Insertion of Allenes into the Pd–C Bond of Ortho-Palladated Primary Arylamines of Biological Relevance: Phenethylamine, Phentermine, (l)-Phenylalanine Methyl Ester, and (l)-Tryptophan Methyl Ester. Synthesis of Tetrahydro-3-benzazepines and Their Salts

2012 ◽  
Vol 31 (23) ◽  
pp. 8333-8347 ◽  
Author(s):  
José-Antonio García-López ◽  
Isabel Saura-Llamas ◽  
John E. McGrady ◽  
Delia Bautista ◽  
José Vicente
Keyword(s):  
Methyl Ester ◽  
Ester Synthesis ◽  
Biological Relevance ◽  
Phenylalanine Methyl Ester ◽  
Tryptophan Methyl Ester

scholarly journals Comparative studies of the specificities of α-chymotrypsin and subtilisin BPN′. Studies with flexible substrates

1972 ◽  
Vol 126 (3) ◽  
pp. 645-657 ◽  
Author(s):  
T. N. Pattabiraman ◽  
W. B. Lawson
Keyword(s):  
Methyl Ester ◽  
Binding Site ◽  
Comparative Studies ◽  
Detrimental Effect ◽  
Flexible Substrates ◽  
Enhancing Effect ◽  
Wide Range ◽  
Phenylalanine Methyl Ester ◽  
Hydrolysis Of ◽  
Tryptophan Methyl Ester

A series of arylalkanoate esters and α-acetamidoarylalkanoate esters were tested as substrates for α-chymotrypsin and subtilisin BPN′. Chymotrypsin hydrolysed N-acetyl-l-phenylalanine methyl ester and methyl 4-phenylbutyrate faster than their respective higher and lower homologues, whereas methyl 2-acetamido-6-phenylhexanoate and methyl 6-phenylhexanoate were better substrates for subtilisin than their lower homologues. N-Acetyl-l-tryptophan methyl ester and its analogue, N-acetyl-3-(1-naphthyl)-alanine methyl ester, were hydrolysed 23 times faster by chymotrypsin than by subtilisin. These results indicate that the binding site of α-chymotrypsin is roughly 1.1nm (11Å) long and curved, whereas that of subtilisin is a longer system and less curved. The stereo-specificity during the hydrolysis of typical substrates by both enzymes was found to vary over a wide range. The enhancing effect of the α-acetamido group in the l-series of substrates and the detrimental effect in the d-series of substrates also varies considerably.

scholarly journals Recognizing Amino Acid Chirality with Surface-Imprinted Polymers Prepared in W/O Emulsions

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Min Jae Shin ◽  
Young Jae Shin ◽  
Seung Won Hwang ◽  
Jae Sup Shin
Keyword(s):  
Methyl Ester ◽  
Crosslinking Agent ◽  
Water Soluble ◽  
Solid Polymer ◽  
Cavity Surface ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Phenylalanine Methyl Ester ◽  
Tryptophan Methyl Ester ◽  
Enantiomeric Selectivity

A molecularly imprinted polymer was prepared by a surface molecular imprinting technique in water-in-oil (W/O) emulsion. In this technique, the solid polymer, which is molecularly imprinted at the internal cavity surface, is prepared by polymerizing W/O emulsions consisting of a water-soluble imprinted molecule, a functional host molecule, an emulsion stabilizer, and a crosslinking agent. Dioleoyl phosphate was used as an emulsion stabilizer, and this compound also acted as a monomer and a host functional group in the imprinted cavity. Divinylbenzene was used as a crosslinker. Tryptophan methyl ester and phenylalanine methyl ester were used as the target template materials. These imprinted polymers exhibited enantiomeric selectivity in absorption experiments, and the maximum separation factor was 1.58. The enantiomeric selectivity with tryptophan methyl ester was higher than that with phenylalanine methyl ester.

Effects of the preparation method on the performance of the Cu/ZnO/Al2O3 catalyst for the manufacture of l-phenylalaninol with high ee selectivity from l-phenylalanine methyl ester

2014 ◽  
Vol 4 (4) ◽  
pp. 1132-1143 ◽  
Author(s):  
Zhangping Shi ◽  
Xiuzhen Xiao ◽  
Dongsen Mao ◽  
Guanzhong Lu
Keyword(s):  
Methyl Ester ◽  
Catalytic Hydrogenation ◽  
Preparation Method ◽  
Phenylalanine Methyl Ester ◽  
Al2o3 Catalyst

Efficient catalytic hydrogenation of l-phenylalanine methyl ester to l-phenylalaninol over the Cu/ZnO/Al2O3 catalyst with ~100% ee selectivity.

scholarly journals 4-fluorobenzylamine and phenylalanine methyl ester conjugates OF 2-nitroimidazole: Evaluation as hypoxic cell radiosensitizers

1992 ◽  
Vol 22 (3) ◽  
pp. 593-596 ◽  
Author(s):  
Pradeep K. Arg ◽  
Sudha Garg ◽  
William G. Degraff ◽  
Michael R. Zalutsky ◽  
James B. Mitchell
Keyword(s):  
Methyl Ester ◽  
Hypoxic Cell ◽  
Phenylalanine Methyl Ester

Optimization of esterification of fatty acid rubber seed oil for methyl ester synthesis in a plug flow reactor

2016 ◽  
Vol 13 (7) ◽  
pp. 720-729 ◽  
Author(s):  
Tho Dinh Son Van ◽  
Nghia Phan Trung ◽  
Vu Nguyen Anh ◽  
Huong Nguyen Lan ◽  
Anh To Kim
Keyword(s):  
Fatty Acid ◽  
Methyl Ester ◽  
Seed Oil ◽  
Flow Reactor ◽  
Plug Flow ◽  
Plug Flow Reactor ◽  
Ester Synthesis ◽  
Rubber Seed Oil ◽  
Rubber Seed
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