Induction of insulin‐like growth factor binding protein expression by ICI 182,780 in a tamoxifen‐resistant human breast cancer cell line

1999 ◽  
Vol 55 (3) ◽  
pp. 231-242 ◽  
Author(s):  
John P. Parisot ◽  
Kerri S. Leeding ◽  
Xiu F. Hu ◽  
Mario DeLuise ◽  
John R. Zalcberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Protein Expression ◽  
Cell Line ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Tamoxifen Resistant

The cytostatic effects of α-interferon may be mediated by transforming growth factor-β

1989 ◽  
Vol 2 (2) ◽  
pp. 131-136 ◽  
Author(s):  
D. J. Kerr ◽  
I. B. Pragnell ◽  
A. Sproul ◽  
S. Cowan ◽  
T. Murray ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Line ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Transforming Growth Factor ◽  
Cancer Cell Line ◽  
Transforming Growth Factor Β ◽  
Human Breast Cancer Cell ◽  
Human Breast

ABSTRACT There is some evidence to suggest that transforming growth factor-β (TGF-β) mediates the cytostatic effects of the anti-oestrogen tamoxifen. In this study we have demonstrated that α-interferon has a significant anti-proliferative effect on the oestrogen receptor-positive human breast cancer cell line ZR-75. There is decreased phenotypic expression of the oestrogen receptors (to about 30% of control values) and increased TGF-β mRNA. Under the growth conditions used here, ZR-75 cells had approximately 5800 TGF-β binding sites per cell, with an apparent dissociation constant of 70 pm, and we have shown that the anti-proliferative effects of α-interferon can be reduced by 60% by co-treating the cells with a TGF-β polyclonal antibody. The cytostatic effects of α-interferon may therefore be mediated by TGF-β in this human breast cancer cell line.

Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line

2001 ◽  
Vol 174 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Tsuyoshi Shimo ◽  
Satoshi Kubota ◽  
Seiji Kondo ◽  
Tohru Nakanishi ◽  
Akira Sasaki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Connective Tissue ◽  
Cell Line ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Tissue Growth ◽  
Human Breast Cancer Cell ◽  
Human Breast
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