Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse

Seven years ago the authors examined 64 consecutive female out-patients with macrocytosis (erythrocyte mean cell volume ⩾ 100 fl). The cause remained undetermined in 23 (35.9%). Their patient histories were evaluated in 1992, and the new highly specific alcohol marker, serum carbohydrate-deficient transferrin, from the frozen sera taken during the initial study was examined. It was elevated in 6 of the 23 women. Furthermore, four of these six had visited the health centre after 1985 and they all had clinical records indicative of alcohol problems. Because early intervention has proved to be effective, information about the risks of alcohol abuse (intervention) should be given to women with suspect alcohol-induced symptoms or signs.

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The Effect of Drinking Intensity and Frequency on Serum Carbohydrate-Deficient Transferrin and gamma-Glutamyl Transferase Levels in Outpatient Alcoholics

Alcoholism Clinical and Experimental Research ◽

10.1097/00000374-199810000-00013 ◽

1998 ◽

Vol 22 (7) ◽

pp. 359

Author(s):

Raymond F. Anton ◽

Robert L. Stout ◽

James S. Roberts ◽

John P. Allen

Keyword(s):

Gamma Glutamyl Transferase ◽

Gamma Glutamyl ◽

Carbohydrate Deficient Transferrin ◽

Glutamyl Transferase

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Gamma-glutamyl Transferase Levels are Associated with the Occurrence of Post-stroke Cognitive Impairment: A Multicenter Cohort Study

10.21203/rs.3.rs-789716/v1 ◽

2021 ◽

Author(s):

Siqi Li ◽

Xiaoling Liao ◽

Yuesong Pan ◽

Xianglong Xiang ◽

Yumei Zhang

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Gamma Glutamyl Transferase ◽

Multicenter Cohort Study ◽

Gamma Glutamyl ◽

Post Stroke ◽

Multicenter Cohort ◽

Glutamyl Transferase ◽

The Impact

Abstract Background: Gamma-glutamyl transferase (GGT) can maintain the physiological concentration of glutathione in cells, and protect them from oxidative stress-induced damage. However, its role in post-stroke cognitive impairment (PSCI) remains unknown. Here, we explored the impact of serum biomarker-GGT on PSCI. Methods: We conducted a prospective, multicenter cohort study. 1, 957 participants who suffered a stroke and measured baseline GGT were enrolled from the Impairment of Cognition and Sleep (ICONS) study of the China National Stroke Registry-3 (CNSR-3). They were categorized into four groups according to the quartiles of baseline GGT levels. Cognitive function was assessed by using the Montreal Cognitive Assessment (MoCA) approach. The multiple logistic regression models were performed to evaluate the relationship between GGT and PSCI at 3 months follow-up.Results: Among 1,957 participants, 671 (34.29%) patients suffered PSCI at 3 months follow-up. The highest GGT level quartile group exhibited a lower risk of PSCI in the fully adjusted model [OR (95% CI): 0.69 (0.50-0.96)], relative to the lowest group. Moreover, incorporation of GGT to the conventional model resulted in a slight improvement in PSCI outcomes after 3 months (NRI: 12.00%; IDI: 0.30%).Conclusions: Our findings demonstrated that serum GGT level was inversely associated with the risk of PSCI, with extremely low levels acting as a risk factor for PSCI.

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