Perception of Abuse Severity Predicts PTSD Risk and HPA Function

2009 ◽  
Author(s):  
Justine Phifer ◽  
Lauren Sands ◽  
Bekh Bradley ◽  
Kerry Ressler ◽  
Tamara Weiss
1992 ◽  
Vol 1 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Ada C. Mezzich ◽  
Ralph E. Tarter ◽  
Ya-Chen Hsieh ◽  
Amy Fuhrman

2019 ◽  
Vol 65 (3) ◽  
pp. 378-383
Author(s):  
Elizabeth M. Saewyc ◽  
Janna R. Gewirtz O'Brien ◽  
Kathleen K. Miller ◽  
Laurel D. Edinburgh

1992 ◽  
Vol 160 (S15) ◽  
pp. 7-17 ◽  
Author(s):  
Stuart Checkley

It is now generally accepted that stressful life events and chronic difficulties can trigger the onset of depression in predisposed individuals. However, although much is known of the neurobiology of stress, few attempts have been made to provide a biological explanation for the mechanisms whereby life events might trigger depression. Enough is now known of the central control of hypothalamic pituitary adrenal (HPA) function and its response to stress to permit an examination of its role in the neurobiology of the triggering of depression by stress. This evidence is reviewed, and the proposal explored that stress triggers depression by a genomic action of corticosteroids.


2019 ◽  
Vol 34 (6) ◽  
pp. 1079-1079
Author(s):  
A Olsen ◽  
M Marr ◽  
D De Boer ◽  
E Jackson ◽  
K Mackiewicz Seghete

Abstract Objective Decision-making requires weighing potential gains and losses. Adolescents who have experienced maltreatment may be more sensitive to potential gains or losses than other adolescents. The aim of these analyses was to examine trajectories of decision-making over time in adolescents based on maltreatment history and severity. Method The study included 69 adolescents 13 to 17 years old (M = 14.9). Maltreatment history and severity were assessed using the Childhood Trauma Questionnaire. Adolescents also completed a modified Iowa Gambling Task (mIGT). Outcomes of interest were the percentage of advantageous responses and net score (measure of overall performance integrating advantageous and disadvantageous plays) for each of three blocks. Results The trajectory of performance across blocks was defined using a conditional linear growth curve model with factor loadings fixed at block 1, block 2, and block 3. Greater maltreatment severity was associated with less increase in net score over time (M = -4.453, p < .001). In contrast, abuse severity (M = 6.675, p = .002) and the presence of neglect (M = 13.058, p = .002) were associated with sharper increases in net score. A regression revealed maltreatment severity, presence of abuse, presence of neglect, and abuse severity significantly predicted the percentage of advantageous plays only during the second block of the mIGT (R2 = .180, p = .030). Conclusions This study provides evidence that maltreatment history and severity are associated with the trajectory of decision-making over time. It also provides support for the importance of examining performance trajectory and heterogeneity in maltreatment regarding cognitive processing.


Pituitary ◽  
2019 ◽  
Vol 22 (2) ◽  
pp. 170-178 ◽  
Author(s):  
Yosra Moria ◽  
Rouba Kortbawi ◽  
Nadine EL-Asmar ◽  
Baha M. Arafah

2011 ◽  
Vol 23 (2) ◽  
pp. 275 ◽  
Author(s):  
Jacqueline M. Wallace ◽  
John S. Milne ◽  
Lucy R. Green ◽  
Raymond P. Aitken

The relationship between impaired fetal nutrient supply and postnatal hypothalamic–pituitary–adrenal (HPA) function was examined in ovine models of prenatal growth restriction (GR) caused by small placental size (SP) or by maternal undernutrition (UN). Adrenocorticotrophin (ACTH) and cortisol responses following corticotrophin-releasing hormone (CRH) plus arginine vasopressin (AVP) challenge were examined at 9, 18 and 24 months in growth-restricted (GR-SP) and normal birthweight (control) females (Experiment 1), and at 6 months in growth-restricted (GR-SP, GR-UN) and normal weight males and females (Experiment 2). In Experiment 1, GR-SP offspring were born early, were 40% lighter at birth and had higher fractional weight gains to weaning than control offspring. Baseline ACTH and cortisol were independent of GR and cortisol decreased with age. GR did not affect the HPA response to CRH + AVP challenge at any stage, but ACTH increased with age. In Experiment 2, birthweight was greater in control offspring than in GR-UN offspring, which had a higher birthweight again compared with GR-SP offspring. Only the latter group was born early and exhibited rapid catch-up growth to weaning. Neither nutritional route to GR altered HPA function at 6 months. Males grew faster than females and HPA responses after stimulation were lower in males. Together, the results of these studies demonstrate that postnatal HPA function in sheep is influenced by age and sex, but not by GR.


2018 ◽  
pp. 088626051880103 ◽  
Author(s):  
Abigail W. Batchelder ◽  
Steven A. Safren ◽  
Jessica N. Coleman ◽  
Michael S. Boroughs ◽  
Aron Thiim ◽  
...  

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