Role of the psychologist on a radical head and neck surgical service team.

AbstractHead and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is characterized by high morbidity and low survival rates with limited therapeutic options outside of regional surgery, conventional cytotoxic chemotherapy, and irradiation. Increasing studies have supported the synergistic role of the tumor microenvironment (TME) in cancer advancement. The immune system, in particular, plays a key role in surveillance against the initiation, development, and progression of HNSCC. The understanding of how neoplastic cells evolve and evade the immune system whether through self-immunogenicity manipulation, or expression of immunosuppressive mediators, provides the foundation for the development of advanced therapies. Furthermore, the crosstalk between cancer cells and the host immune system have a detrimental effect on the TME promoting angiogenesis, proliferation, and metastasis. This review provides a recent insight into the role of the key inflammatory cells infiltrating the TME, with a focus on reviewing immunological principles related to HNSCC, as cancer immunosurveillance and immune escape, including a brief overview of current immunotherapeutic strategies and ongoing clinical trials.

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The potential role of DEK over-expression in the radiation response of head and neck cancer

Radiation Medicine and Protection ◽

10.1016/j.radmp.2021.01.004 ◽

2021 ◽

Author(s):

Hui Xiao ◽

Bismarck Odei ◽

Steven K. Clinton ◽

Darrion L. Mitchell

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Potential Role ◽

Radiation Response ◽

Over Expression

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The effect of plane of nutrition on the carcasses of pigs and lambs when variations in fat content are excluded

Animal Science ◽

10.1017/s0003356100021899 ◽

1964 ◽

Vol 6 (2) ◽

pp. 141-154 ◽

Cited By ~ 75

Author(s):

F. W. H. Elsley ◽

I. McDonald ◽

V. R. Fowler

Keyword(s):

Head And Neck ◽

Fat Content ◽

Fat Deposition ◽

Total Weight ◽

Review Of The Literature ◽

Growth Data ◽

Relative Retardation ◽

Numerical Expression

1. From a review of the literature it has been shown that there are two opposing views regarding the best method of interpreting growth data, which arise from conflicting opinions as to the role of fat deposition in the growth of the animal.2. Data of McMeekan and Palsson and Verges have been re-analysed and their own results are compared with results obtained when the effects of variation in fat content are eliminated.3. No evidence has been found of any effect of plane of nutrition on the total weights of bone and muscle relative to the weight of bone plus muscle together.4. The weight of bone plus muscle in the head and neck was increased relative to the total weight of bone plus muscle during periods of restricted nutrition. Apart from this there was no clear evidence of a relationship between the order of maturity of the joints and their relative retardation of development.5. Huxley's allometry equation was found appropriate for standardising the measurements, and the exponent was taken as a numerical expression of the relative maturity of each tissue or part.

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