ◽

Neutral Conditions

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Thiolate–palladium(iv) or sulfonium–palladate(0)? A theoretical study on the mechanism of palladium-catalyzed C–S bond formation reactions

Organic Chemistry Frontiers ◽

10.1039/c6qo00841k ◽

2017 ◽

Vol 4 (6) ◽

pp. 943-950 ◽

Cited By ~ 9

Author(s):

Dongdong Xu ◽

Xiaotian Qi ◽

Meng Duan ◽

Zhaoyuan Yu ◽

Lei Zhu ◽

...

Keyword(s):

Theoretical Study ◽

Bond Formation ◽

Oxidative Addition ◽

Palladium Catalyzed ◽

Catalytic Cycles ◽

Bond Formation Reactions

Thiolate–palladium(iv) intermediates are generated through oxidative addition in our suggested mechanisms, and are the key intermediates in these catalytic cycles.

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Cyclopentyl Methyl Ether: An Alternative Solvent for Palladium-Catalyzed Direct Arylation of Heteroaromatics

ChemSusChem ◽

10.1002/cssc.201000405 ◽

2011 ◽

Vol 4 (4) ◽

pp. 526-534 ◽

Cited By ~ 51

Author(s):

Kassem Beydoun ◽

Henri Doucet

Keyword(s):

Methyl Ether ◽

Direct Arylation ◽

Palladium Catalyzed

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A denitrogenative palladium-catalyzed cascade for regioselective synthesis of fluorenes

Chemical Science ◽

10.1039/c9sc04062e ◽

2020 ◽

Vol 11 (5) ◽

pp. 1411-1417 ◽

Cited By ~ 3

Author(s):

Wai Chung Fu ◽

Fuk Yee Kwong

Keyword(s):

Oxidative Addition ◽

Regioselective Synthesis ◽

Palladium Catalyzed

Hydrazone assists Pd(ii)/(iv) oxidative addition and is the methylene synthon in a palladium-catalyzed, norbornene-mediated regioselective synthesis of fluorenes.

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