Chemotherapy of Theileria parva infection

Theileria parva causes widespread morbidity and mortality in cattle in endemic regions. An outbreak of theileriosis occurred on a farm near Ladysmith in KwaZulu-Natal, South Africa, which is not a declared Corridor disease-infected area. A survey of Red Brangus cattle from all age groups and areas of the farm was performed. Transmission of the parasite from infected animals on the farm to susceptible animals by tick transmission and tick-stabilate injection, was attempted. The survey indicated high numbers of animals with antibody titres to T. parva but only 6 infected animals, based on real-time PCR and RLB analysis. The transmission experiments failed to transmit the parasite. The study shows the difficulty in elucidating a source of infection and determining the dynamics of new infections in a herd where multiple possible sources are present and treatment with tetracyclines has taken place.

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Morbidity and Mortality Rates in East Coast Fever ( Theileria Parva Infection) and their Application to Drug Screening Procedures

British Veterinary Journal ◽

10.1016/s0007-1935(17)43303-3 ◽

1961 ◽

Vol 117 (12) ◽

pp. 529-531 ◽

Cited By ~ 128

Author(s):

D.W. Brocklesby ◽

S.F. Barnett ◽

G.R. Scott

Keyword(s):

Drug Screening ◽

East Coast ◽

Mortality Rates ◽

East Coast Fever ◽

Morbidity And Mortality ◽

Theileria Parva ◽

Screening Procedures ◽

Theileria Parva Infection

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Clinical efficacy and plasma concentrations of two formulations of buparvaquone in cattle infected with East Coast fever (Theileria parva infection)

Research in Veterinary Science ◽

10.1016/j.rvsc.2005.09.012 ◽

2006 ◽

Vol 81 (1) ◽

pp. 119-126 ◽

Cited By ~ 7

Author(s):

G.R. Muraguri ◽

P.N. Ngumi ◽

D. Wesonga ◽

S.G. Ndungu ◽

J.M. Wanjohi ◽

...

Keyword(s):

Clinical Efficacy ◽

East Coast ◽

Plasma Concentrations ◽

East Coast Fever ◽

Theileria Parva ◽

Theileria Parva Infection

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Duration of immunity to East Coast fever (Theileria parva infection of cattle)

Parasitology ◽

10.1017/s0031182000045571 ◽

1972 ◽

Vol 64 (3) ◽

pp. 511-515 ◽

Cited By ~ 44

Author(s):

M. J. Burridge ◽

S. P. Morzaria ◽

M. P. Cunningham ◽

C. G. D. Brown

Keyword(s):

East Coast ◽

Tick Control ◽

East Coast Fever ◽

Initial Reaction ◽

Theileria Parva ◽

Lethal Challenge ◽

Gradual Loss ◽

Cattle Diseases ◽

Immunological Research ◽

Theileria Parva Infection

Forty-five cattle, which had recovered from EOF and been kept free from reexposure to infection for periods of 1–43 months, were given a single uniform lethal challenge using a stabilate prepared from triturated infected ticks. All withstood the challenge which killed the five controls. There was an increase in the incidence of mild febrile reactions with time since last exposure to T. parva, indicating a gradual loss of immunity in the absence of reinfection. The duration of the immunity was not related to the severity of the initial reaction.We are indebted to our colleagues on the Immunological Research on Tickborne Cattle Diseases and Tick Control Project, with whom we designed and carried out the experiment.

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