The effects of cannabidiol (CBD) on Δ⁹-tetrahydrocannabinol (THC) self-administration in male and female Long-Evans rats.

2017 ◽  
Vol 25 (4) ◽  
pp. 242-248 ◽  
Author(s):  
Alison G. P. Wakeford ◽  
Bradley B. Wetzell ◽  
Rebecca L. Pomfrey ◽  
Matthew M. Clasen ◽  
William W. Taylor ◽  
...  
Keyword(s):  
Self Administration ◽  
Male And Female ◽  
Long Evans

scholarly journals Increased alcohol self-administration following exposure to the predator odor TMT in high stress-reactive female rats

2020 ◽  
Author(s):  
Laura C. Ornelas ◽  
Ryan E. Tyler ◽  
Preethi Irukulapati ◽  
Sudheesha Paladugu ◽  
Joyce Besheer
Keyword(s):  
Individual Differences ◽  
Alcohol Drinking ◽  
Stress Reactivity ◽  
High Stress ◽  
Predator Odor ◽  
Female Rats ◽  
List Type ◽  
Self Administration ◽  
Male And Female ◽  
Long Evans

AbstractPost-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are highly comorbid. Additionally, individual differences in response to stress suggest resilient and susceptible populations. The current study exposed male and female Long Evans rats to the synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) to examine individual differences in stress-reactive behaviors (digging and immobility) and whether these differences could predict lasting consequences of TMT and increases in alcohol drinking. Male and female Long Evans rats were trained on operant alcohol self-administration. After 9 sessions, rats underwent exposure to TMT or water (Control) in a distinct context. 6 days after TMT exposure, rats underwent re-exposure to the TMT-paired context (without TMT), and a series of behavioral assessments (acoustic startle, zero maze, light/dark box), after which rats resumed alcohol self-administration. Rats were divided into two TMT-subgroups using a ratio of digging and immobility behavior during TMT exposure: TMT-subgroup 1 (low digging/immobility ratio) and TMT-subgroup 2 (high digging/immobility ratio). Digging/immobility ratio scores predicted elevated corticosterone levels during TMT exposure and reactivity during context re-exposure in males and females (TMT-subgroup 2), as well as elevated corticosterone levels after context re-exposure and hyperarousal behavior in females (TMT-subgroup 1). Furthermore, TMT stress reactivity predicted increases in alcohol self-administration, specifically in females. These data show that stress-reactivity can predict lasting behavioral changes which may lead to a better understanding of increases in alcohol drinking following stress in females and that individual differences in stress-reactive behaviors using TMT may be helpful to understand resilience/susceptibility to the lasting consequences of stress.HighlightsExposure to the predator odor TMT produces distinct behavioral phenotypes in male and female ratsMale and female high stress reactive rats show enhanced reactivity to the TMT-paired contextStress-reactivity during TMT predicts increases in alcohol self-administration, in femalesStress-reactivity may help to understand resilience/susceptibility and impact on alcohol drinking

scholarly journals Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking

2019 ◽  
Vol 22 (11) ◽  
pp. 710-723 ◽  
Author(s):  
Atul P Daiwile ◽  
Subramaniam Jayanthi ◽  
Bruce Ladenheim ◽  
Michael T McCoy ◽  
Christie Brannock ◽  
...  
Keyword(s):  
Sex Differences ◽  
Nucleus Accumbens ◽  
Fixed Ratio ◽  
Female Rats ◽  
Male Rats ◽  
Mrna Levels ◽  
Self Administration ◽  
Male And Female ◽  
Orexin Receptors ◽  
Male And Female Rats

Abstract Background Methamphetamine (METH) use disorder is prevalent worldwide. There are reports of sex differences in quantities of drug used and relapses to drug use among individuals with METH use disorder. However, the molecular neurobiology of these potential sex differences remains unknown. Methods We trained rats to self-administer METH (0. 1 mg/kg/infusion, i.v.) on an fixed-ratio-1 schedule for 20 days using two 3-hour daily METH sessions separated by 30-minute breaks. At the end of self-administration training, rats underwent tests of cue-induced METH seeking on withdrawal days 3 and 30. Twenty-four hours later, nucleus accumbens was dissected and then used to measure neuropeptide mRNA levels. Results Behavioral results show that male rats increased the number of METH infusions earlier during self-administration training and took more METH than females. Both male and female rats could be further divided into 2 phenotypes labeled high and low takers based on the degree of escalation that they exhibited during the course of the METH self-administration experiment. Both males and females exhibited incubation of METH seeking after 30 days of forced withdrawal. Females had higher basal mRNA levels of dynorphin and hypocretin/orexin receptors than males, whereas males expressed higher vasopressin mRNA levels than females under saline and METH conditions. Unexpectedly, only males showed increased expression of nucleus accumbens dynorphin after METH self-administration. Moreover, there were significant correlations between nucleus accumbens Hcrtr1, Hcrtr2, Crhr2, and Avpr1b mRNA levels and cue-induced METH seeking only in female rats. Conclusion Our results identify some behavioral and molecular differences between male and female rats that had self-administered METH. Sexual dimorphism in responses to METH exposure should be considered when developing potential therapeutic agents against METH use disorder.

Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats

2006 ◽  
Vol 191 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Wendy J. Lynch ◽  
Drew D. Kiraly ◽  
Barbara J. Caldarone ◽  
Marina R. Picciotto ◽  
Jane R. Taylor
Keyword(s):  
Female Rats ◽  
Self Administration ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Self-administration of methamphetamine aerosol by male and female baboons

2018 ◽  
Vol 168 ◽  
pp. 17-24 ◽  
Author(s):  
Richard W. Foltin
Keyword(s):  
Self Administration ◽  
Male And Female

scholarly journals Effects of nicotine exposure on oral methamphetamine self-administration, extinction, and drug-primed reinstatement in adolescent male and female rats

2020 ◽  
Vol 209 ◽  
pp. 107927 ◽  
Author(s):  
Zachary R. Harmony ◽  
Erin M. Alderson ◽  
Israel Garcia-Carachure ◽  
Laurence D. Bituin ◽  
Cynthia A. Crawford
Keyword(s):  
Female Rats ◽  
Adolescent Male ◽  
Nicotine Exposure ◽  
Self Administration ◽  
Male And Female ◽  
Male And Female Rats

Characterization of spatial performance in male and female Long-Evans rats by means of the Morris water task and the ziggurat task

2010 ◽  
Vol 81 (1) ◽  
pp. 164-172 ◽  
Author(s):  
Jamshid Faraji ◽  
Gerlinde A. Metz ◽  
Robert J. Sutherland
Keyword(s):  
Male And Female ◽  
Morris Water Task ◽  
Spatial Performance ◽  
Long Evans

96-hour methamphetamine self-administration in male and female rats: Effects on brain reward pathways

2015 ◽  
Vol 146 ◽  
pp. e251-e252
Author(s):  
Elyse M. Cornett ◽  
Nicholas E. Goeders
Keyword(s):  
Female Rats ◽  
Self Administration ◽  
Male And Female ◽  
Male And Female Rats ◽  
Brain Reward ◽  
Reward Pathways

scholarly journals Nicotine self-administration and reinstatement of nicotine-seeking in male and female rats

2012 ◽  
Vol 121 (3) ◽  
pp. 240-246 ◽  
Author(s):  
Matthew W. Feltenstein ◽  
Shannon M. Ghee ◽  
Ronald E. See
Keyword(s):  
Female Rats ◽  
Self Administration ◽  
Male And Female ◽  
Male And Female Rats
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