AbstractObjectiveWe aim to provide the first evidence of mental distress and its associated predictors among adults in the ongoing COVID-19 crisis in Brazil.MethodsWe conducted a primary survey of 638 adults in Brazil on March 25–28, 2020, about one month (32 days) after the first COVID-19 case in South America was confirmed in São Paulo.ResultsIn Brazil, 52% (332) of the sampled adults experienced mild or moderate distress, and 18.8% (120) suffered severe distress. Adults who were female, younger, more educated, and exercised less reported higher levels of distress. Each individual’s distance from the Brazilian epicenter of São Paulo interacted with age and workplace attendance to predict the level of distress. The “typhoon eye effect” was stronger for people who were older or attended their workplace less. The most vulnerable adults were those who were far from the epicenter and did not go to their workplace in the week before the survey.ConclusionIdentifying the predictors of distress enables mental health services to better target finding and helping the more mentally vulnerable adults during the ongoing COVID-19 crisis.